DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Trpgamma and trp-4

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_493429.2	Gene:	trp-4 / 190574	WormBaseID:	WBGene00006616	Length:	1924	Species:	Caenorhabditis elegans

Alignment Length:	792	Identity:	183/792 - (23%)
Similarity:	326/792 - (41%)	Gaps:	170/792 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLI----NYNVDTKD 147
            ||.::|.:|....:|.::...::..    |..|||.|.:|..|.:.|||.|||    |.||..::
Worm  1245 LAAQQGHIAVVGMLLSRSTQQQHAK----DWRGRTPLHLAAQNGHYEMVSLLIAQGSNINVMDQN 1305

  Fly   148 AL--LHSISEE-FVEAVEVLLDHENVTFHSEGNHSWESASEDTSTFTPDITPLILAAHRDNYEII 209
            ..  ||..:.. .:..|::.:|               |:::..:.......||..||..::.|.:
Worm  1306 GWTGLHFATRAGHLSVVKLFID---------------SSADPLAETKEGKVPLCFAAAHNHIECL 1355

  Fly   210 KILLDRGAVLPMPHDVRCGCDE---------CVQSRQEDSLRHSRSRINAYRALASPSLIALSSK 265
            :.||.:      .||.....::         |.::...:.|:.                ..|.|.
Worm  1356 RFLLKQ------KHDTHQLMEDRKFIFDLMVCGKTNDNEPLQE----------------FILQSP 1398

  Fly   266 DPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLN-HDPTG-PV 328
            .||.||.:||...|.:|..|.|...:...:....::.|..||..|.|.:...:||. .|..| |:
Worm  1399 APIETAVKLSALYRDMSEKEKERAKDLLNVAVFSENMAVELLGITATEYNAALLLKAKDNRGRPL 1463

  Fly   329 YEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPI 393
                       |.:.|:..||:.|::::||:.|..:|...:.....|               |..
Worm  1464 -----------LDVLIENEQKEVVSYASVQRYLTEVWTARVDWSFGK---------------FVA 1502

  Fly   394 FSLAYILAP----YSSI---GQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSS 451
            |||..::.|    |.|:   .:..|.|.|||:||..|:..|..||.:.
Worm  1503 FSLFVLICPPAWFYFSLPLDSRIGRAPIIKFVCHIVSHVYFTILLTIV----------------- 1550

  Fly   452 GMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVA 516
             :||...::.......|..:|||:|.|:||.:   |.:|..||....|    .::..:...|...
Worm  1551 -VLNITHKMYEVTSVVPNPVEWLLLLWLSGNL---VSELSTVGGGSGL----GIVKVLILVLSAM 1607

  Fly   517 TVALRVVSFFQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLG 581
            .:|:.|::|.   ...::.:| .|...:...|...:.:...||:.|.:|:.::.:...:|:...|
Worm  1608 AIAVHVLAFL---LPAVFLTH-LDNDEKLHFARTMLYLKNQLFAFALLFAFVEYLDFLTVHHLFG 1668

  Fly   582 PLQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPN 646
            |..:.:..::.|:.:  ||.:|:||..|..|:....:.        |...|:         ::.:
Worm  1669 PWAIIIRDLMYDLAR--FLVILMLFVAGFTLHVTSIFQ--------PAYQPV---------DEDS 1714

  Fly   647 ACIVWRRFSNLFETTQTLFWAVFGLIDLDSF-ELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLI 710
            |.::  |.::..:|.:.||:::|||::.||. .|..:..|.:....|:||.|.::.::||:||||
Worm  1715 AELM--RLASPSQTLEMLFFSLFGLVEPDSMPPLHLVPDFAKIILKLLFGIYMMVTLIVLINLLI 1777

  Fly   711 AMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFC---- 771
            |||:.:||.|..::|.||||.|:.| |....:....|.|.|:: |...|...:.|..|:.|
Worm  1778 AMMSDTYQRIQAQSDKEWKFGRAIL-IRQMNKKSATPSPINML-TKLIIVLRVAWRNRLRCMTRK 1840

  Fly   772 ---------------SGSSAARREHLKTIRRKAQQ--ASDRDFKYQQIM--RNLVRRYVTVEQRK 817
                           .|.....|:......|:.||  .:..|:..:.::  |.:|..|.....:.
Worm  1841 AQDDLRFEENIDAFSMGGGQQGRQSPTNEGREGQQELGNSADWNIETVIDWRKIVSMYYQANGKL 1905

  Fly   818 AESQGVTEDDVN 829
            .:  |.|::||:
Worm  1906 TD--GRTKEDVD 1915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	183/792 (23%)
		ANK	113..>217	CDD:238125	28/110 (25%)
		ANK repeat	118..147	CDD:293786	15/32 (47%)
		ANK repeat	175..217	CDD:293786	8/41 (20%)
		TRP_2	227..286	CDD:285535	12/67 (18%)
		RRT14	<778..892	CDD:293680	12/56 (21%)
trp-4	NP_493429.2	ANK repeat	804..842	CDD:293786
		ANK repeat	849..884	CDD:293786
		ANK repeat	886..917	CDD:293786
		ANK repeat	919..950	CDD:293786
		ANK repeat	952..982	CDD:293786
		ANK repeat	986..1017	CDD:293786
		PHA03095	1006..>1336	CDD:222980	26/109 (24%)
		ANK repeat	1092..1123	CDD:293786
		ANK repeat	1204..1236	CDD:293786
		trp	1209..1879	CDD:273311	175/752 (23%)
		ANK repeat	1238..1270	CDD:293786	5/28 (18%)
		ANK repeat	1272..1303	CDD:293786	15/30 (50%)
		ANK repeat	1305..1336	CDD:293786	5/45 (11%)
		ANK repeat	1338..1366	CDD:293786	9/33 (27%)
		ANKYR	280..515	CDD:223738
		ANK repeat	352..383	CDD:293786
		ANK repeat	385..418	CDD:293786
		ANK repeat	424..454	CDD:293786
		PHA03095	430..>756	CDD:222980
		ANK repeat	456..489	CDD:293786
		ANK repeat	491..523	CDD:293786
		ANK repeat	526..556	CDD:293786
		ANK repeat	558..590	CDD:293786
		ANK repeat	592..623	CDD:293786
		ANK repeat	625..656	CDD:293786
		ANK repeat	658..688	CDD:293786
		ANK repeat	692..726	CDD:293786
		PHA02876	<712..>1040	CDD:165207
		ANK repeat	728..753	CDD:293786
		ANK repeat	761..802	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3609
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810