DRSC/TRiP Functional Genomics Resources

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Protein Alignment mtgo and MYOM2

DIOPT Version :10

Sequence 1:NP_001137829.1 Gene:mtgo / 34987 FlyBaseID:FBgn0259735 Length:2064 Species:Drosophila melanogaster
Sequence 2:NP_003961.3 Gene:MYOM2 / 9172 HGNCID:7614 Length:1465 Species:Homo sapiens


Alignment Length:1185 Identity:250/1185 - (21%)
Similarity:364/1185 - (30%) Gaps:386/1185 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   839 VPLPGHLNNHHH----AVNHQGRRLPQQHQGQAHQVAQQQQSQARNGNPQHPQRAGS--SVGG-- 895
            |.:|.:...|.|    ..|.|.|.|..::..: .:.:.|..||.........|||.|  |:||  
Human     4 VTVPFYQKRHRHFDQSYRNIQTRYLLDEYASK-KRASTQASSQKSLSQRSSSQRASSQTSLGGTI 67

  Fly   896 ----ASSVGTSEDGEDN---------------------SSLAGDDEEEYHRENS----------- 924
                |..|.|.||.|..                     |.|| ..||:.|...|           
Human    68 CRVCAKRVSTQEDEEQENRSRYQSLVAAYGEAKRQRFLSELA-HLEEDVHLARSQARDKLDKYAI 131

  Fly   925 --IIEQISAIEKPEVIDVTSRAAKI--------IWESPAIANTVTVD------MRQLRYQVLLCD 973
              ::|...|.|:....:..|||.:|        :||..::....||.      ::..:...|:|.
Human   132 QQMMEDKLAWERHTFEERISRAPEILVRLRSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQ 196

  Fly   974 SGKQCKYK--SLYQGEAYECIVQDLQPGQDY-LVRLQVHYQKLTGTVSDPTEFRTPPCEPDQPPP 1035
            :.:..||:  |.|.....|....|......| .|....|.|..|........||     .|:.| 
Human   197 AAEPGKYRIESNYGVHTLEINRADFDDTATYSAVATNAHGQVSTNAAVVVRRFR-----GDEEP- 255

  Fly  1036 PKLVSRTKNSINLRWAAPAANGASIQHYLLEYDEG-----RMPG------------------QP- 1076
                   ..|:.|....|.::.....|:.:::.|.     |..|                  || 
Human   256 -------FRSVGLPIGLPLSSMIPYTHFDVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQPR 313

  Fly  1077 ----QKFVELAKIKAKHYVIGKLQPTTVYS---------FRLAAVNEAGQSPYSPVASYSTSGNP 1128
                :..|.|.:.|......|:.|.:..:|         :.|..|:..|.|.:|..         
Human   314 AEWYRDDVLLKESKWTKMFFGEGQASLSFSHLHKDDEGLYTLRIVSRGGVSDHSAF--------- 369

  Fly  1129 PPVPKPPQLLASSSSSLKLGWERRAQDGDFLLQLQDAETGHGFLNTYK----------------- 1176
                    |....:..|..|......|    ||..||...: .:.|:|                 
Human   370 --------LFVRDADPLVTGAPGAPMD----LQCHDANRDY-VIVTWKPPNTTTESPVMGYFVDR 421

  Fly  1177 ---GTELQTEC------------LQLRRASSYQFRLRSENEAGFSPWS---------PEVSYRTL 1217
               ||....:|            ..|....||.||:|:.|.||.|..|         ..:..|.|
Human   422 CEVGTNNWVQCNDAPVKICKYPVTGLFEGRSYIFRVRAVNSAGISRPSRVSDAVAALDPLDLRRL 486

  Fly  1218 ---------------------AERPGRPGKPHAKGKIHGTQFKARWDAPSDSGGAEILCYHLELS 1261
                                 |:.||.|...|| .:|........|:.|:.. |.:.|.|.:|.|
Human   487 QAVHLEGEKEIAIYQDDLEGDAQVPGPPTGVHA-SEISRNYVVLSWEPPTPR-GKDPLMYFIEKS 549

  Fly  1262 AAGP-AFERIYSGAETEAMCER-----LQPGTTYALRACCEGPAGQSPYSDIG---HVTTEAVPP 1317
            ..|. :::|:  .|:|.....|     |..|.:|..|.......|.|..|:|.   ......|.|
Human   550 VVGSGSWQRV--NAQTAVRSPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQAQDVTVVP 612

  Fly  1318 SAP------------------PPPHCSDPPSPY----AALLKL------RPPEYNGGAPILEFEA 1354
            |||                  .|.|..|....|    .|...|      :|..||          
Human   613 SAPGRVLASRNTKTSVVVQWDRPKHEEDLLGYYVDCCVAGTNLWEPCNHKPIGYN---------- 667

  Fly  1355 QMRRLEQVQPPQLVYRGKQTYFVAQDLTPGGMYETQVRAINRIGAGSWSQ---WMRFTAAAAAPG 1416
                                .||...||.|..|..:|:|:|.:|....||   .::..||...|.
Human   668 --------------------RFVVHGLTTGEQYIFRVKAVNAVGMSENSQESDVIKVQAALTVPS 712

