Protein Alignment mtgo and Fndc3a

DIOPT Version :10

• Sequence 1: NP_001137829.1
• Gene: mtgo / 34987
• FlyBaseID: FBgn0259735
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_997519.2
• Gene: Fndc3a / 319448
• MGIID: 1196463
• Length: 1198
• Species: Mus musculus
• Alignment Length: 1342
• Identity: 404/1342 - (30%)
• Similarity: 599/1342 - (44%)
• Gaps: 280/1342 - (20%)

  Fly   606 GPA-VQMVSQNRPPPPMPVPV-QVPQYVNENGTLTHVMLSPQQYQQLHPGQGH--LHPAPFISAN 666
            ||| |.|:|.|...||:.||. ..||.:.:|| :..|::.||. .:.||| ||  :|.:|
Mouse    59 GPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNG-VRRVVVVPQS-PEFHPG-GHTVIHRSP----- 115

  Fly   667 GTSHFYTPVAGYPGPGPAGNGPPHYHLPPPPPPQQQQQQPPQQPQQQAPQGPPPPQQQQQQQQQV 731
                 :.|:.|:              :|.|                  ...||||:...
Mouse   116 -----HPPLPGF--------------IPVP------------------TMMPPPPRHMY------ 137

  Fly   732 APPAVQGAPSTGSVGAAQGAPATATATHTHAHSHSHSHAHSHTHPQPHAHSPHSPSPPNYRDERS 796
                   :|.||:     |..||         .:...:..|..:....|||.|..|  |:|||||
Mouse   138 -------SPVTGA-----GDMAT---------QYMPQYQSSQVYADVDAHSTHGRS--NFRDERS 179

  Fly   797 QRQHNKLLRKL------EKQRESNPPHSPSPRRANELNGHNNNNIPPGVPLPGHLNNHHHAVNHQ 855
            .:.:.:|.:||      :|.:.|:||  |||::.                 |..::.|:..:..|
Mouse   180 SKTYERLQKKLKDRQGTQKDKMSSPP--PSPQKC-----------------PSPISEHNGLIKGQ 225

  Fly   856 GRRLPQQHQGQAHQVAQQQQSQARNGNPQHPQRAGSSVGGASSVGTSEDGEDNSSLAGDDE-EEY 919
                                               ::.||.:....:..|...|....|.| ||.
Mouse   226 -----------------------------------NASGGNTGSARNRSGRGRSCTQVDPEMEEK 255

  Fly   920 HRENSIIEQ-ISAIEKPEVIDVTSRAAKIIWESPA------IANTVTVDMRQLRYQVLLCDSGKQ 977
            ..|....|. :|.|.||...|:.:|...:.|..|:      :..|...::  ..|:||:..:||:
Mouse   256 DEETKAFEAFLSNIVKPVASDIQARTVLLTWSPPSSFINGEVNETAVPEL--FNYEVLVSSTGKE 318

  Fly   978 CKYKSLYQGEAYECIVQDLQPGQDYLVRLQVHYQKLTGTVSDPTEFRTPPCEPDQPPPPKLVSRT 1042
            .||:|:|.||.....:.||:|..||..::|.....:.|..|:...|.|..||||.|..|::.:||
Mouse   319 GKYRSVYIGEETSVTLNDLKPATDYHAKVQAESNSIKGIPSEAESFTTLSCEPDPPNAPRIANRT 383

  Fly  1043 KNSINLRWAAPAANGASIQHYLLEYDEGRMPGQPQKFVELAKIKAKHYVIGKLQPTTVYSFRLAA 1107
            |||:.|:|.||:.||:.||.::||:|||:..|:   |.:......|.:.|.||.|.....|||:|
Mouse   384 KNSLTLQWKAPSDNGSKIQSFILEWDEGKGNGE---FCQCYMGSQKQFKITKLSPAMGCKFRLSA 445

  Fly  1108 VNEAGQSPYSPVASYSTSGNPPPVPKPPQLLASSSSSLKLGWER----RAQDG-DFLLQLQDAET 1167
            .|:.|.|.:|....|.|||..|.||..|.|..:..:.|.|.|.:    .:.:| .::|::::..:
Mouse   446 KNDYGVSDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSGTPSDEGISYILEMEEETS 510

  Fly  1168 GHGFLNTYKGTELQTECLQLRRASSYQFRLRSENEAGFSPWSPEVSYRTLAERPGRPGKPHAKGK 1232
            |:||...|.|.:|......|||::.|:|::.:.|..|.|..|..|.:.|..::||.|.||..|||
Mouse   511 GYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFSTCPDKPGVPVKPSVKGK 575

  Fly  1233 IHGTQFKARWDAPSDSGGAEILCYHLELS--AAGPAFERIYSGAETEAMCERLQPGTTYALRACC 1295
            ||...||..||.|.|:|||.|..|.:|::  :.|..::.||||...|.:|:||.||..|.||..|
Mouse   576 IHSHGFKITWDPPKDNGGAPINKYVVEMAEGSNGNKWDMIYSGTTREHLCDRLTPGCYYRLRVYC 640

