DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trpgamma and trpc6b

DIOPT Version :9

Sequence 1:	NP_001137830.2	Gene:	Trpgamma / 34991	FlyBaseID:	FBgn0032593	Length:	1188	Species:	Drosophila melanogaster
Sequence 2:	XP_002665445.2	Gene:	trpc6b / 102725535	ZFINID:	ZDB-GENE-081030-19	Length:	858	Species:	Danio rerio

Alignment Length:	871	Identity:	328/871 - (37%)
Similarity:	487/871 - (55%)	Gaps:	116/871 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RRVKRHSIHGMMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVD 116
            |...|...|......|.:.|         .|::||.|.|.|::...||||::..:   :||||||
Zfish    46 RMAMRRPAHMFNARYNNLSP---------TEERFLEAAEYGNIPVIRRMLEELPE---LNVNCVD 98

  Fly   117 PLGRTALLMAIDNENLEMVELLINYN--VDTKDALLHSISEEFVEAVEVLLDHE---------NV 170
            .:|:.||.:|:.||:||:.|||:...  ....||||.:||:.::..||.:|.|:         :.
Zfish    99 YMGQNALQLAVANEHLEVTELLLKKENLARIGDALLLAISKGYIRIVEAILSHQAFADTTKLTSS 163

  Fly   171 TFHSEGNHSWESASEDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQS 235
            ...:|....:.:..||.:.|:.||||:|||:|...|||:.|||.:||.:..|||..|.|:.|:..
Zfish   164 PLQAETQDDFFAYDEDGTRFSHDITPIILASHCHEYEIVHILLRKGACIARPHDYFCKCNGCLYH 228

  Fly   236 RQEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQ 300
            ::.||..|||||||||:.||||:.::|||:||:|||.|||.||..|:.:|.||||:|:.|..||:
Zfish   229 QRHDSFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAVLANIEKEFKNDYKTLSMQCK 293

  Fly   301 DFATALLDHTRTSHELEILLNHD-PTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASI 364
            ||...|||..|.:.|:|.:||.| ..|..::.|:|.:|.|||||||...||||||.|.||.|.||
Zfish   294 DFVVGLLDLCRNTEEVEAILNGDTEAGGHFDKGDRPNLVRLKLAIKYELKKFVAHPNCQQQLLSI 358

  Fly   365 WYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFL- 428
            |||.|.|.|::..|::.:.::.:.:..||.:|.|.:||.|.:|:.:|.||:||:.|:||:..||
Zfish   359 WYENLSGLRQQTTAVKLLVVLGVVVGLPILALLYWIAPSSKLGKIIRGPFLKFVAHAASFTIFLG 423

  Fly   429 FLLMLASQRIE--TFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWSEVKQLW 491
            .|:|.|:.|.|  :.:......|....|..|:..|.      |::|.||::||.|:||:|.|::|
Zfish   424 LLIMNAADRFEGTSLLPNMTIHDHPSQLFRMKTTPF------TWMEMLIISWVVGMIWAECKEIW 482

  Fly   492 DVGLQEYLNDMWNVIDFVTNSLYVATVALRVVSFFQVQKEMIY-NSHATD--------------L 541
            .:|.:|||.:.||::||...:::|.:...|.::|:.......| :...||              |
Zfish   483 SLGPREYLLEPWNLLDFGMLAIFVTSFIARFMAFYHANVAQNYVDKRYTDLSNITLPLEIEYYRL 547

  Fly   542 PRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFFLYVLVLF 606
            .|..|...||.||||||::.|.:.|..::.||...|...||||:||.|.|.||.||..::::|..
Zfish   548 ARVHWVPSDPQLISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFV 612

  Fly   607 AFGSGLNQLLWYYADLEKKRCPEVSPMSALLNMNGTNDPNACIVWRRFSNLFETTQTLFWAVFGL 671
            ||..|:..|..||...::               ||.           |:.:.|:.:|||||:|||
Zfish   613 AFMIGMFNLYSYYRGAKQ---------------NGA-----------FTTVEESFKTLFWAIFGL 651

  Fly   672 IDLDSFELDGIKIFTRFWGMLMFGTYSVINIVVLLNLLIAMMNHSYQLISERADVEWKFARSKLW 736
            .::.|..::....|....|.:::|.|:|..::||||:||||:|:|:|.|.:.|||||||||:|||
Zfish   652 SEVKSVVINNGHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINNSFQEIEDDADVEWKFARAKLW 716

  Fly   737 ISYFEEGGTCPPPFNIIPTPKSIWYAIKWMRRVFCSGSSAARREHLKTIRR--------KAQQAS 793
            .||||||||.|.|||:||:|||:......::|:..    .....|.:.::.        |.:::|
Zfish   717 FSYFEEGGTLPVPFNLIPSPKSVISLAMRLKRLLL----IPLHRHKEDLKEDTELNESGKQKESS 777

  Fly   794 DRD----FKYQQIMRNLVRRYVTVEQRKAESQGVTEDDVNEIKQDISAFRCELVEILKNSGMDTN 854
            :::    .:||:||:.|::|||...|...|...|.|.::.|||||||:.|.||:|
Zfish   778 EKNSPHTSRYQRIMKRLIKRYVIKAQTDKEGDEVNEGELKEIKQDISSLRFELLE---------- 832

  Fly   855 VTAGQGGGGGKKNRQKE------RRL 874
                      :|:||.|      |||
Zfish   833 ----------EKSRQTEELAELVRRL 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	313/805 (39%)
		ANK	113..>217	CDD:238125	43/114 (38%)
		ANK repeat	118..147	CDD:293786	11/30 (37%)
		ANK repeat	175..217	CDD:293786	18/41 (44%)
		TRP_2	227..286	CDD:285535	32/58 (55%)
		RRT14	<778..892	CDD:293680	33/115 (29%)
trpc6b	XP_002665445.2	trp	50..829	CDD:273311	317/826 (38%)
		ANK	73..206	CDD:238125	50/135 (37%)
		ANK repeat	100..131	CDD:293786	11/30 (37%)
		ANK repeat	179..210	CDD:293786	16/30 (53%)
		TRP_2	220..279	CDD:285535	32/58 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.870