DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trpgamma and trpc4b

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	NP_001276810.1	Gene:	trpc4b / 102725536	ZFINID:	ZDB-GENE-120329-1	Length:	915	Species:	Danio rerio

Alignment Length:	878	Identity:	418/878 - (47%)
Similarity:	573/878 - (65%)	Gaps:	87/878 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGRTALLMAIDNENLEMVELLINY 141
            :|:.:||.:|.|||:||.|..:..|::|:....||:||:|||||||||:||:|||||::|||:::
Zfish    28 ELSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAIENENLEIIELLLSF 92

  Fly   142 NVDTKDALLHSISEEFVEAVEVLLDHENVTFHSEGNHSWES------ASEDTSTFTPDITPLILA 200
            ||...|||||:|.:|.|.|||:||:|:        ..|.|.      ..:..|.|||||||:|||
Zfish    93 NVYVGDALLHAIRKEVVGAVELLLNHK--------KPSGEKQVPPILLDKQFSDFTPDITPIILA 149

  Fly   201 AHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHSRSRINAYRALASPSLIALSSK 265
            ||.:||||||:|:.:|..:|.||:|||.|.|||.|...|||||||||:|.|:||||||||||||:
Zfish   150 AHTNNYEIIKMLVQKGVSVPQPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSE 214

  Fly   266 DPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNHDPTGPVYE 330
            ||.||||:|||||:.||.:|:|||.||:||..||:.||..|||.||:|.|||::||......:.:
Zfish   215 DPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLLDQTRSSRELELILNFRDDMNLLQ 279

  Fly   331 HGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFS 395
            ......|.|||||||.|||:|||..|.||||||.||:..||:||::.|.:.:..:.||:|||:.|
Zfish   280 DEANNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAGKLITCVFIGLMFPLLS 344

  Fly   396 LAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTMEEL 460
            |.|::||.|..|..:||||||||||:|||.||||||:||||.|                  :...
Zfish   345 LCYLVAPKSRYGLFIRKPFIKFICHTASYLTFLFLLLLASQHI------------------VSNN 391

  Fly   461 PTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSF 525
            |.::|.|||.:||:||.||.|.||:|:||:||.|.|:|::|.||::|||.||||:||::|::|:
Zfish   392 PDRQGPKPTTVEWMILPWVLGFIWTEIKQMWDGGFQDYIHDWWNLMDFVMNSLYLATISLKIVA- 455

  Fly   526 FQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRM 590
                    |..::...||:.|:.|.|.|::|.:|:.|||||||:|:.:|:.|.||||||:||.||
Zfish   456 --------YVKYSGCKPRDTWEMWHPTLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRM 512

  Fly   591 VMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFS 655
            ::||:||.|:|.|||.||.:|||||.:||.:.|...|.         .:......||      ||
Zfish   513 LLDILKFLFIYCLVLLAFANGLNQLYFYYENSEGMTCK---------GIRCERQNNA------FS 562

  Fly   656 NLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLI 720
            .||||.|:|||::||||.|....:.....||.|.|..|||||:||::|||||:||||||:|||.|
Zfish   563 TLFETLQSLFWSIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQHI 627

  Fly   721 SERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWYAIKWMR-RVFCSGSSAARREHLKT 784
            ::.||:||||||:|||:||||||||.||||||||:||||.|.|.|:: .||...|.  |.|...|
Zfish   628 ADHADIEWKFARTKLWMSYFEEGGTLPPPFNIIPSPKSICYLITWIKVHVFKRRSK--RTETFGT 690

  Fly   785 IRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAES-QGVTEDDVNEIKQDISAFRCELVEILKN 848
            :.|:|.:....:.:||:::||||:|||....|.|:: :|:||::..|:|||||:||.|::.::|
Zfish   691 LGRRAAENVRLNHQYQEVLRNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMMK- 754

  Fly   849 SGMDTNVTAGQGGGGGKKNRQKERRLMKGFNIAPPGSTGSLAPVAEFSTSLDNYDNQHEILSSTL 913
                          |.:|:.:..:......:::.|  .|||    ::|::|......|      |
Zfish   755 --------------GNRKSTRANKSDTSASDVSHP--EGSL----QYSSALKQNSKLH------L 793

  Fly   914 STLFTPNFMHKRQQSQAGSGGGGSESPTTPTAP 946
            ..:.|.......::::|..|...:.|....|.|
Zfish   794 YDVTTALQQQNSEEAKASLGCLANGSAVVLTEP 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	400/771 (52%)
		ANK	113..>217	CDD:238125	59/109 (54%)
		ANK repeat	118..147	CDD:293786	19/28 (68%)
		ANK repeat	175..217	CDD:293786	22/47 (47%)
		TRP_2	227..286	CDD:285535	42/58 (72%)
		RRT14	<778..892	CDD:293680	35/114 (31%)
trpc4b	NP_001276810.1	trp	17..748	CDD:273311	400/771 (52%)
		ANK repeat	70..98	CDD:293786	18/27 (67%)
		ANK repeat	99..133	CDD:293786	15/41 (37%)
		ANK repeat	135..166	CDD:293786	20/30 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581914
Domainoid	1	1.000	270	1.000	Domainoid score	I1782
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	774	1.000	Inparanoid score	I517
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm6331
orthoMCL	1	0.900	-	-		OOG6_102173
Panther	1	1.100	-	-	LDO	PTHR10117
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900