DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tpr2 and UNC45A

DIOPT Version :10

Sequence 1:NP_523584.1 Gene:Tpr2 / 34984 FlyBaseID:FBgn0032586 Length:508 Species:Drosophila melanogaster
Sequence 2:NP_061141.2 Gene:UNC45A / 55898 HGNCID:30594 Length:944 Species:Homo sapiens


Alignment Length:534 Identity:117/534 - (21%)
Similarity:206/534 - (38%) Gaps:156/534 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 PKDA---ATIAEEKKKLGNDQYKAQNYQNALKLYTDAISL--CP-DSAAYYGNRAACYMMLLNYN 100
            |:.|   |:..|:.:|.||:.:|..:|..||..||.|:.|  .| |.|..:.|||||::.|.:|:
Human    11 PRPATPGASSVEQLRKEGNELFKCGDYGGALAAYTQALGLDATPQDQAVLHRNRAACHLKLEDYD 75

  Fly   101 SALTDARHAIRIDPGFEKAYVRVAKCCLALGDIIGTEQAVKMVNELNSLSTAVAAEQTA------ 159
            .|.|:|..||..|.|..||..|.::....||.:   :|||..:....||.......|.|      
Human    76 KAETEASKAIEKDGGDVKALYRRSQALEKLGRL---DQAVLDLQRCVSLEPKNKVFQEALRNIGG 137

  Fly   160 --AQKLRQLEAT-------IQANYD---------TKSYRNVV-----------FYLDSALKLAPA 195
              .:|:|.:.:|       .|...|         .|:.:|:|           .:..:.::|...
Human   138 QIQEKVRYMSSTDAKVEQMFQILLDPEEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQR 202

  Fly   196 CL---KYRLLKAECLAFLGRCDE-------ALDI-----AVSVMKLDTTSADAIYVRGLCLYY-- 243
            .|   :..|:.|.....:|.|.|       .|.|     .||::.:::.:........|.:.:  
Human   203 LLDMGETDLMLAALRTLVGICSEHQSRTVATLSILGTRRVVSILGVESQAVSLAACHLLQVMFDA 267

  Fly   244 -TDNLDKGILHFERALTLDPDHYKSKQMRSKCKQLKEMKENGNMLFK----SGRYREAHVIYTDA 303
             .:.:.||....|.|:.:||           .::||.:..|...|..    ||:.|:      :|
Human   268 LKEGVKKGFRGKEGAIIVDP-----------ARELKVLISNLLDLLTEVGVSGQGRD------NA 315

  Fly   304 LKI------DEHNKDINSKL---LYNRALVNTRI----GNLREAVADCNRVLELNSQYLKALLLR 355
            |.:      .:..||.|:.|   :.::.|  .:|    |:|::...:.  .:..||: :.|.:|.
Human   316 LTLLIKAVPRKSLKDPNNSLTLWVIDQGL--KKILEVGGSLQDPPGEL--AVTANSR-MSASILL 375

  Fly   356 ARCYNDLEKFEESVADYETALQLEKTPEIKRMLREAKFALKKSKRKDYYKILGIGRNASDDEIKK 420
            ::.::||:      .|.|               ||....|.::..|.:::..|:.     .:::.
Human   376 SKLFDDLK------CDAE---------------RENFHRLCENYIKSWFEGQGLA-----GKLRA 414

  Fly   421 AYRKKALVHHPDRHANSS--------------AEERKEEELKFKE-----VGEA----------Y 456
            ......|:..|....|.:              |.|::||:|...|     .|:|          .
Human   415 IQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQEEEQLVAVEALIHAAGKAKRASFITANGV 479

  Fly   457 AILSDAHKKSRYDS 470
            ::|.|.:|.|..||
Human   480 SLLKDLYKCSEKDS 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tpr2NP_523584.1 TPR repeat 49..77 CDD:276809 11/27 (41%)
TPR 55..>258 CDD:440225 62/258 (24%)
TPR repeat 82..112 CDD:276809 13/29 (45%)
TPR 190..419 CDD:440225 48/263 (18%)
TPR repeat 201..225 CDD:276809 9/35 (26%)
TPR repeat 231..259 CDD:276809 5/30 (17%)
TPR repeat 310..344 CDD:276809 8/40 (20%)
TPR repeat 349..377 CDD:276809 6/27 (22%)
DnaJ_bact 402..>503 CDD:274090 18/98 (18%)
UNC45ANP_061141.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 3/9 (33%)
TPR 1 21..54 12/32 (38%)
TPR repeat 21..49 CDD:276809 11/27 (41%)
NlpI <28..>125 CDD:443815 37/99 (37%)
TPR repeat 57..87 CDD:276809 13/29 (45%)
TPR 2 58..91 14/32 (44%)
TPR 3 92..125 10/35 (29%)
TPR repeat 92..120 CDD:276809 8/30 (27%)
UNC45-central 363..505 CDD:432011 30/158 (19%)
armadillo repeat 768..803 CDD:293788
armadillo repeat 806..842 CDD:293788
Blue background indicates that the domain is not in the aligned region.

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