Protein Alignment Trpgamma and trpc4a

DIOPT Version :10

• Sequence 1: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_073769573.1
• Gene: trpc4a / 102725537
• ZFINID: ZDB-GENE-131217-1
• Length: 991
• Species: Danio rerio
• Alignment Length: 1070
• Identity: 446/1070 - (41%)
• Similarity: 608/1070 - (56%)
• Gaps: 200/1070 - (18%)

  Fly    69 IRPHQEIRQLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLE 133
            :|...|:..|   ||.:|.|||:||....::.|.:|:....||:||:|||||||||:||:|||||
Zfish    23 VRSESELSPL---EKAYLWAVEKGDYGSVKQALIEAEIYFKININCIDPLGRTALLIAIENENLE 84

  Fly   134 MVELLINYNVDTKDALLHSISEEFVEAVEVLLDHENVTFHSEGNHSWESASEDT--STFTPDITP 196
            ::|||:::||...|||||:|.:|.|.|||:||:|:.    ..|.........|.  |.|||||||
Zfish    85 IIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHKK----PSGGMQVPPILLDKQFSDFTPDITP 145

  Fly   197 LILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIA 261
            :|||||.:||||||:|:.:|..:|.||.|||.|.|||.|...|||||||||:|.|||||||||:|
Zfish   146 IILAAHTNNYEIIKMLVQKGVSMPQPHQVRCNCMECVSSSDVDSLRHSRSRLNIYRALASPSLVA 210

  Fly   262 LSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTG 326
            |||:||.||||:|||||:.||.:|:|||:||:||.:||:.||..|||.||:|.|||::||:....
Zfish   211 LSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSQQCKQFAKDLLDQTRSSRELELILNYKDDI 275

  Fly   327 PVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMF 391
            .:.|......|.|||||||..||:|||..|.||||||.||:..||:||::.|.:.:..|.||::|
Zfish   276 NLLEDEGINDLARLKLAIKYHQKEFVAQPNCQQLLASRWYDEFPGWRRRHWASKFMTCIFIGLLF 340

  Fly   392 PIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNT 456
            |.|||.|::||.|..|..:||||||||||:|||.||||||:||||.:           :..:|:.
Zfish   341 PFFSLFYLIAPKSHYGLFIRKPFIKFICHTASYLTFLFLLLLASQHV-----------NRNLLDQ 394

  Fly   457 MEELPTK-----RGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVA 516
            .|....|     :...||.:||:||.||.|.:|:|:||:||.|.|:|::|.||::|||.||||:|
Zfish   395 DENSDCKNENLRQNLAPTTVEWMILPWVLGFVWAEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLA 459

  Fly   517 TVALRVVSFFQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLG 581
            |::|::|:..:      ||:..    |:.||.|.|.|:.|.||:.|||||||:|:.:|:.|.|||
Zfish   460 TISLKIVALSK------YNNQC----RDEWDMWHPALVGEALFAIANIFSSLRLISLFTANSHLG 514

  Fly   582 PLQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKK---------RCPEVSPMSALL 637
            |||:||.||::||:||.|:|.|||.||.:|||||.:||....|.         ||.|.:
Zfish   515 PLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYESDGKTSNNVTCKGIRCSEQN------ 573

  Fly   638 NMNGTNDPNACIVWRRFSNLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINI 702
                    ||      |:.:|||.|:|||::|||:.|....:|....||.|.|..||||||:|::
Zfish   574 --------NA------FTTMFETLQSLFWSIFGLVALHVTNVDAKHDFTEFVGATMFGTYSIISL 624

  Fly   703 VVLLNLLIAMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWM- 766
            |||||:||||||:|||.|::.||:||||||:|||:||||||||.|||||::|:|||.||.|:|:
Zfish   625 VVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNVVPSPKSAWYLIRWIK 689

  Fly   767 ---------RRVFCSGSSAARREHL------------------------------------KTIR 786
                     :|....||...|...|                                    :::.
Zfish   690 THCFKIKQRKRTETLGSLGVRGHFLLMLYSFIFHYMLTNFLFTEYYIYINNAFGFHYHIIKQSVL 754

  Fly   787 RKAQQ--------ASDR---DFKYQQIMRNLVRRYVTVEQRKA-ESQGVTEDDVNEIKQDISAFR 839
            :||.|        |::.   :.:||:::||||:|||....|.| :.:|:|||:..|:|||||:||
Zfish   755 KKAIQLFSFVQIRAAENVRTNRQYQEVLRNLVKRYVAARIRDAKKEEGLTEDNFKELKQDISSFR 819

  Fly   840 CELVEILK--NSGMDTNVTAGQGGGGGKKNRQKERRLMKGFNIAPPGSTGSLAPVAEFSTSLDNY 902
            .|::.::|  .:||.|:           |....|..|:...|.....||
Zfish   820 YEVMGMMKGTKTGMSTS-----------KGNTAESSLVYPENALKCNST---------------- 857

  Fly   903 DNQHEILSSTLSTLFTPNFMHKRQQSQAGSGGGGSESPTTPTAPQGTQGAAMTASSQVTKYNKSA 967
                    ||.|||.....:.....:....||..:..||         |.:..|.|.|.
Zfish   858 --------STGSTLKGKMRLQSITNTMIQEGGPKAWKPT---------GCSNLADSSVP------ 899

  Fly   968 LKPYNKRIAGHKKRWGTLIEAAKVGNVSKMLGRSKSEDS---------VCNSSH----------T 1013
                ||.|: |:..........::.:||:..|.|:||:.         .|....          .
Zfish   900 ----NKNIS-HQLNCKGPNNPGEMYSVSEEAGESESEEQGDGKQAENLDCKKKKNQNKETEKDGV 959

  Fly  1014 STPVHGQMRVTYAQNSPQQEY--GYHGETS 1041
            :..|.....:||.:...::|.  |..||||
Zfish   960 NNDVEEDEELTYMRYMCEEEMNEGNEGETS 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	400/837 (48%)
		ANK repeat	118..147	CDD:293786	19/28 (68%)
		ANK repeat	175..217	CDD:293786	22/43 (51%)
		TRP_CaM_bind1	865..>891	CDD:467881	6/25 (24%)
trpc4a	XP_073769573.1	None