Protein Alignment Tpr2 and Unc45a

DIOPT Version :10

• Sequence 1: NP_523584.1
• Gene: Tpr2 / 34984
• FlyBaseID: FBgn0032586
• Length: 508
• Species: Drosophila melanogaster
• Sequence 2: NP_598713.2
• Gene: Unc45a / 101869
• MGIID: 2142246
• Length: 944
• Species: Mus musculus
• Alignment Length: 522
• Identity: 113/522 - (21%)
• Similarity: 209/522 - (40%)
• Gaps: 134/522 - (25%)

  Fly    42 PKD-AATIAEEKKKLGNDQYKAQNYQNALKLYTDAISL--CP-DSAAYYGNRAACYMMLLNYNSA 102
            |.| .|:.||:.:|.||:.:|..:|:.||..||.|:||  .| |.|..:.|||||::.|.:|:.|
Mouse    13 PSDPGASSAEQLRKEGNELFKCGDYEGALTAYTQALSLGATPQDQAILHRNRAACHLKLEDYSKA 77

  Fly   103 LTDARHAIRIDPGFEKAYVRVAKCCLALGDIIGTEQAVKMVNELNSLSTAVAAEQTA-------- 159
            .::|..||..|.|..||..|.::....||.:   :|||..:....||.......|.:
Mouse    78 ESEASKAIEKDGGDVKALYRRSQALEKLGRL---DQAVLDLKRCVSLEPKNKVFQESLRNIGGQI 139

  Fly   160 AQKLRQLEAT-------IQANYD---------TKSYRNVV-----------FYLDSALKLAPACL 197
            .:|:|.:.:|       .|...|         .|:.:|:|           .:..:.::|....|
Mouse   140 QEKVRYMSSTDAKVEQMFQILLDPKEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLL 204

  Fly   198 ---KYRLLKAECLAFLGRCDE-------ALDI-----AVSVMKLDTTSADAIYVRGLCLYY---T 244
               :..|:.|.....:|.|.|       .|.:     .||::.::..:........|.:.:   .
Mouse   205 DTEETDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSILGVENQAVSLAACHLLQVIFDALK 269

  Fly   245 DNLDKGILHFERALTLDPDHYKSKQMRSKCKQLKEMKENGNMLFKSGRYREAHVIYTDALKIDEH 309
            :.:.||....|.|:.:||    :::::.....|.|:.....:   ||:.|:..:.....:...:.
Mouse   270 EGVKKGFRGKEGAIIVDP----ARELKVLINSLLELLTEVGV---SGQGRDNALTLLIKMVPRKS 327

  Fly   310 NKDINSKL---LYNRALVNTRI----GNLREAVADCNRVLELNSQYLKALLLRARCYNDLEKFEE 367
            .||.|:.|   :.::.|  .:|    |:|::|..:.  .:..||: :.|.:|.::.::||:
Mouse   328 PKDPNNSLTLWVIDQGL--KKILEVGGSLQDAAGEL--TVTANSR-MSASILLSKLFDDLK---- 383

  Fly   368 SVADYETALQLEKTPEIKRMLREAKFALKKSKRKDYYKILGIGRNASDDEIKKAYRKKALVHHPD 432
              .|.|               ||....|.::..:::::..|:.     .:::.......|:..|.
Mouse   384 --CDAE---------------RENFHRLCENYIRNWFEGHGLA-----GKLRAIQTVSCLLQGPC 426

  Fly   433 RHANSS--------------AEERKEEELKFKE-----VGEA----------YAILSDAHKKSRY 468
            ...|.:              |.||:||:|...|     .|:|          .::|.|.:|.|..
Mouse   427 DAGNRALELSGVMESVIALCASEREEEQLVAVEALIHAAGKAKRASFITANGVSLLKDLYKGSER 491

  Fly   469 DS 470
            ||
Mouse   492 DS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tpr2	NP_523584.1	TPR repeat	49..77	CDD:276809	12/27 (44%)
		TPR	55..>258	CDD:440225	60/258 (23%)
		TPR repeat	82..112	CDD:276809	12/29 (41%)
		TPR	190..419	CDD:440225	43/253 (17%)
		TPR repeat	201..225	CDD:276809	8/35 (23%)
		TPR repeat	231..259	CDD:276809	5/30 (17%)
		TPR repeat	310..344	CDD:276809	9/40 (23%)
		TPR repeat	349..377	CDD:276809	6/27 (22%)
		DnaJ_bact	402..>503	CDD:274090	19/98 (19%)
Unc45a	NP_598713.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		5/11 (45%)
		NlpI	<21..>125	CDD:443815	40/106 (38%)
		TPR 1	21..54		14/32 (44%)
		TPR repeat	21..49	CDD:276809	12/27 (44%)
		TPR repeat	57..87	CDD:276809	12/29 (41%)
		TPR 2	58..91		13/32 (41%)
		TPR 3	92..125		10/35 (29%)
		TPR repeat	92..120	CDD:276809	8/30 (27%)
		UNC45-central	361..505	CDD:432011	30/162 (19%)