Protein Alignment Trpgamma and trp

DIOPT Version :10

• Sequence 1: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_061506782.1
• Gene: trp / 1271910
• VectorBaseID: AGAMI1_004842
• Length: 1207
• Species: Anopheles gambiae
• Alignment Length: 1189
• Identity: 534/1189 - (44%)
• Similarity: 710/1189 - (59%)
• Gaps: 136/1189 - (11%)

  Fly    78 LTLEEKKFLLAVERGDMAGTRRMLQKAQD-TEYINVNCVDPLGRTALLMAIDNENLEMVELLINY 141
            ||..||:|||..||||.|..||::|:.:: .|..::||||||.|:||:.||:|||:|::.||:..
Mosquito    52 LTKTEKRFLLTAERGDCATVRRIIQENKEHPEEFDINCVDPLNRSALIAAIENENIELINLLLRE 116

  Fly   142 NVDTKDALLHSISEEFVEAVEVLL--DHENVTFHSEGN-HSWESASEDTSTFTPDITPLILAAHR 203
            .:..||||||:|.||:|||||.||  :.||   |..|. :|||:....:|:||.||||||||||:
Mosquito   117 GIKVKDALLHAIKEEYVEAVETLLLWEEEN---HVPGEPYSWEAVDRSSSSFTADITPLILAAHK 178

  Fly   204 DNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSKDPI 268
            :||||:||||||||.|||||||||||||||.|.::||||||:||||||:||:|.|||||||||||
Mosquito   179 NNYEILKILLDRGATLPMPHDVRCGCDECVTSSEQDSLRHSQSRINAYKALSSSSLIALSSKDPI 243

  Fly   269 LTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTGPV--YEH 331
            .|||.|||||||||.:|.||:.||.::|...|:||||||||.|||:||||:||..| |.|  :|.
Mosquito   244 STAFHLSWELRRLSRMETEFRAEYTQMRLAVQEFATALLDHARTSNELEIMLNFSP-GAVDNWEP 307

  Fly   332 GERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSL 396
            |||..|.|||||:..:||.||||.|||||||:||||||||||||::..|.:.:.::|.|||::|:
Mosquito   308 GERQTLERLKLALNHKQKMFVAHPNVQQLLAAIWYEGLPGFRRKSILGQIMQVAKLGTMFPVYSM 372

  Fly   397 AYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEELP 461
            .|::||.|.:|..|:|||:|||.|||||..||.||..||||:|.....||..|.:  .:.:.|..
Mosquito   373 IYMIAPNSEMGLFMKKPFVKFIVHSASYAFFLMLLGGASQRVEYLAIEWFGPDWA--QDILAEWK 435

  Fly   462 TK-RGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSF 525
            .| ||:.|...|.|::.::..|||.|:|.||:.||.||::|:||::||::|:.|:..::||..|:
Mosquito   436 RKERGSLPGMFECLVILYIISLIWHEMKSLWNDGLMEYVSDLWNIVDFISNTFYIVWMSLRFTSW 500

  Fly   526 FQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRM 590
            :.|.::.....:.. .|||:||.:||||:|||.|:|..|||.||||:|||:|||||||||||.||
Mosquito   501 YTVWRDAKAGLNPW-YPREQWDPFDPMLLSEGAFAAGMIFSFLKLVHIFSINPHLGPLQVSLGRM 564

  Fly   591 VMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFS 655
            ::||:||||:|.|||||||.||||||||||.|||.:|..:.  |.|.:.:  |:..||.:||||:
Mosquito   565 IIDIIKFFFIYTLVLFAFGCGLNQLLWYYAVLEKNKCYHLP--SGLPDFD--NNEKACAIWRRFA 625

  Fly   656 NLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLI 720
            |||||:|:||||.|||:||.:|||.|||.|||||.:||||:||||||:||||:|||||::|||:|
Mosquito   626 NLFETSQSLFWASFGLVDLMAFELSGIKSFTRFWALLMFGSYSVINIIVLLNMLIAMMSNSYQII 690

