Protein Alignment mtgo and fndc3a

DIOPT Version :10

• Sequence 1: NP_001137829.1
• Gene: mtgo / 34987
• FlyBaseID: FBgn0259735
• Length: 2064
• Species: Drosophila melanogaster
• Sequence 2: XP_073780331.1
• Gene: fndc3a / 100333097
• ZFINID: ZDB-GENE-030131-7015
• Length: 1249
• Species: Danio rerio
• Alignment Length: 1429
• Identity: 415/1429 - (29%)
• Similarity: 617/1429 - (43%)
• Gaps: 315/1429 - (22%)

  Fly   540 PSPVTNVNGNIAQAAAAAASAPRLLLQL---DAATVQQQQQQQHQQQQQHQQQQQQQIVAAGKRS 601
            |.|...|||:..|..        :|:|:   :|.|:|:...|                      .
Zfish    29 PHPANIVNGDGPQQV--------ILVQVNPGEAFTIQRDDGQ----------------------F 63

  Fly   602 KVYRGPA-VQMVSQNRPPPPMPVPV-QVPQYVNENGTLTHVMLSPQQYQQLHPG-QGHLHPAPFI 663
            :...||| |.|:|.|...|.:.||. .|.|.:.||| :..|::.||  .:.||| ...||.||
Zfish    64 QCITGPAQVPMMSPNGSVPQIYVPPGYVQQIIEENG-VRRVLVLPQ--TEFHPGAHSPLHHAP-- 123

  Fly   664 SANGTSHFYTPVAGYPGPGPAGNGPPHYHL----PPP----PPPQQQQQQPPQQPQQQAPQGPPP 720
                          :|        |||.||    |.|    |||...
Zfish   124 --------------HP--------PPHTHLQAFIPHPHIMHPPPHLY------------------ 148

  Fly   721 PQQQQQQQQQVAPPAVQGAPSTGSVGAAQGAPATATATHTHAHSHSHSHAHSHTHPQPHAHSPHS 785
                                 :|..|.....|...:..|.   :|...::...||||      |.
Zfish   149 ---------------------SGLAGGTGDIPQYISQYHP---AHPAIYSEQETHPQ------HG 183

  Fly   786 PSPPNYRDERSQRQHNKLLRKLEKQR------------ESNPPHSPSPRRANELNGHNNNNIPPG 838
            .:...:||||:.:.:.:|.:||:.::            :.:||  |||::        |...||
Zfish   184 RAAFAHRDERTCKTYERLQKKLKDKQGVGGGGGGLALSKDSPP--PSPQK--------NLGTPP- 237

  Fly   839 VPLPGHLNNHHHAVNHQGRRLPQQHQGQAHQVAQQQQSQARNGNPQHPQRAGSSVGGASSVGTSE 903
            ....|.|.|     ..:|:          ..|.|.|.|....       |.|.|......|   |
Zfish   238 AGAAGELQN-----GLEGK----------SNVDQAQPSNTIT-------RLGKSPVRKKEV---E 277

  Fly   904 DGEDNSSLAGDDEEEYHRENSIIEQISAIEKPEVIDVTSRAAKIIWESPAIANTVTVDMRQ---- 964
            .||       .|||    ..::.|:::::.||.|.::.:|.|.:.|.||  :.|...|..:
Zfish   278 PGE-------LDEE----AKALQERLNSMCKPVVTNIQARGASLTWVSP--SRTEGDDEPKEGED 329

  Fly   965 ------LRYQVLLCDSGKQCKYKSLYQGEAYECIVQDLQPGQDYLVRLQVHYQKLTGTVSDPTEF 1023
                  ..|:|.:..:||..||||.|.|......:|||:|..||.||:|.....|.|..|:...|
Zfish   330 EPVEPNFTYEVSISYNGKDGKYKSAYSGVELSATLQDLRPATDYHVRVQATCNCLQGVPSEAVSF 394

  Fly  1024 RTPPCEPDQPPPPKLVSRTKNSINLRWAAPAANGASIQHYLLEYDEGRMPGQPQKFVELAKIKAK 1088
            .|..||||.|.||:.:|.||:|:.|:|.||..||:.||:|:|.:|||:  |....||:......|
Zfish   395 TTLSCEPDTPSPPRKLSGTKSSLVLQWKAPCDNGSKIQNYILHWDEGK--GTDATFVQCYYGPYK 457

  Fly  1089 HYVIGKLQPTTVYSFRLAAVNEAGQSPYSPVASYSTSGNPPPVPKPPQLLASSSSSLKLGWERRA 1153
            .|.:.||...:.|||||||.|:.|.|.:|.|.:..||.:.|..|..|:|:.|..:.|.:.|.|.|
Zfish   458 QYRLTKLSTASRYSFRLAAKNDMGVSEFSEVVNIMTSCSVPAPPLSPELVQSGVTWLCIRWHRPA 522

  Fly  1154 -----QDGDFLLQLQDAETGHGFLNTYKGTELQTECLQLRRASSYQFRLRSENEAGFSPWSPEVS 1213
                 .|..::|::::..:|:||..:|.|.||......|.|:::|:||:.:.|..|.|..|....
Zfish   523 GSPKEDDTGYVLEMEEQGSGYGFQASYDGEELSHTVRNLHRSTTYRFRVVAYNTEGKSNPSAVSE 587

