Protein Alignment Trpgamma and trp-2

DIOPT Version :10

• Sequence 1: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_001022703.1
• Gene: trp-2 / 192056
• WormBaseID: WBGene00006615
• Length: 886
• Species: Caenorhabditis elegans
• Alignment Length: 874
• Identity: 403/874 - (46%)
• Similarity: 563/874 - (64%)
• Gaps: 64/874 - (7%)

  Fly    62 MMEEENTIRPH---QEIRQLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTAL 123
            |:|:::.:..:   .|.....|.||:|||:.||||:...|::| ....||..|:||:|||||.||
 Worm    11 MIEDDDDVSNNVTWTESDNSRLREKQFLLSCERGDIGSVRKLL-AGISTETFNINCLDPLGRNAL 74

  Fly   124 LMAIDNENLEMVELLINYNVDTKDALLHSISEEFVEAVEVLLDH-ENV-TFHSEGNHSWESASED 186
            |:||:|||:||:|||:::|::|.||:|::|.||.|||||::::| |.: .|.||     ....|.
 Worm    75 LIAIENENIEMIELLLDHNIETGDAILYAIGEENVEAVEIIVEHLEKMDKFDSE-----RQGVEI 134

  Fly   187 T--STFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRIN 249
            |  |.|||||||::||||:||||.||:.||:...:|.||||||.|.||..:|:|||||.||||||
 Worm   135 TEHSAFTPDITPIVLAAHKDNYECIKLFLDKKGTVPHPHDVRCSCPECYVAREEDSLRLSRSRIN 199

  Fly   250 AYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSH 314
            |||||.|||||.||::||||.||||||||:||||:|:||:.:|:||.::||.|...:||..|.|.
 Worm   200 AYRALTSPSLICLSARDPILYAFELSWELKRLSFIENEFRTDYEELSQKCQKFCVHMLDQVRGSK 264

  Fly   315 ELEILLN------HDPTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFR 373
            |||::||      ||.|...|.:.|:  |.||||||:|.||:||||.|.||||..|||||:...|
 Worm   265 ELEVVLNHTTNAWHDVTSANYGNPEK--LARLKLAIQLSQKRFVAHPNCQQLLLDIWYEGVESVR 327

  Fly   374 RKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRI 438
            ..|...:.:..|...:.||:|||.|:|||:||:||..:||||||:.||.||..||.||::||||:
 Worm   328 CTNFIYKLIFYILGMLSFPLFSLVYLLAPHSSMGQFAKKPFIKFLSHSGSYIFFLILLIMASQRM 392

  Fly   439 ETFIGGWFFADSSGMLNTMEELPTK--RGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLND 501
            ...         ..:|.| :::..|  ||..||.||..|..||.||||.|:||||:.||..|..:
 Worm   393 NVI---------DNILRT-DDVDRKETRGPPPTIIECAIFLWVLGLIWVEIKQLWECGLYNYCRN 447

  Fly   502 MWNVIDFVTNSLYVATVALRVVSFFQVQKEMI-YNS-H-ATDLPRERWDAWDPMLISEGLFSAAN 563
            :||::||:|||||:.|.|||||::.||::|.: .|| | |..|||..||||||.|:||..|:.||
 Worm   448 LWNILDFITNSLYLCTTALRVVAYVQVEQEALRANSVHIARHLPRRDWDAWDPTLLSECFFATAN 512

  Fly   564 IFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCP 628
            ||||||||:||:|:||||||::||.|||:||:|||.:|.||||||..||||||||||.:.:..|.
 Worm   513 IFSSLKLVHIFTVSPHLGPLKISLGRMVIDIVKFFMVYALVLFAFACGLNQLLWYYASMRQNECN 577

  Fly   629 --EVSPMSALLNMNGTNDPNAC-IVWRRFSNLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWG 690
              |.......|:....:...:| ..::..|:::.|.:|||||:|||:||..|.|......:.:.|
 Worm   578 LYEQYKNEKSLSYKYEHLKESCDDKYKSCSSIYHTAETLFWALFGLVDLTHFRLKEDHFLSEWTG 642

  Fly   691 MLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPT 755
            ..:||:|...:|:||||:|||||::|||.||::||:|||||||:|::.||::..|.||||||:|:
 Worm   643 KTIFGSYCCCSIIVLLNMLIAMMSNSYQYISDQADIEWKFARSRLFLEYFDDTATLPPPFNIVPS 707

  Fly   756 PKSIWYAIKWMRRVFCSGSSAARREHLKTIRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAES 820
            ||||:|.:.::.:..|:.:...:....|::|.:::..:.|....:|:..|..:...:..|..:.:
 Worm   708 PKSIYYCLHYLTKKLCNCTKLQQPSKQKSMRVESKNLAIRQRPRKQLPENCAKNRYSGAQFHSRN 772

  Fly   821 QGVTEDDVNEIKQDISAFRCELVEILKNSGMDTNVTAGQGGGGGKKNRQKERRLMKGFNIAPPGS 885
            :..|......:|.  ||.      :||...:.....|||                :..:|:...|
 Worm   773 KKKTAMAERRLKN--SAL------LLKEFPVPQMFKAGQ----------------RNMSISSIQS 813

  Fly   886 TGSLAPVAEFSTSLDNYDNQHEILSSTLS 914
            .|.|.|....|:|..::.|. ::.:|.||
 Worm   814 NGRLKPSFMPSSSKLSWSNL-KVKASRLS 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	384/781 (49%)
		ANK repeat	118..147	CDD:293786	18/28 (64%)
		ANK repeat	175..217	CDD:293786	23/43 (53%)
		TRP_CaM_bind1	865..>891	CDD:467881	4/25 (16%)
trp-2	NP_001022703.1	TRPV	34..757	CDD:454755	377/740 (51%)
		ANK repeat	69..96	CDD:293786	17/26 (65%)