DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tpr2 and DNAJC3

DIOPT Version :9

Sequence 1:	NP_001260501.1	Gene:	Tpr2 / 34984	FlyBaseID:	FBgn0032586	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	XP_011519406.1	Gene:	DNAJC3 / 5611	HGNCID:	9439	Length:	533	Species:	Homo sapiens

Alignment Length:	503	Identity:	132/503 - (26%)
Similarity:	222/503 - (44%)	Gaps:	54/503 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EEKKKLGNDQYKAQNYQNALKLYTDAISLCPDSAAYYGNRAACYMMLLNYNSALTDARHAIRIDP 114
            |:..:||.....|....:||..:..|:...||:...|..||..::.:....:||.|....|::..
Human    38 EKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKM 102

  Fly   115 GFEKAYVRVAKCCLALGDIIGTEQAVK---------------MVNELNSL----------STAVA 154
            .|..|.::.....|..|.:...|...|               ::::|..|          |....
Human   103 DFTAARLQRGHLLLKQGKLDEAEDDFKKVVFPVPSLLGLQRSLLDDLYLLFWFFLMKKLKSNPSE 167

  Fly   155 AEQTAAQ-------KLRQLEATIQANYDTKSYRNVVFYLDSALKLAPACLKYRLLKAECLAFLGR 212
            .|:..||       ::::|.:.....:.:..|...:.:||..|::.....:.|.|:|||....|.
Human   168 NEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELRAECFIKEGE 232

  Fly   213 CDEALDIAVSVMKLDTTSADAIYVRGLCLYYTDNLDKGILHFERALTLDPDHYKSKQMRSKCKQL 277
            ..:|:....:..||...:.:|.|......|...:.:..:......|.||.||.:......:.|:|
Human   233 PRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKL 297

  Fly   278 KEMKENGNMLFKSGRYREAHVIYTDALK----IDEHNKDINSKLLYNRALVNTRIGNLREAVADC 338
            .::.|:...|.:.|||.:|...|...:|    |.|:......::.:..:.....:    ||:..|
Human   298 NKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPV----EAIRVC 358

  Fly   339 NRVLELNSQYLKALLLRARCYNDLEKFEESVADYETALQ-LEKTPEIKRMLREAKFALKKSKRKD 402
            :.||::....:.||..||..|...|.::|::.|||||.: .|...:|:..|.:|:..||:|:::|
Human   359 SEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQEHNENDQQIREGLEKAQRLLKQSQKRD 423

  Fly   403 YYKILGIGRNASDDEIKKAYRKKALVHHPDRHANSSAEERKEEELKFKEVGEAYAILSDAHKKSR 467
            ||||||:.|||...||.|||||.||..|||...|.  ||:|:.|.||.::..|..:|||...:.:
Human   424 YYKILGVKRNAKKQEIIKAYRKLALQWHPDNFQNE--EEKKKAEKKFIDIAAAKEVLSDPEMRKK 486

  Fly   468 YDSGQD-IEEQEQADFDPNQMFRT------FFQFNGGGRNNSSFNFEF 508
            :|.|:| ::.:.|.....|...|:      |..|:.||    .|.|:|
Human   487 FDDGEDPLDAESQQGGGGNPFHRSWNSWQGFNPFSSGG----PFRFKF 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tpr2	NP_001260501.1	TPR_11	49..114	CDD:290150	16/63 (25%)
		TPR repeat	49..77	CDD:276809	7/26 (27%)
		TPR repeat	82..112	CDD:276809	7/29 (24%)
		TPR_11	201..262	CDD:290150	13/60 (22%)
		TPR repeat	201..225	CDD:276809	6/23 (26%)
		TPR_1	231..264	CDD:278916	6/32 (19%)
		TPR repeat	231..259	CDD:276809	3/27 (11%)
		TPR_11	278..345	CDD:290150	15/70 (21%)
		TPR repeat	310..344	CDD:276809	5/33 (15%)
		TPR_11	314..380	CDD:290150	17/66 (26%)
		TPR repeat	349..377	CDD:276809	12/27 (44%)
		DnaJ	401..>503	CDD:223560	43/108 (40%)
		DnaJ	402..469	CDD:278647	33/66 (50%)
DNAJC3	XP_011519406.1	TPR_11	36..100	CDD:290150	16/61 (26%)
		TPR repeat	37..65	CDD:276809	7/26 (27%)
		TPR repeat	70..100	CDD:276809	7/29 (24%)
		TPR_11	73..132	CDD:290150	13/58 (22%)
		TPR repeat	105..132	CDD:276809	5/26 (19%)
		TPR_11	182..246	CDD:290150	12/63 (19%)
		TPR repeat	186..211	CDD:276809	4/24 (17%)
		TPR_11	216..281	CDD:290150	13/64 (20%)
		TPR repeat	216..246	CDD:276809	7/29 (24%)
		TPR repeat	251..279	CDD:276809	3/27 (11%)
		TPR repeat	285..309	CDD:276809	4/23 (17%)
		TPR repeat	330..364	CDD:276809	7/37 (19%)
		TPR_19	347..411	CDD:291240	20/67 (30%)
		TPR_1	369..402	CDD:278916	13/32 (41%)
		TPR repeat	369..397	CDD:276809	12/27 (44%)
		TPR repeat	403..426	CDD:276809	8/22 (36%)
		DnaJ	421..>527	CDD:223560	43/111 (39%)
		DnaJ	423..488	CDD:278647	33/66 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53711
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R325
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950