  Fly  1214 YRTLAERPGRPGKPHAKGKIHGTQFKARWDAPSDSGGAEILCYHLELS--AAGPAFERIYSGAET 1276
            :.|..:||..|.:...|||.|.|.|:..||.|.||||:::..|.:|||  .:|.::.:.|||:..
Zfish   588 FTTAPDRPSCPCRLAVKGKPHPTSFRLTWDPPKDSGGSDVTKYVVELSEGLSGSSWSQAYSGSAL 652

  Fly  1277 EAMCERLQPGTTYALRACCEGPAGQSPYSDIGHVTTEAVPPSAPPPPHCSDPPSPYAALLKLRPP 1341
            |.:|:.|.||::|..|..|....|:||.::...|.|..|||....||.....|......|:..||
Zfish   653 ECVCDGLSPGSSYQARVHCISAGGESPLTEALQVQTPPVPPGPCQPPRVVGKPKAREVQLRWAPP 717

  Fly  1342 EYNGGAPILEFEAQMRRLEQVQPPQLVYRGKQTYFVAQDLTPGGMYETQVRAINRIGAGSWSQWM 1406
            ..:||:.:..:..:| ...||...:.||:|.:.......|.||..|..::||.|:.|.|.:|:..
Zfish   718 LVDGGSSVSLYNLEM-FAPQVDEAREVYQGSELDCTVPSLLPGRTYGFRIRAANKAGYGPFSERS 781

  Fly  1407 RFTAAAAAPGVPEELR---VLVKSATHLGVSWQPPLQENGAPVTSYTLKSASQERKEDDSEEEVK 1468
            ..|   ..||.||..|   :..||.|...|||:.|: .|||.|:.|.|:..:.|
Zfish   782 EVT---TGPGAPEACRPPHITCKSPTCAVVSWEAPV-SNGAVVSEYRLEWGAAE----------- 831

  Fly  1469 EPPSSEFHNCYQGPQTCAELRNLSPYTRYHFRIQASNSAGTGNSSDVISVCTPAAVPGA------ 1527
                .....||.|...|.|:|.|.|...|..|:||.|:||.|..|:::...||.:||..
Zfish   832 ----GSMQVCYSGAALCHEMRGLLPANNYFCRVQAVNAAGAGPFSELMFCQTPCSVPAMISSVHA 892

  Fly  1528 ---PQMQGYEFTAQE-----------------------VTLNWTQPAAHGSPICSYNIEYGERTI 1566
               .:|:..|.||:.                       :.|.|..|..|||.|.||.|:.||:..
Zfish   893 LRDSEMKIQERTAERGEEEEEDEEEDEESAMLYSPSTCLGLRWEAPCDHGSQITSYLIDLGEKQP 957

  Fly  1567 ATPDACTRYTVSGLMPETGYKFRVQAVNAIGAGAFSAYAKLTTQPAPPAPPRLECSGAGHNYIKL 1631
            ......|:|.:..|.|:|.|:.|:||:|::|.|.||...||.|:|.||.||||||:.:.|..::|
Zfish   958 ILTGPVTQYIIQNLQPDTTYRIRIQALNSLGTGPFSHTFKLKTKPLPPLPPRLECTASSHQTLRL 1022

  Fly  1632 KWGENGNGKVVNSNPSGNGGDFTKYFVEMYVARAKQFQAVYSGTNCMCKVHKLQERSSYTFRIYA 1696
            |||: |..|   :.|:    |..:|.::|.....: |.::|.|.....||.:|.|.:||.|||.|
Zfish  1023 KWGD-GPAK---AQPT----DSLQYHLQMEDKNGR-FISLYKGPCHTHKVQRLNESTSYAFRIQA 1078

  Fly  1697 HTDRAGDGDYSEEFVFETSATLPANIKPPRVVQEGSVCLMELPGQLGMQLTLEWQHSKNSFNDRV 1761
            ..: ||:|.:|..:.|.|..:.||.:|.|||.:....|            .:.|:.......|.:
Zfish  1079 FNE-AGEGPFSSVYTFTTPRSPPAPLKAPRVERVDESC------------EVSWETLPPMKGDPI 1130

  Fly  1762 EYELQYAVLGAAELEGESLSPKGRSSSSSGSSNGAPINLPNHDYRQLYRGPETKFTIDNLAAGTC 1826
            .|.||.       ::|                        |.|::|:|:|..:.|.:.||::...
Zfish  1131 IYCLQC-------MQG------------------------NSDFKQIYKGSSSSFQLPNLSSSMD 1164

  Fly  1827 YQFRVCPVRIAAGGELLYGQPSSPLRYQVPSELDPSSATCHHHLHGSTATPAMASSQRSSRKLS 1890
            |:||||.:|.......:.|..||.: ..:|:.:|....|      ||:.:.. |.:|:..|.|:
Zfish  1165 YRFRVCAIRQCQDAPEIIGSYSSTV-ILLPARVDGPGPT------GSSGSKT-AENQKPKRSLT 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mtgo	NP_001137829.1	FN3	<937..>1125	CDD:442628	75/197 (38%)
		FN3	1037..1124	CDD:238020	36/86 (42%)
		FN3	<1149..1216	CDD:238020	21/71 (30%)
		FN3	1221..1312	CDD:238020	35/92 (38%)
		FN3	1334..1409	CDD:238020	21/74 (28%)
		FN3	<1380..>1609	CDD:442628	83/263 (32%)
		FN3	1619..1714	CDD:238020	32/94 (34%)
fndc3a	XP_073780331.1	None