  Fly   721 SERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSSAARREHLKTI 785
            |||:|.|||||||:||:||||:|.|.|||||:.|:.|:.....|      ||....:....:|..
Mosquito   691 SERSDTEWKFARSRLWMSYFEDGDTLPPPFNLFPSIKNFTNLCK------CSNDKRSTTSIIKRN 749

  Fly   786 RRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAESQGVTEDDVNEIKQDISAFRCELVEILKNSG 850
            |.|||:      :::.:|:.|||||||.||||.:..|:|||||.||:||||..|.||::||..:|
Mosquito   750 REKAQR------RHENVMKLLVRRYVTAEQRKRDDFGITEDDVMEIRQDISTLRYELIDILHQNG 808

  Fly   851 MDT-NVTAGQGGGGGKKNRQKERRLMKGFNIA-------PPGSTGSLAPVAEFSTSLDNYDNQHE 907
            |.| |:...:....|||.|..|||::|.|.|.       ...:|.|..|...|||......|:
Mosquito   809 MRTPNLKPNENAIAGKKGRVMERRILKDFQIGFVEGILQDTFATPSEKPADVFSTIAKAIGNK-- 871

  Fly   908 ILSSTLSTLFTPNFMHK--RQQSQAGSGGGGSESPTTPTAPQGTQGAAMTASSQVTKYNKSALKP 970
              |||...  .|...:.  |:.:.|....|.|.......:.|..:...:..|::..:.:...|..
Mosquito   872 --SSTKKK--KPEDWNALVRRSTVARDPIGNSTEAIMRRSRQSLRKQILDNSNKGLEMDTDHLVE 932

  Fly   971 YNKRIAGHKKRWGTLIEAAKVGNVSKMLGRSKSEDS----------VCNSSHTSTPV-HGQMRVT 1024
            ||.:::       .:....:|..|..|..:.|.:.:          ...:|.|||.. ..:.|.|
Mosquito   933 YNPKLS-------EVTPVTRVAYVKFMTTKMKKDAADVAAATAAAEAAGASETSTSTFENERRQT 990

  Fly  1025 YAQNS------------------------PQQEYGYHGE--TSSTTISTPTPTISVVSNSPAAHA 1063
            :.::|                        .:||.....|  |::.|:..|.|.      .||..|
Mosquito   991 WKRSSLKNLVDMKDKISDLEASGEQPPVPDEQEAAEPAEPTTATVTVEEPHPA------EPAPEA 1049

  Fly  1064 GVGSHFFHTTSGLTAIAALK-RKRKKFSSSKN-------IC--------PVTE---SVAAANAAE 1109
                   ....|:.|....| |.|.......|       .|        |:.|   |....|:.|
Mosquito  1050 -------EPLEGVRAEPRPKVRVRSPIIEDPNEEREDTPCCASPPPPPDPIPERPVSPIPPNSPE 1107

  Fly  1110 ILNDKTLKRVSSYPAAEAGVQHNPAQLVKPRRHE---------QTQSQHDSVETNST-----FTL 1160
            ......::..|..|||.|......:.....|..|         .|:|......|.|:     .||
Mosquito  1108 RHPVPEIESPSPPPAAAAAASGTKSPEGSARCQETLSPTGSTKSTESVRPKPATPSSKAPERLTL 1172

  Fly  1161 SIDPSNTSVNSREPLISTS 1179
            |..||..|.::..|:.|.|
Mosquito  1173 SPTPSGPSEDTGGPMASPS 1191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	443/769 (58%)
		ANK repeat	118..147	CDD:293786	12/28 (43%)
		ANK repeat	175..217	CDD:293786	27/42 (64%)
		TRP_CaM_bind1	865..>891	CDD:467881	11/32 (34%)
trp	XP_061506782.1	None