DRSC/TRiP Functional Genomics Resources

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Protein Alignment mtgo and USH2A

DIOPT Version :10

Sequence 1:NP_001137829.1 Gene:mtgo / 34987 FlyBaseID:FBgn0259735 Length:2064 Species:Drosophila melanogaster
Sequence 2:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens


Alignment Length:1435 Identity:307/1435 - (21%)
Similarity:477/1435 - (33%) Gaps:421/1435 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   859 LPQQHQGQAHQVAQQQQSQARNGNPQHPQRAGSSVGGASSVG-TSEDGEDNS------------- 909
            ||::..|   .|:|.|.|  ||||...       :||:.... |.::.|.||             
Human  3704 LPEKPNG---LVSQYQLS--RNGNLLF-------LGGSEEQNFTDKNLEPNSRYTYKLEVKTGGG 3756

  Fly   910 SLAGDD----------EEEYHRENSIIEQISAIEKPEVIDVTSRAAKIIWESPAIANTVTVDMRQ 964
            |.|.||          ||.|...|     |:.|....:.        :.|..|.|    .:....
Human  3757 SSASDDYIVQTPMSTPEEIYPPYN-----ITVIGPYSIF--------VAWIPPGI----LIPEIP 3804

  Fly   965 LRYQVLLCDSGKQCKYKSLYQGEAYECIVQDLQPGQDYLVRLQVHYQKLTGTVSDPTEFRTPPCE 1029
            :.|.|||.|........|:  |.....::::|.|...|.:|:|.......| ||.....:||...
Human  3805 VEYNVLLNDGSVTPLAFSV--GHHQSTLLENLTPFTQYEIRIQACQNGSCG-VSSRMFVKTPEAA 3866

  Fly  1030 PDQPPPPKLVSRTKNSINLRWAAP-AANGASIQHY-------------LLEYDEGRMPGQPQKFV 1080
            |.....|.|.:.....|.::|..| ..||..|.::             |..:.||.:     :|:
Human  3867 PMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGAL-----EFM 3926

  Fly  1081 ELAKIKAKHYVIGKLQPTTVYSFRLAAVNEAGQSPYSPVASYSTSGNPPPVPKP-PQLLASSSSS 1144
            :..         ..|:|.|:|.:|:.|.|..|.  ...:.|.:.:...||...| |...|:|:.|
Human  3927 DEG---------DTLRPFTLYEYRVRACNSKGS--VESLWSLTQTLEAPPQDFPAPWAQATSAHS 3980

  Fly  1145 LKLGW-----------------ERRAQDGDFLLQLQDAETGHGFLNTYKGTELQTECLQLRRASS 1192
            :.|.|                 :.|..|..|     ::.|.|.|  |.|||..|.....|...::
Human  3981 VLLNWTKPESPNGIISHYRVVYQERPDDPTF-----NSPTVHAF--TVKGTSHQAHLYGLEPFTT 4038

  Fly  1193 YQFRLRSENEAG--FSPWSPEVSYRTLAERPGRPGKPHAKGKIHGTQFKARWDAPSDSGGAEILC 1255
            |:..:.:.|.||  .|||:   ..:||...|........:.|.:|.....:|..|..:.|. |..
Human  4039 YRIGVVAANHAGEILSPWT---LIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGV-IKT 4099

  Fly  1256 YH------LELSAAGPAFERIYSGAETEAMCERLQPGTTYAL----------------------- 1291
            |:      ||           |||...:.:..||.|.|.|.|                       
Human  4100 YNIFSDGFLE-----------YSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEA 4153

  Fly  1292 --------------------------------------RACCEGPA------------------- 1299
                                                  |.|.||.|                   
Human  4154 PPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNT 4218

  Fly  1300 ----------GQSP----------YSDIGH-------VTTEAVPPSAPPPPHCS-DPPSPYAALL 1336
                      |..|          ::..||       |.|...||....||..| ...:|...|:
Human  4219 ERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLI 4283

  Fly  1337 KLRPPEYNGGAPILEFEAQMRRLEQVQPPQLVYRGKQTYFVAQDLTPGGMYETQVRAINRIGAGS 1401
            ...|||.:.|  |:: ..:::|.|.:.|  ..:......:..::|.|...|...::|... |..|
Human  4284 SWIPPEQSNG--IIQ-SYRLQRNEMLYP--FSFDPVTFNYTDEELLPFSTYSYALQACTS-GGCS 4342

  Fly  1402 WSQWMRFTAAAAAPGVPEELRVLVKSATHLGVSWQPPLQENGAPVTSYTLKSASQERKEDDSEEE 1466
            .|:....|...|||.......:...|||.:.|.|.||..:|| .:|.|.::.        |::|.
Human  4343 TSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNG-KITKYLVRY--------DNKES 4398

  Fly  1467 VKEPPSSEFHNCYQGPQTCAELRNLSPYTRYHFRIQASNSAG-TGNSSDVISVCTPAAVPGAPQM 1530
            :            .|...|..:.:|.||::|:|.:.|..:.| |.:.|.  |..|..|:|.....
Human  4399 L------------AGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSK--SAWTMEALPENMDS 4449

