DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpgamma and Trpc1

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_006511116.1	Gene:	Trpc1 / 22063	MGIID:	109528	Length:	802	Species:	Mus musculus

Alignment Length:	843	Identity:	333/843 - (39%)
Similarity:	490/843 - (58%)	Gaps:	124/843 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SESSGSGHIAVQIEPARRVKRHSIHGMMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRRM 100
            |.||.|.:..:.::..|.||         |||           ||.||.||||.::||....:::
Mouse    38 SPSSSSPNEVMALKDVREVK---------EEN-----------TLNEKLFLLACDKGDYYMVKKI 82

  Fly   101 LQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINYNVDTKDALLHSISEEFVEAVEVLL 165
            |::....: :|:||||.|||.|:.:.|:||:|::::||::|...:.||||.:|..|.|.||::||
Mouse    83 LEENSSGD-LNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILL 146

  Fly   166 DHENVTFHSEGNHSWESASEDT-------------STFTPDITPLILAAHRDNYEIIKILLDRGA 217
                       ||..:.:|..|             || |.|:.|:||||||:||||:.:||.:..
Mouse   147 -----------NHRPKRSSRPTIVKLMERIQNPEYST-TMDVAPVILAAHRNNYEILTMLLKQDV 199

  Fly   218 VLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLS 282
            .||.||.|.|.|..|....::||||||       |.||||:||.|:.:||||.|||||.:|:.||
Mouse   200 SLPKPHAVGCECTLCSAKNKKDSLRHS-------RCLASPALIMLTEEDPILRAFELSADLKELS 257

  Fly   283 FLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTG-PVYEHG---ERMHLNRLKLA 343
            .:|.||:|:|:||.:||:.||..||...|.|.|||::|||..:. |:.:.|   |||:|:|||||
Mouse   258 LVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLA 322

  Fly   344 IKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQ 408
            ||..||:||:.||.||.|.::|:..:.|:|||....:.:.::.:||.:|:.||.|::||.|..|:
Mouse   323 IKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGR 387

  Fly   409 TMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEW 473
            .:..||:|||.|.|||||||.||.|.|           ...:....|||       |.....|::
Mouse   388 IIHTPFMKFIIHGASYFTFLLLLNLYS-----------LVYNEDKKNTM-------GPALERIDY 434

  Fly   474 LILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQKEMIYNSHA 538
            |::.|:.|:|||::|:||..||:::|.:..|.:.||.||||:||.||:||:         :|...
Mouse   435 LLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVA---------HNKFH 490

  Fly   539 TDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFFLYVL 603
            ....|:.|||:.|.|::||||:.||:.|.|:|.::::.:..|||||:|:.:|:.|..||..:::|
Mouse   491 DFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLL 555

  Fly   604 VLFAFGSGLNQLLWY---YADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQTLF 665
            |||:|..||.||  |   |...|:|.|      ..:.....:||        .|.:...|...||
Mouse   556 VLFSFTIGLTQL--YDKGYTSKEQKDC------VGIFCEQQSND--------TFHSFIGTCFALF 604

  Fly   666 WAVFGLIDLDSF--------ELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISE 722
            |.:|.|..:..|        ||..      |.|.::.|||:|:.::||..||:||::.|:|||:.
Mouse   605 WYIFSLAHVAIFVTRFSYGEELQS------FVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIAN 663

  Fly   723 RADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSS---AARREHLKT 784
            ..|.||||||:|||:|||::..|.||||||||:||:|.|.|..:.:..||.:|   ..|:..||.
Mouse   664 HEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKE 728

  Fly   785 IRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAES-QGVTEDDVNEIKQDISAFRCELVEIL 846
            .|...|:   ||..||::|..||.||:|..::|.:| ...|.:::||::||:|.||.|:.::|
Mouse   729 WRNLKQK---RDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	321/795 (40%)
		ANK	113..>217	CDD:238125	47/116 (41%)
		ANK repeat	118..147	CDD:293786	11/28 (39%)
		ANK repeat	175..217	CDD:293786	21/54 (39%)
		TRP_2	227..286	CDD:285535	29/58 (50%)
		RRT14	<778..892	CDD:293680	27/70 (39%)
Trpc1	XP_006511116.1	trp	64..783	CDD:273311	319/790 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	O	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750