Protein Alignment mtgo and FNDC3A

DIOPT Version :10

• Sequence 1: NP_001137829.1
• Gene: mtgo / 34987
• FlyBaseID: FBgn0259735
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: NP_001073141.1
• Gene: FNDC3A / 22862
• HGNCID: 20296
• Length: 1198
• Species: Homo sapiens
• Alignment Length: 1321
• Identity: 402/1321 - (30%)
• Similarity: 606/1321 - (45%)
• Gaps: 250/1321 - (18%)

  Fly   606 GPA-VQMVSQNRPPPPMPVPV-QVPQYVNENGTLTHVMLSPQQYQQLHPGQGH--LHPAPFISAN 666
            ||| |.|:|.|...||:.||. ..||.:.:|| :..|::.||. .:.||| .|  ||.:|
Human    59 GPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNG-VRRVVVVPQA-PEFHPG-SHTVLHRSP----- 115

  Fly   667 GTSHFYTPVAGYPGPGPAGNGPPHYHLPPPPPPQQQQQQPPQQPQQQAPQGPPPPQQQQQQQQQV 731
                 :.|:.|:              :|.|                  ...||||:...
Human   116 -----HPPLPGF--------------IPVP------------------TMMPPPPRHMY------ 137

  Fly   732 APPAVQGAPSTGSVGAAQGAPATATATHTHAHSHSHSHAHSHTHPQPHAHSPHSPSPPNYRDERS 796
                   :|.||:     |...|         .:...:..|..:....|||.|..|  |:|||||
Human   138 -------SPVTGA-----GDMTT---------QYMPQYQSSQVYGDVDAHSTHGRS--NFRDERS 179

  Fly   797 QRQHNKLLRKL------EKQRESNPPHSPS--PRRANELNGHNNNNIPPGVPLPGHLNNHHHAVN 853
            .:.:.:|.:||      :|.:.|:||.||.  |...||.||.....|..|:
Human   180 SKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGI-------------- 230

  Fly   854 HQGRRLPQQHQGQAHQVAQQQQSQARNGNPQHPQRAGSSVGGASSVGTSEDGEDNSSLAGDDEEE 918
                     :.|.|                  ..::|...|     ||..|.|         .||
Human   231 ---------NTGSA------------------KIKSGKGKG-----GTQVDTE---------IEE 254

  Fly   919 YHRENSIIEQ-ISAIEKPEVIDVTSRAAKIIWESPAIANTVTVDMRQL----RYQVLLCDSGKQC 978
            ...|....|. :|.|.||...|:.:|...:.|..|:.......|...:    .|:||:..:||..
Human   255 KDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDG 319

  Fly   979 KYKSLYQGEAYECIVQDLQPGQDYLVRLQVHYQKLTGTVSDPTEFRTPPCEPDQPPPPKLVSRTK 1043
            ||||:|.||.....:.||:|..||..::|..|..:.||.|:...|.|..||||.|.||::.:|||
Human   320 KYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTK 384

  Fly  1044 NSINLRWAAPAANGASIQHYLLEYDEGRMPGQPQKFVELAKIKAKHYVIGKLQPTTVYSFRLAAV 1108
            ||:.|:|.||:.||:.||:::||:|||:..|:   |.:......|.:.|.||.|.....|||:|.
Human   385 NSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGE---FCQCYMGSQKQFKITKLSPAMGCKFRLSAR 446

  Fly  1109 NEAGQSPYSPVASYSTSGNPPPVPKPPQLLASSSSSLKLGWER----RAQDG-DFLLQLQDAETG 1168
            |:.|.|.:|....|.|||..|.:|..|.|..:..:.|.|.|.:    .:.:| .::|::::..:|
Human   447 NDYGTSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEETSG 511

  Fly  1169 HGFLNTYKGTELQTECLQLRRASSYQFRLRSENEAGFSPWSPEVSYRTLAERPGRPGKPHAKGKI 1233
            :||...|.|.:|......|||::.|:|::.:.|..|.|..|..|.:.|..::||.|.||..||||
Human   512 YGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGIPVKPSVKGKI 576

  Fly  1234 HGTQFKARWDAPSDSGGAEILCYHLELS--AAGPAFERIYSGAETEAMCERLQPGTTYALRACCE 1296
            |...||..||.|.|:|||.|..|.:|::  :.|..:|.|||||..|.:|:||.||..|.||..|.
Human   577 HSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCI 641

