DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trpgamma and trpc7b

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001276815.1	Gene:	trpc7b / 102725540	ZFINID:	ZDB-GENE-140129-2	Length:	844	Species:	Danio rerio

Alignment Length:	853	Identity:	326/853 - (38%)
Similarity:	478/853 - (56%)	Gaps:	112/853 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KRHSIHG---MMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVD 116
            :|.::.|   |..|..|        .||.||::|:.|.|.|::...|:||   .:::.:|.||||
Zfish    13 RRQAVRGPAYMFNERGT--------SLTAEEERFMDAAEYGNIPVVRKML---DESKTLNFNCVD 66

  Fly   117 PLGRTALLMAIDNENLEMVELLINYNVDTK--DALLHSISEEFVEAVEVLLDHE------NVTF- 172
            .:|:.||.:|:.||:||:.|||:..:...:  ||||.:||:.:|..||.:|.|.      .:|.
Zfish    67 YMGQNALQLAVGNEHLEVTELLLKKDGMARIGDALLLAISKGYVRIVEAILAHPAFAGGLRLTLS 131

  Fly   173 ---HSEGNHSWESASEDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQ 234
               ....:..:.:..||.:.|:.|:||:|||||...|||:.|||.:||.:..|||..|.|:||::
Zfish   132 PLEQELRDDDFYAYDEDGTRFSHDVTPVILAAHCQEYEIVHILLMKGARIERPHDYFCKCNECME 196

  Fly   235 SRQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQC 299
            .::.||..|||||:|||:.|||.:.::|||:||:|||.|||.||.||:.:|.||||:|::|..||
Zfish   197 KQRRDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQC 261

  Fly   300 QDFATALLDHTRTSHELEILLNHDPTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASI 364
            :||...:||..|.:.|:|.:||.|.........:|..|:|:||:||...||||||.|.||.|.:|
Zfish   262 KDFVVGVLDLCRDTEEVEAILNGDVDQNPPAELQRPCLSRIKLSIKYEVKKFVAHPNCQQQLLTI 326

  Fly   365 WYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLF 429
            |||.|.|.|::::.::.:.::.:.:..|..::||.:.|.|.:||.:|.||:||:.|:.|:..||.
Zfish   327 WYENLSGLRQQSIGVKCLTVLGVTVGLPFLAIAYWIMPCSKLGQILRSPFMKFVAHAVSFTIFLA 391

  Fly   430 LLML-ASQRIETFIGGWFFADSSGMLNTMEELPTKR-----GAKPTFIEW---LILAWVSGLIWS 485
            ||:| ||.|.|            |:.|...|..|..     ..|.|...|   ||:.||.|:|||
Zfish   392 LLVLNASDRFE------------GVKNLPNETITDHPRQVFRVKTTQFSWTELLIMKWVLGMIWS 444

  Fly   486 EVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQKEMIY-NSHA-------TDLP 542
            |.|::|..|.:||:..:|||:||...|::||:...|:::|.:..|..:| :.|.       ..||
Zfish   445 ECKEIWVDGPREYVMHLWNVLDFGMLSIFVASFTARLMAFLKASKAQLYVDLHVPNHDISNASLP 509

  Fly   543 ---------RERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFF 598
                     |.||...||.:|||||::.|.:.|..::.||...|...||||:||.|.|.||.||.
Zfish   510 ADVAYFTYARNRWRPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFM 574

  Fly   599 FLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQT 663
            .::::|..||..|:..|..||  |..|..|                        .|:.:.|:.:|
Zfish   575 VIFIMVFVAFMIGMFNLYSYY--LGAKYNP------------------------AFTTVEESFKT 613

  Fly   664 LFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADVEW 728
            |||::|||.::.|..|.....|....|.:::|.|:|..:|||||:||||:|.|||.|.|.|||||
Zfish   614 LFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINSSYQEIEEDADVEW 678

  Fly   729 KFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRV---FCSGSSAARREHLKTIRRKAQ 790
            ||||:|||:|||:||.|.|.|||::|||||.:|.|..::..   .|.|.:......|:.....::
Zfish   679 KFARAKLWLSYFDEGRTLPAPFNLVPTPKSFYYLIIRIKTCLIHLCKGKAHRHDSELEMGMINSR 743

  Fly   791 QASDR-------------------DFKYQQIMRNLVRRYVTVEQRKAESQGVTEDDVNEIKQDIS 836
            |..||                   ..:||:||:.|::|||...|...|:..|.|.::.|||||||
Zfish   744 QKVDRHRVNLRSREESTLKKPIKHPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDIS 808

  Fly   837 AFRCELVE 844
            :.|.||:|
Zfish   809 SLRYELLE 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	318/823 (39%)
		ANK	113..>217	CDD:238125	44/115 (38%)
		ANK repeat	118..147	CDD:293786	11/30 (37%)
		ANK repeat	175..217	CDD:293786	17/41 (41%)
		TRP_2	227..286	CDD:285535	32/58 (55%)
		RRT14	<778..892	CDD:293680	27/86 (31%)
trpc7b	NP_001276815.1	trp	18..813	CDD:273311	322/843 (38%)
		ANK repeat	38..66	CDD:293786	10/30 (33%)
		ANK	41..175	CDD:238125	49/136 (36%)
		ANK repeat	68..99	CDD:293786	11/30 (37%)
		ANK repeat	100..146	CDD:293786	11/45 (24%)
		ANK repeat	148..183	CDD:293786	18/34 (53%)
		TRP_2	189..247	CDD:285535	32/57 (56%)
		TPX2_importin	724..>794	CDD:289022	16/69 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910