Protein Alignment Trpgamma and trpc4

DIOPT Version :9

• Sequence 1: NP_001137830.2
• Gene: Trpgamma / 34991
• FlyBaseID: FBgn0032593
• Length: 1188
• Species: Drosophila melanogaster
• Sequence 2: XP_002939629.3
• Gene: trpc4 / 100485338
• XenbaseID: XB-GENE-1013618
• Length: 969
• Species: Xenopus tropicalis
• Alignment Length: 1039
• Identity: 450/1039 - (43%)
• Similarity: 626/1039 - (60%)
• Gaps: 128/1039 - (12%)

  Fly    65 EENTIRPHQE------IR---QLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEYINVNCVDPLGR 120
            :.||..|:|:      :|   :|:..||.:|.|||:||.|..::.|::|:....||:||:|||||
 Frog     7 KRNTNSPYQDRIPLRIVRSESELSPSEKAYLSAVEKGDYASVKQALEEAEIYFKININCIDPLGR 71

  Fly   121 TALLMAIDNENLEMVELLINYNVDTKDALLHSISEEFVEAVEVLLDHENVTFHSEGNHSWES--- 182
            ||||:||:|||||::|||::|||...|||||:|.:|.|.|||:||:|:        ..|.|.
 Frog    72 TALLIAIENENLELIELLLSYNVYVGDALLHAIRKEVVGAVELLLNHK--------KPSGEKQVP 128

  Fly   183 ---ASEDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGCDECVQSRQEDSLRHS 244
               ..:..|.|||||||:|||||.:||||||.|:.:|..:|.||:|||.|.|||.....||||||
 Frog   129 PILLDKQFSEFTPDITPIILAAHTNNYEIIKHLVQKGVSVPRPHEVRCNCVECVSGSDVDSLRHS 193

  Fly   245 RSRINAYRALASPSLIALSSKDPILTAFELSWELRRLSFLEHEFKNEYQELRKQCQDFATALLDH 309
            |||:|.||||:|||||||||:||.||||:|||||:.||.:|:|||:||:||..||:.||..|||.
 Frog   194 RSRLNIYRALSSPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYEELSSQCKQFAKDLLDQ 258

  Fly   310 TRTSHELEILLNHDPTGPVYEHGERMHLNRLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRR 374
            ||:|.||||:||:...|.:.:......|.|||||||.|||:|||..|.||||||.||:..||:||
 Frog   259 TRSSRELEIILNYRDDGGLLDDSNGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRR 323

  Fly   375 KNMALQAVDIIRIGIMFPIFSLAYILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIE 439
            ::..::.|..:.:|::||.||..|::||.|:.|..:||||||||||:|||.||||||:||||.|
 Frog   324 RHWVVKMVTCVIVGLLFPAFSCCYLIAPKSTFGLFIRKPFIKFICHTASYLTFLFLLLLASQNI- 387

  Fly   440 TFIGGWFFADSSGMLNTMEELPTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWN 504
                           |..|.|   :|..||.:||:||.||.|.||.|:||:||.|.|:|::|.||
 Frog   388 ---------------NKTESL---QGPAPTIVEWMILPWVLGFIWGEIKQMWDGGFQDYIHDWWN 434

  Fly   505 VIDFVTNSLYVATVALRVVSF--FQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSS 567
            ::|||.||||:||::|::|::  |..|:.           |..|:.:.|.|::|.:|:.||||||
 Frog   435 LMDFVMNSLYLATISLKIVAYVKFHGQRN-----------RAEWEMFHPTLVAEAVFAIANIFSS 488

  Fly   568 LKLVYIFSVNPHLGPLQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYY-ADLEKKRCPEVS 631
            |:|:.:|:.|.||||||:||.||::||:||.|:|.|||.||.:|||||.:|| ||.:...|.
 Frog   489 LRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEADAKSSGCK--- 550

  Fly   632 PMSALLNMNGTNDPNACIVWRRFSNLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGT 696
                  .:......||      ||.||||.|:|||::||||:|....:|....||.|.|..||||
 Frog   551 ------GIRCEKQNNA------FSTLFETLQSLFWSIFGLINLYVTNVDPKHEFTEFVGATMFGT 603

  Fly   697 YSVINIVVLLNLLIAMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKSIWY 761
            |:||::|||||:||||||:|||||::.||:||||||:|||:||||||||.|.||||||:|||:||
 Frog   604 YNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNIIPSPKSLWY 668

  Fly   762 AIKWMRRVFCSGSSAARREHLKTIRRKAQQASDRDFKYQQIMRNLVRRYVTVEQRKAES-QGVTE 825
            .|||:|:..|......:.|....|.|:|.....|...||::|:|||:|||....|.|:: :|:||
 Frog   669 LIKWIRKQICKKKMKRKPESFGAIGRRAADNLRRHNHYQEVMKNLVKRYVAAMIRDAKTEEGLTE 733

  Fly   826 DDVNEIKQDISAFRCELVEILKNSGMDTNVTAGQGGGGG-----KKNRQKERR---LMKGFNIAP 882
            ::..|:|||||:||.|::.:||.:..:...:....|.|.     :|::.||:|   ..|.|::.
 Frog   734 ENFKELKQDISSFRFEVLGLLKGNKFNIQSSKMNNGIGDIQETEEKSKIKEKRSRTQKKNFSLF- 797

  Fly   883 PGSTGSLAP-VAEFSTSLDN-YDNQHEILSSTL-----------STLFTPNFMHKRQQSQAGSGG 934
             ..|..:.| .|..::.:.| ..|...:|:|.|           :.:.:....|||.:|
 Frog   798 -DITTMIHPKSAVIASDVHNSVSNGSALLASELVKEKQRKNSFVTDIKSFGLFHKRSKS------ 855

  Fly   935 GGSESPTTPTAPQGTQGAA----MTASSQVTKYNKSALKPYNKRIAGHKKRWGTLIEAAKVGNVS 995
             ....|.:.|....::..|    |......|.......:|.:..:                 ||:
 Frog   856 -NFSDPISKTIYSVSEEVANQQDMELGDNTTDLQVKESEPASCEL-----------------NVN 902

  Fly   996 KMLGRSKSEDSVCNSSHTSTP-----VHGQMRVTYAQNSPQQEYGYHGETSSTTISTPTPTISV 1054
            |:..:.....|..|:|...:|     .|..:.:........:.....|:.:|||:.:|....|:
 Frog   903 KLTEQYALSPSSVNTSEIPSPQPSDSQHSSVALNEHSTDALKHMDSPGDENSTTVESPNEQDSI 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpgamma	NP_001137830.2	trp	77..841	CDD:273311	402/773 (52%)
		ANK	113..>217	CDD:238125	60/109 (55%)
		ANK repeat	118..147	CDD:293786	20/28 (71%)
		ANK repeat	175..217	CDD:293786	22/47 (47%)
		TRP_2	227..286	CDD:285535	41/58 (71%)
		RRT14	<778..892	CDD:293680	40/123 (33%)
trpc4	XP_002939629.3	trp	17..749	CDD:273311	403/784 (51%)
		ANK repeat	69..133	CDD:293786	36/71 (51%)
		ANK repeat	135..166	CDD:293786	20/30 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	263	1.000	Domainoid score	I1896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22955
Inparanoid	1	1.050	784	1.000	Inparanoid score	I514
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355630at33208
OrthoFinder	1	1.000	-	-		FOG0000660
OrthoInspector	1	1.000	-	-		mtm9358
Panther	1	1.100	-	-	LDO	PTHR10117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2373
SonicParanoid	1	1.000	-	-		X802
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100