  Fly  1417 VPEELRVLVKSATHLGVSWQPPLQENGAPVTSYTLKSASQERKEDDSEEEVKEPPSSEFHNCYQG 1481
            .|..:.:|......:.:.|:.|....|:|:..|.|.......|   :..||...||.        
Human   713 HPYGITLLNCDGHSMTLGWKVPKFSGGSPILGYYLDKREVHHK---NWHEVNSSPSK-------- 766

  Fly  1482 PQTCAELRNLSPYTRYHFRIQASNSAGTGNSSDVIS--VCTPAAVP-GAPQMQGYEFTAQEV--- 1540
             .|...:..|:..:.|.|:|.|.|.||.|..||...  .|....:| ..|   .|:.|..||   
Human   767 -PTILTVDGLTEGSLYEFKIAAVNLAGIGEPSDPSEHFKCEAWTMPEPGP---AYDLTFCEVRDT 827

  Fly  1541 --TLNWTQPAAHG-SPICSYNIEYGER------TIATPDACTRY-TVSGLMPETGYKFRVQAVNA 1595
              .:.|..|...| ||:..|.:::.|.      |:......:|| .||.|.....|.|||:||||
Human   828 SLVMLWKAPVYSGSSPVSGYFVDFREEDAGEWITVNQTTTASRYLKVSDLQQGKTYVFRVRAVNA 892

  Fly  1596 IGAGAFSAYAKLTTQPAPPAPPRLECSGAGHNYIKLKWGENGNGKVVNSNPSGNGGDFTKYFVEM 1660
            .|.|          :|:..:.|.|..:..|...|.....|.||                      
Human   893 NGVG----------KPSDTSEPVLVEARPGTKEISAGVDEQGN---------------------- 925

  Fly  1661 YVARAKQFQAVYSGTNCM----------CKVH---------KLQERSSYTFRIYAHTDRAGDGDY 1706
                      :|.|.:|.          ||.:         |::....::.....:.|:...|.|
Human   926 ----------IYLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGDHSKLYLKNPDKEDLGTY 980

  Fly  1707 SEEFVFETSATLPANIKPPRVVQEGSVCLMELPGQLGMQLTLEWQHSKNSFNDRVEYELQYAVLG 1771
            |.. |.:|.....:.:..|..::.    ||.|..::           ||. ...::.||.|.:..
Human   981 SVS-VSDTDGVSSSFVLDPEELER----LMALSNEI-----------KNP-TIPLKSELAYEIFD 1028

  Fly  1772 AAE----LEGESLSP 1782
            ...    |:.|.|||
Human  1029 KGRVRFWLQAEHLSP 1043

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mtgoNP_001137829.1 FN3 <937..>1125 CDD:442628 45/241 (19%)
FN3 1037..1124 CDD:238020 20/123 (16%)
FN3 <1149..1216 CDD:238020 21/107 (20%)
FN3 1221..1312 CDD:238020 26/99 (26%)
FN3 1334..1409 CDD:238020 17/83 (20%)
FN3 <1380..>1609 CDD:442628 68/247 (28%)
FN3 1619..1714 CDD:238020 17/113 (15%)
MYOM2NP_003961.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..61 7/22 (32%)
IgI_titin_I1-like 154..247 CDD:409543 18/92 (20%)
Ig strand A 154..156 CDD:409543 0/1 (0%)
Ig strand A' 158..164 CDD:409543 0/5 (0%)
Ig strand B 171..178 CDD:409543 1/6 (17%)
Ig strand C 184..189 CDD:409543 0/4 (0%)
Ig strand C' 191..194 CDD:409543 0/2 (0%)
Ig strand D 202..206 CDD:409543 2/3 (67%)
Ig strand E 211..218 CDD:409543 1/6 (17%)
Ig strand F 225..233 CDD:409543 2/7 (29%)
Ig strand G 236..247 CDD:409543 2/10 (20%)
Ig 290..372 CDD:472250 15/98 (15%)
Ig strand B 295..299 CDD:409353 0/3 (0%)
Ig strand C 313..317 CDD:409353 0/3 (0%)
Ig strand E 338..342 CDD:409353 0/3 (0%)
Ig strand F 352..357 CDD:409353 1/4 (25%)
Ig strand G 366..369 CDD:409353 1/2 (50%)
FN3 <402..818 CDD:442628 102/464 (22%)
FN3 <673..993 CDD:442628 88/377 (23%)
PHA02826 1233..1432 CDD:165173
IgI_M-protein_C 1344..1435 CDD:143299
Ig strand A 1344..1347 CDD:143299
Ig strand A' 1352..1357 CDD:143299
Ig strand B 1361..1368 CDD:143299
Ig strand C 1375..1380 CDD:143299
Ig strand C' 1383..1385 CDD:143299
Ig strand D 1390..1396 CDD:143299
Ig strand E 1400..1405 CDD:143299
Ig strand F 1415..1422 CDD:143299
Ig strand G 1425..1435 CDD:143299
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1442..1465
Blue background indicates that the domain is not in the aligned region.

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