  Fly  1531 QGYEFTAQE-VTLNWTQPAAHGSPICSYNIEYGERTIATPDACTRYTVSGLMPETGYKFRVQAVN 1594
            ...:.|..| :.:.|..|......|.||.:. .:.||......|||....|.|...|.:.|.|.|
Human  4450 PTLQVTGSESIEITWKPPRNPNGQIRSYELR-RDGTIVYTGLETRYRDFTLTPGVEYSYTVTASN 4513

  Fly  1595 AIGAGAFSAYAKLTTQPAPPA---PPRLECSGAGHNYIKLKWGE--NGNGKVVNSNPSGNGGDFT 1654
            :.| |..|...|..|.|:.|:   ||:|:..|.  ..|.:.|..  ..||.::|         :|
Human  4514 SQG-GILSPLVKDRTSPSAPSGMEPPKLQARGP--QEILVNWDPPVRTNGDIIN---------YT 4566

  Fly  1655 KYFVEMYVARAK--QFQAVYSGTNCMCK-VHKLQERSSYTFRIYAHTDRAGDGDYSEEFVFETSA 1716
            .:..|::....|  .....::....... |::|:....|..||.|.|..   |..|.::.|..:.
Human  4567 LFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTL---GCASSDWTFIQTP 4628

  Fly  1717 TLPANIKPPRVVQEGSVCLMELPGQLGMQLTLEWQHSKNSFNDRVEYELQYAVLGAAELEGESLS 1781
            .:...::||..::     :...||.....::|.|...... |.:|.|         .||....::
Human  4629 EIAPLMQPPPHLE-----VQMAPGGFQPTVSLLWTGPLQP-NGKVLY---------YELYRRQIA 4678

  Fly  1782 PKGRSSSSSGSSNGAPINLPNHDYRQLYRGPETKFTIDNLAAGTCYQFRVCPVRIAAGGELLY-- 1844
            .:.|.|:        |:        .:|.|..|.|....|...|.|:::|..|..|......:  
Human  4679 TQPRKSN--------PV--------LIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTW 4727

  Fly  1845 --GQPSSPLRYQVPSELDPSSATCHHHLHGSTATPAMASSQRSSRKLSAGNGSTNGLHMRSVSAS 1907
              ..|:.|...:.|:            .|..::|.|:.:       :|| .|..||:    ||..
Human  4728 CRTGPAPPEGLRAPT------------FHVISSTQAVVN-------ISA-PGKPNGI----VSLY 4768

  Fly  1908 AISGASGVGADPVAIGRL--QQELSG----------------FNACADPQHHHHHHHHHHHQPCG 1954
            .:..:|..||:.|....:  ||.|.|                ||.|:  :........|...|.|
Human  4769 RLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCS--KGPTAELRTHPAPPSG 4831

  Fly  1955 GGVGGAGGISGATDSHH----QHQHHMHHSHHM--HHAHHP--------------HTGMGGSSSN 1999
            ......|.::..|.|..    ...:.:.||:.:  |.|..|              :||:|..:| 
Human  4832 LSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKAS- 4895

  Fly  2000 SSSSTAAAISSSLAQAGGLR-------RIVC--KVTSLYSNRRRLSDQQKAVCIVVSFLVGTFLV 2055
                           .|||:       |:|.  :|.|..|.....:.|::.......|.|.:.|.
Human  4896 ---------------LGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDSNLS 4945

  Fly  2056 AMLVN 2060
            .:.||
Human  4946 VVCVN 4950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mtgoNP_001137829.1 FN3 <937..>1125 CDD:442628 42/201 (21%)
FN3 1037..1124 CDD:238020 20/100 (20%)
FN3 <1149..1216 CDD:238020 20/85 (24%)
FN3 1221..1312 CDD:238020 29/203 (14%)
FN3 1334..1409 CDD:238020 16/74 (22%)
FN3 <1380..>1609 CDD:442628 61/230 (27%)
FN3 1619..1714 CDD:238020 20/99 (20%)
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:470680
EGF_Lam 517..565 CDD:238012
EGF_Lam 574..639 CDD:238012
Laminin_EGF 641..691 CDD:395007
EGF_Lam 694..733 CDD:214543
Laminin_EGF 747..795 CDD:395007
EGF_Lam 794..844 CDD:238012
EGF_Lam 847..897 CDD:214543
EGF_Lam 900..948 CDD:238012
EGF_Lam 950..1000 CDD:238012
EGF_Lam 1001..>1037 CDD:238012
fn3 1058..1132 CDD:394996
FN3 1103..>1469 CDD:442628
FN3 1242..1357 CDD:238020
LamG 1519..1678 CDD:238058
LamG 1716..1868 CDD:238058
FN3 <1865..>2127 CDD:442628
FN3 1956..2051 CDD:238020
FN3 2252..2722 CDD:442628
FN3 2533..2619 CDD:238020
FN3 <2685..3074 CDD:442628
FN3 <3450..3846 CDD:442628 41/172 (24%)
FN3 3866..3960 CDD:238020 22/109 (20%)
FN3 <3927..>4190 CDD:442628 58/295 (20%)
FN3 3964..4057 CDD:238020 27/99 (27%)
fn3 4161..4247 CDD:394996 7/85 (8%)
FN3 4268..4351 CDD:238020 20/88 (23%)
FN3 4342..>4765 CDD:442628 116/516 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541 7/22 (32%)
FN3 4826..4927 CDD:238020 22/116 (19%)
PDZ-binding 5200..5202
Blue background indicates that the domain is not in the aligned region.

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