Protein Alignment mtgo and Fndc3b

DIOPT Version :10

• Sequence 1: NP_001137829.1
• Gene: mtgo / 34987
• FlyBaseID: FBgn0259735
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_775274.2
• Gene: Fndc3b / 72007
• MGIID: 1919257
• Length: 1207
• Species: Mus musculus
• Alignment Length: 1291
• Identity: 395/1291 - (30%)
• Similarity: 559/1291 - (43%)
• Gaps: 247/1291 - (19%)

  Fly   623 VPVQVPQYVN-ENGTLTHVMLSPQQYQ----QLHPGQGHLHPAPFISANGTSHFYTPVAGYPGPG 682
            :|:::|..:| |...:.|::......|    |::||:.....|    .:||.......|..|...
Mouse    11 IPLELPPLLNGEVAMMPHLVNGEAAQQVILVQVNPGETFTIRA----EDGTLQCIQGPAEVPMMS 71

  Fly   683 PAGNGPPHYHLPP----------------PPPPQQQQQQPPQQPQQQAPQGPPPPQQQQQQQQQV 731
            |.|:.|| .|:||                ...||..:..||..|...:|....||.
Mouse    72 PNGSIPP-IHVPPGYISQVIEDSTGVRRVVVTPQSPECYPPSYPSAMSPTHHLPPY--------- 126

  Fly   732 APPAVQGAPSTGSVGAAQGAPATATATHTHAHSHSHSHAHSHT----------------HPQPHA 780
                                     .||     |.|...:|||                .||||.
Mouse   127 -------------------------LTH-----HPHFIQNSHTAYYPPVTVPGDMPPQFFPQPHL 161

  Fly   781 HSPHSPSPPN-YRDERSQRQHNKLLRKLEKQRESNPPHSPSPRRANELNGHNNNNIPPGVPLPGH 844
                   ||. |.:......:........:.:.|.|||.....|  :::..|..|.||..
Mouse   162 -------PPTIYSEPEIIPLYGMSSYVTREDQYSKPPHKKLKDR--QIDRQNRLNSPPST----- 212

  Fly   845 LNNHHHAVNHQGRRLPQQHQGQAHQVAQQQQSQARNGNPQHPQRAGSSVGGASSVG-------TS 902
            :..:..|..:.|       .|:.|.                   .|||.||....|       |.
Mouse   213 IYKNSCATVYNG-------YGKGHS-------------------GGSSGGGGGGSGGGPGIKKTE 251

  Fly   903 EDGEDNSSLAGDDEEEYHRENSIIEQI-SAIEKPEVIDVTSRAAKIIWESPAIANTVTVDMR--- 963
            .....:...:..|.:||..|...::.| |.||||:|.::.:||..:.|..|       |.:.
Mouse   252 RRARSSPKSSDSDLQEYELEVKRVQDILSGIEKPQVSNIQARAVVLSWAPP-------VGLSCGP 309

  Fly   964 ------QLRYQVLLCDSGKQCKYKSLYQGEAYECIVQDLQPGQDYLVRLQVHYQKLTGTVSDPTE 1022
                  ...|:|.|.|.|:..|||.:|.||..||.::||:|..||.||:...|..:.|:.|:|..
Mouse   310 HGGLSFPYSYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAVYNSVKGSCSEPVS 374

  Fly  1023 FRTPPCEPDQPPPPKLVSRTKNSINLRWAAPAANGASIQHYLLEYDEG-RMPGQPQKFVELAKIK 1086
            |.|..|.|:.|.||||..|:|:|:.|:|.||..||:.|..||||:||| |..|..|.|..    .
Mouse   375 FTTHSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITSYLLEWDEGKRNSGFRQCFFG----S 435

  Fly  1087 AKHYVIGKLQPTTVYSFRLAAVNEAGQSPYSPVASYSTSGNPPPVPKPPQLLASSSSSLKLGWER 1151
            .||..:.||.|...|:|||||.|:.|.|.||......|.||.|.:|..|:|:.:..:.:.|.|.|
Mouse   436 QKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPLAPRLVRAGVTWITLQWSR 500

  Fly  1152 RAQDG-------DFLLQLQDAETGHGFLNTYKGTELQTECLQLRRASSYQFRLRSENEAGFSPWS 1209
              .:|       .:.|.:|:.|....|...|.|.:|......|:|::.|:|||.:.|..|.|..|
Mouse   501 --PEGCSPEEVITYTLDIQEDENDSHFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNMEGKSCPS 563

  Fly  1210 PEVSYRTLAERPGRPGKPHAKGKIHGTQFKARWDAPSDSGGAEILCYHLEL----SAAGPAFERI 1270
            ..:...|..:|||.|.:|..||.:....|..:||||.|:||:|||.|.||:    |.|| .:|..
Mouse   564 EVLVCTTSPDRPGPPTRPLIKGPVTSHGFSVKWDAPKDNGGSEILKYLLEITDGTSEAG-QWEVA 627

