Protein Alignment Trpgamma and trp-1

DIOPT Version :10

• Sequence 1: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: NP_001367402.1
• Gene: trp-1 / 176202
• WormBaseID: WBGene00006614
• Length: 1031
• Species: Caenorhabditis elegans
• Alignment Length: 1159
• Identity: 373/1159 - (32%)
• Similarity: 563/1159 - (48%)
• Gaps: 275/1159 - (23%)

  Fly    39 SGSGHIAVQIEPARRVKRH----------SIHGMMEEENTIRPHQEIRQLTLEEKKFLLAVERGD 93
            |.:|....:..|:.|.:|:          ::|  :...:.|.|         ||::||.|.|
 Worm    12 SAAGRRFSRCAPSPRPRRNYALANIPPPAAVH--IRTNDMISP---------EERRFLEAAE--- 62

  Fly    94 MAGTRRMLQKAQDTE---YINVNCVDPLGRTALLMAIDNENLEMVELLINY-NVDTKDALLHSIS 154
             .|.:..||:..|.:   .:||||:|.:|||||.:|:||||:|:||||:.. ::...:|||.:|.
 Worm    63 -LGNKPTLQECLDYDGDRRLNVNCLDSMGRTALEIAVDNENMEVVELLLQQPDIRIGNALLCAIR 126

  Fly   155 EEFVEAVEVLLDHENVTFHSEGNHSWESA---SEDTST-FTPDITPLILAAHRDNYEIIKILLDR 215
            |.....||||::|.|:|....|: .|..|   ||..|. ::.||:|:||||..:.:||:::|:.:
 Worm   127 EGVYRLVEVLVNHPNITREMLGD-GWSQALDPSEAASAEYSSDISPVILAAQLNQFEILQMLIRK 190

  Fly   216 GAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRR 280
            .|.:..||...|.|:.|.:.|..|||::|..|||.:||||||:.::|:|.||||:||:|||:|:|
 Worm   191 DASIEKPHRHSCICETCDRERLNDSLQYSLKRINTFRALASPAWMSLTSPDPILSAFKLSWDLQR 255

  Fly   281 LSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTGPVYEH-----GERMHLNRL 340
            |:|.|||||..|.:|.:||:.::..||...|:|.|:..:||.|  |.|.:.     ..::.|:||
 Worm   256 LAFEEHEFKETYLQLSEQCKQYSCDLLSQCRSSEEVIAILNKD--GNVNDDNIDVWASKLSLSRL 318

  Fly   341 KLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRK-----NMALQAVDIIRIGIMFPIFSLAYIL 400
            |||||..||.||:|.:.||||.||||||:| :|::     |..|.|.    :..::|||.|.|||
 Worm   319 KLAIKYEQKAFVSHPHCQQLLTSIWYEGIP-YRQRSGTWANFFLYAF----LLFLWPIFCLMYIL 378

  Fly   401 APYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEELPTKRG 465
            .|.|.:|:.:|.||:||..:|.|:.|||.||..|:.....:..|    :..||....:     ||
 Worm   379 MPKSRLGRLVRSPFMKFFYYSVSFATFLGLLTWATFEDYRYEKG----ERGGMTRASD-----RG 434

  Fly   466 AKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFF-QVQ 529
            ...|::|.|:..||.|::|||:||||:.|.:.|:...||.:||:...||:.|:::|:.::: ...
 Worm   435 PPATWVESLVFTWVIGMLWSEIKQLWEEGFKRYMRQWWNWLDFLMICLYLCTISIRLSAYYIFTY 499

  Fly   530 KEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDI 594
            :|..|....    |..|.:.:|||::|.||:..|:||..:::|:|..||:|||||:||..|::|:
 Worm   500 REDPYRYTV----RTYWTSEEPMLVAEALFAVGNVFSFARIIYLFQTNPYLGPLQISLGCMLVDV 560

  Fly   595 MKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPN--ACI---VWRRF 654
            .||.|::||::.:|..||.||.|||                        |||  .|:   ..:..
 Worm   561 AKFCFIFVLIISSFSIGLAQLYWYY------------------------DPNTDVCLPGATCKHS 601

  Fly   655 SNLF----ETTQTLFWAVFGLI---DLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAM 712
            ||:|    ::..||.|::|.:.   |.|..|...|   |::.|..||..|...:|:||||:||||
 Worm   602 SNVFSSIADSYLTLLWSLFSITKPEDTDVVENHKI---TQWVGQGMFIMYHCTSIIVLLNMLIAM 663

  Fly   713 MNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWY-------AIKWMRRVF 770
            |:||:|:|::.||:||||.|:|||:::|:||.:.|||||||.||||:.|       .::|:...:
 Worm   664 MSHSFQIINDHADLEWKFHRTKLWMAHFDEGSSLPPPFNIIVTPKSLIYVMNCLFNTVRWLLGKY 728

  Fly   771 CSGSSAARREHLKTIRR-----------KAQQASDRDFK---YQQIMRNLVRRYVTVEQRKAESQ 821
                :..:..:..||||           |:....|...|   |..|:..||.|::...::..:..
 Worm   729 ----TYQKNRNRATIRRPGYSRKRNEMEKSGGHDDDSLKPLTYADIITRLVARFIHQTKKDMKMD 789

  Fly   822 GVTEDDVNEIKQDISAFRCEL--------------VEILKNSGMDTNVTAGQGGGGGKKNRQKER 872
            ||.|||::|||||||:.|.||              ::.:|...|.|..|..:...||.....|.|
 Worm   790 GVNEDDLHEIKQDISSLRYELRDDRRREIVRSSSHIDAVKRDIMRTMSTTSRRPYGGSMRLPKTR 854

  Fly   873 RLMKGFNIAPPGSTGSLAPVAEFSTSLDNYD-------NQHEILSSTLSTLFTPNFMHKRQQSQA 930
                             ..|||.|...|..|       ...|..|...|.|:.|
 Worm   855 -----------------PSVAEESEEDDKSDETSSTDEEADETRSRKSSVLYIP----------- 891

  Fly   931 GSGGGGSESPTTPTAPQGTQGAAMTASSQVTKYNKSALKPYNKRIAGHKKRWGTLIEAAKVGNVS 995
                     |...|.|                                    |.:.|.|.|...:
 Worm   892 ---------PVNSTLP------------------------------------GIISEEAPVKKST 911

  Fly   996 KMLGR---SKSEDSVCNSSHTST-----------PVHGQMRVTYAQNSPQQEYGYHGETSSTTIS 1046
            |....   ||..|...:.::||:           |.|..:|.|    .....:..:|....|:|.
 Worm   912 KRRASEADSKLPDRPLSDTYTSSFTPKLLPVFAQPPHSALRKT----DTSMSFPINGTALDTSIV 972

  Fly  1047 TP-----------TPTISVV-----------------------SNSPAAHAGVG 1066
            .|           .|.:.::                       |.|||:|:.||
 Worm   973 KPPRGVLRASQENLPAVELIETLKKEMNEKLDRLISGISENVKSPSPASHSHVG 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	315/815 (39%)
		ANK repeat	118..147	CDD:293786	15/29 (52%)
		ANK repeat	175..217	CDD:293786	16/45 (36%)
		TRP_CaM_bind1	865..>891	CDD:467881	2/25 (8%)
trp-1	NP_001367402.1	TRPV	38..809	CDD:454755	318/837 (38%)
		ANK repeat	89..119	CDD:293786	15/29 (52%)
		ANK repeat	149..195	CDD:293786	16/46 (35%)