  Fly  1296 EGPAGQSPYSDIGHVTTEAVPPSAPPPPHCSDPPSPYAALLKLRPPEYNGGAPILEFEAQMRRLE 1360
            ....|||..|:...|.|.||||....||.....|......|:..||:.:||:||..:..:|...:
Mouse   641 ISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPQVDGGSPISCYAVEMTPAD 705

  Fly  1361 QVQPPQLVYRGKQTYFVAQDLTPGGMYETQVRAINRIGAGSWSQWMRFTAAAAAPGVPEELR--- 1422
            :.:|.. ||:|.:.......|.||..|..::||.||||.|.:|:....|   .|||.|::.|
Mouse   706 KDEPRD-VYQGSEVECTVGSLLPGKTYSFRLRAANRIGFGPFSEKYDIT---TAPGPPDQCRPPQ 766

  Fly  1423 VLVKSATHLGVSWQPPLQENGAPVTSYTLKSASQERKEDDSEEEVKEPPSSEFHNCYQGPQTCAE 1487
            |..:|||...|:|:.|| .||..||.|.|:....|               .....||.||....|
Mouse   767 VTCRSATCAQVNWEIPL-SNGTDVTEYRLEWGGVE---------------GSMQMCYCGPGLSCE 815

  Fly  1488 LRNLSPYTRYHFRIQASNSAGTGNSSDVISVCTPAAVPGAPQMQGYEFTAQEVT----------- 1541
            |:.|||.|.|:.|:||.:..|.|..|:|::..||.:||....      ..||::
Mouse   816 LKGLSPATTYYCRVQAMSVVGAGPFSEVVACVTPPSVPAIVT------CLQEISDDDIEYPHYSP 874

  Fly  1542 -----LNWTQPAAHGSPICSYNIEYGERTIATPDACTRYTVSGLMPETGYKFRVQAVNAIGAGAF 1601
                 ::|.:|..|||.|.:|:|:.|::...|....|.|.:..|.|:|.|:.|:||:|::|||.|
Mouse   875 STCLAISWKEPYDHGSEILAYSIDLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLGAGPF 939

  Fly  1602 SAYAKLTTQPAPPAPPRLECSGAGHNYIKLKWGENGNGKVVNSNPSGNGGDFTKYFVEMYVARAK 1666
            |...||.|:|.||.||||||....|..:|||||| |..|.:::       |..:|.::| ..|..
Mouse   940 SHTIKLKTKPLPPDPPRLECVAFNHQNLKLKWGE-GTPKTLST-------DAVQYHLQM-EDRNG 995

  Fly  1667 QFQAVYSGTNCMCKVHKLQERSSYTFRIYAHTDRAGDGDYSEEFVFETSATLPANIKPPRVVQ-E 1730
            :|.::|.|.....||.:|.|.:||.|.|.| .:.||:|..|:|:||.|..:|||.:|.|::.: .
Mouse   996 RFVSLYRGPCHTYKVQRLSESTSYKFCIQA-CNEAGEGPLSQEYVFTTPKSLPAALKAPKIEKIN 1059

  Fly  1731 GSVCLMELPGQLGMQLTLEWQHSKNSFNDRVEYELQYAVLGAAELEGESLSPKGRSSSSSGSSNG 1795
            ..:|            .:.|::.:....|.|.|.||..|              |:.|
Mouse  1060 DHIC------------EITWEYLQPMKGDPVIYNLQVMV--------------GKDS-------- 1090

  Fly  1796 APINLPNHDYRQLYRGPETKFTIDNLAAGTCYQFRVCPVRIAAGGELLYGQPSSPLRYQVPSELD 1860
                    :::|:|:||:|.|...:|.....|:||||.:|...                     |
Mouse  1091 --------EFKQIYKGPDTSFRYSSLQLNCEYRFRVCAIRQCQ---------------------D 1126

  Fly  1861 PSSATCHHHLHGSTATPAMASSQRSSRKLSAGNGSTNGLHMR 1902
            |   |.|..|.|..:|.....|||:....|:...|.:....|
Mouse  1127 P---TGHQDLVGPYSTTVFFISQRTEPPASSNKDSVDSARTR 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtgo	NP_001137829.1	FN3	<937..>1125	CDD:442628	66/193 (34%)
		FN3	1037..1124	CDD:238020	34/86 (40%)
		FN3	<1149..1216	CDD:238020	19/71 (27%)
		FN3	1221..1312	CDD:238020	42/92 (46%)
		FN3	1334..1409	CDD:238020	24/74 (32%)
		FN3	<1380..>1609	CDD:442628	84/247 (34%)
		FN3	1619..1714	CDD:238020	35/94 (37%)
Fndc3a	NP_997519.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	188..257		20/122 (16%)
		FN3	<274..>620	CDD:442628	123/350 (35%)
		FN3	678..754	CDD:238020	25/79 (32%)
		FN3	756..848	CDD:238020	37/107 (35%)
		FN3	<818..>1096	CDD:442628	104/335 (31%)