  Fly  1271 YSGAETEAMCERLQPGTTYALRACCEGPAGQSPYSDIGHVTTEAVPPSAPPPPHCSDPPSPYAAL 1335
            |||:.||.:...|:|||.|.|||||....|.|..|:...|.|.::.|....||.....|......
Mouse   628 YSGSATEYVFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSLAPGQCRPPRVLGRPKHKGVH 692

  Fly  1336 LKLRPPEYNGGAPILEFEAQMRRLEQVQPPQLVYRGKQTYFVAQDLTPGGMYETQVRAINRIGAG 1400
            |:...|....|..:.|:..:|...|.|...  ||.|.:......:|.||.:|..:|||:|..|.|
Mouse   693 LEWDVPASESGCEVSEYSVEMTEPENVASE--VYHGPELECTVGNLLPGTVYRFRVRALNDGGYG 755

  Fly  1401 SWSQWMRFTAAAAAPGVPEELRVLVKSATHLGVSWQPPLQENGAPVTSYTLKSASQERKEDDSEE 1465
            .:|.....|.||..||.....||.......:.|.|:.|... ||.::.|.|     |..||:...
Mouse   756 PYSDVSEITTAAGPPGQCRAPRVSFTPDGCVLVGWESPASP-GADISEYRL-----EWGEDEQSL 814

  Fly  1466 EVKEPPSSEFHNCYQGPQTCAELRNLSPYTRYHFRIQASNSAGTGNSSDVISVCTPAAVPG---- 1526
            |:          .|.||.||.|:|:|.|..:|..|:||.|.||.|..|:::...|||:.|.
Mouse   815 EL----------VYHGPDTCFEMRDLLPAAQYCCRLQAFNPAGAGPYSELVHCQTPASAPDPVST 869

  Fly  1527 ------APQMQGYEFTAQEVTLNWTQPAAHGSPICSYNIEYGERTIATPDACTRYTVSGLMPETG 1585
                  .|.....:..:..:.|||.:|..:||.|.:|||:.|:..| |....|.:.:..|:|||.
Mouse   870 LCVLEEEPPSAHPDSPSVCLVLNWEEPCNNGSEILAYNIDLGDSCI-TVGNTTTHVMKNLLPETT 933

  Fly  1586 YKFRVQAVNAIGAGAFSAYAKLTTQPAPPAPPRLECSGAGHNYIKLKWGENGNGKVVNSNPSGNG 1650
            |:.|:||:|.||.|.||.:.|..|:|.||:||||||:.:|...:|||||:: |.|      :...
Mouse   934 YRIRIQAINEIGVGPFSQFIKAKTRPLPPSPPRLECAASGPQSLKLKWGDS-NSK------THAA 991

  Fly  1651 GDFTKYFVEMYVARAKQFQAVYSGTNCMCKVHKLQERSSYTFRIYAHTDRAGDGDYSEEFVFETS 1715
            ||.. |.::: ..|.|:|.::|.|.:...||.:|.|.:.|:|||.|.:: ||:|.|||.:.|.|:
Mouse   992 GDMV-YTLQL-EDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAMSE-AGEGPYSETYTFSTT 1053

  Fly  1716 ATLPANIKPPRVVQ-EGSVCLMELPGQLGMQLTLEWQHSKNSFNDRVEYELQYAVLGAAELEGES 1779
            .::|..:|.|||.| ||:.|            .:.|:.......|.|.|.||..|
Mouse  1054 KSVPPTLKAPRVTQLEGNSC------------EIFWETVPPMRGDPVSYVLQVLV---------- 1096

  Fly  1780 LSPKGRSSSSSGSSNGAPINLPNHDYRQLYRGPETKFTIDNLAAGTCYQFRVCPVR 1835
                ||.|                :|:|:|:|.|..|.|..|.:.|.|:||||..|
Mouse  1097 ----GRDS----------------EYKQVYKGEEATFQISGLQSNTDYRFRVCACR 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtgo	NP_001137829.1	FN3	<937..>1125	CDD:442628	76/197 (39%)
		FN3	1037..1124	CDD:238020	39/87 (45%)
		FN3	<1149..1216	CDD:238020	20/73 (27%)
		FN3	1221..1312	CDD:238020	43/94 (46%)
		FN3	1334..1409	CDD:238020	21/74 (28%)
		FN3	<1380..>1609	CDD:442628	81/238 (34%)
		FN3	1619..1714	CDD:238020	35/94 (37%)
Fndc3b	NP_775274.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..213		9/35 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	230..265		7/53 (13%)
		FN3	283..377	CDD:238020	34/100 (34%)
		FN3	382..473	CDD:238020	43/94 (46%)
		FN3	481..570	CDD:238020	24/90 (27%)
		FN3	<540..>799	CDD:442628	92/262 (35%)
		FN3	<832..>1066	CDD:442628	91/244 (37%)
		FN3	<1017..>1149	CDD:442628	51/159 (32%)