  Fly  1297 GPAGQSPYSDIGHVTTEAVPPSAPPPPHCSDPPSPYAALLKLRPPEYNGGAPILEFEAQMRRLEQ 1361
            ...|||..|:...|.|.||||....||.....|......|:..||..:||:||..:..:|..:|:
Human   642 SDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEK 706

  Fly  1362 VQPPQLVYRGKQTYFVAQDLTPGGMYETQVRAINRIGAGSWSQWMRFTAAAAAPGVPEELR---V 1423
            .:|.: ||:|.:.......|.||..|..::||.|::|.|.:|:....|   .|||.|::.:   |
Human   707 DEPRE-VYQGSEVECTVSSLLPGKTYSFRLRAANKMGFGPFSEKCDIT---TAPGPPDQCKPPQV 767

  Fly  1424 LVKSATHLGVSWQPPLQENGAPVTSYTLKSASQERKEDDSEEEVKEPPSSEFHNCYQGPQTCAEL 1488
            ..:|||...|:|:.|| .||..||.|.|:....|               .....||.||....|:
Human   768 TCRSATCAQVNWEVPL-SNGTDVTEYRLEWGGVE---------------GSMQICYCGPGLSYEI 816

  Fly  1489 RNLSPYTRYHFRIQASNSAGTGNSSDVISVCTPAAVPG-APQMQGYEFTAQEV-----------T 1541
            :.|||.|.|:.|:||.:..|.|..|:|::..||.:||| ...:|  |.:..|:           .
Human   817 KGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIVTCLQ--EISDDEIENPHYSPSTCLA 879

  Fly  1542 LNWTQPAAHGSPICSYNIEYGERTIATPDACTRYTVSGLMPETGYKFRVQAVNAIGAGAFSAYAK 1606
            ::|.:|..|||.|.:|:|::|::...|....|.|.::.|.|:|.|:.|:||:|::|||.||...|
Human   880 ISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFSHMIK 944

  Fly  1607 LTTQPAPPAPPRLECSGAGHNYIKLKWGENGNGKVVNSNPSGNGGDFTKYFVEMYVARAKQFQAV 1671
            |.|:|.||.||||||....|..:|||||| |..|.:::       |..:|.::|.....: |.::
Human   945 LKTKPLPPDPPRLECVAFSHQNLKLKWGE-GTPKTLST-------DSIQYHLQMEDKNGR-FVSL 1000

  Fly  1672 YSGTNCMCKVHKLQERSSYTFRIYAHTDRAGDGDYSEEFVFETSATLPANIKPPRVVQ-EGSVCL 1735
            |.|.....||.:|.|.:||.|.|.| .:.||:|..|:|::|.|..::||.:|.|::.: ...:|
Human  1001 YRGPCHTYKVQRLNESTSYKFCIQA-CNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHIC- 1063

  Fly  1736 MELPGQLGMQLTLEWQHSKNSFNDRVEYELQYAVLGAAELEGESLSPKGRSSSSSGSSNGAPINL 1800
                       .:.|:..:....|.|.|.||..:              |:.|
Human  1064 -----------EITWECLQPMKGDPVIYSLQVML--------------GKDS------------- 1090

  Fly  1801 PNHDYRQLYRGPETKFTIDNLAAGTCYQFRVCPVR---IAAGGELLYGQPSSPLRYQVPSELDPS 1862
               :::|:|:||::.|...:|.....|:||||.:|   .:.|.:.|.|..|:.:.: :....:|.
Human  1091 ---EFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLF-ISQRTEPP 1151

  Fly  1863 SATCHHHLHGSTATPAMASSQ 1883
            ::|....:..:....|::..|
Human  1152 ASTNRDTVESTRTRRALSDEQ 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtgo	NP_001137829.1	FN3	<937..>1125	CDD:442628	70/191 (37%)
		FN3	1037..1124	CDD:238020	34/86 (40%)
		FN3	<1149..1216	CDD:238020	19/71 (27%)
		FN3	1221..1312	CDD:238020	44/92 (48%)
		FN3	1334..1409	CDD:238020	23/74 (31%)
		FN3	<1380..>1609	CDD:442628	82/243 (34%)
		FN3	1619..1714	CDD:238020	33/94 (35%)
FNDC3A	NP_001073141.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..221		24/62 (39%)
		FN3	267..366	CDD:238020	32/98 (33%)
		FN3	371..462	CDD:238020	39/93 (42%)
		FN3	<466..855	CDD:442628	142/408 (35%)
		FN3	<811..>1070	CDD:442628	95/282 (34%)