DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tpr2 and Dnajc3

DIOPT Version :9

Sequence 1:	NP_001260501.1	Gene:	Tpr2 / 34984	FlyBaseID:	FBgn0032586	Length:	508	Species:	Drosophila melanogaster
Sequence 2:	NP_032955.2	Gene:	Dnajc3 / 100037258	MGIID:	107373	Length:	504	Species:	Mus musculus

Alignment Length:	479	Identity:	131/479 - (27%)
Similarity:	217/479 - (45%)	Gaps:	35/479 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 EEKKKLGNDQYKAQNYQNALKLYTDAISLCPDSAAYYGNRAACYMMLLNYNSALTDARHAIRIDP 114
            |:..:||.....|....:||..:..|:...||:...|..||..::.:....:||.|....|.:..
Mouse    38 EKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIALKM 102

  Fly   115 GFEKAYVRVAKCCLALGDIIGTEQAVKMV--------NELNSLSTAVAAEQTAAQKLRQLEATIQ 171
            .|..|.::.....|..|.:...|...|.|        .|..:.|..|.|::....:.:.|:|
Mouse   103 DFTAARLQRGHLLLKQGKLDEAEDDFKKVLKSNPSEQEEKEAESQLVKADEMQRLRSQALDA--- 164

  Fly   172 ANYDTKSYRNVVFYLDSALKLAPACLKYRLLKAECLAFLGRCDEALDIAVSVMKLDTTSADAIYV 236
              :|...|...:.:||..|::.....:.|.|:|||....|...:|:....:..||.:.:.:|.|.
Mouse   165 --FDGADYTAAITFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKSDNTEAFYK 227

  Fly   237 RGLCLYYTDNLDKGILHFERALTLDPDHYKSKQMRSKCKQLKEMKENGNMLFKSGRYREAHVIYT 301
            .....|...:.:..:......|.||.||.:......:.|:|.::.|:...|.:.|||.:|...|.
Mouse   228 ISTLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDATSKYE 292

  Fly   302 DALK----IDEHNKDINSKLLYNRALVNTRIGNLREAVADCNRVLELNSQYLKALLLRARCYNDL 362
            ..:|    :.|:......::.:..:.....:    ||:..|:.||::....:.||..||..|...
Mouse   293 SVMKTEPSVAEYTVRSKERICHCFSKDEKPV----EAIRICSEVLQMEPDNVNALKDRAEAYLIE 353

  Fly   363 EKFEESVADYETALQ-LEKTPEIKRMLREAKFALKKSKRKDYYKILGIGRNASDDEIKKAYRKKA 426
            |.::|::.|||.|.: .|...:|:..|.:|:..||:|:::|||||||:.|||...||.|||||.|
Mouse   354 EMYDEAIQDYEAAQEHNENDQQIREGLEKAQRLLKQSQKRDYYKILGVKRNAKKQEIIKAYRKLA 418

  Fly   427 LVHHPDRHANSSAEERKEEELKFKEVGEAYAILSDAHKKSRYDSGQD-IEEQEQADFDPNQMFRT 490
            |..|||...|.  ||:|:.|.||.::..|..:|||...:.::|.|:| ::.:.|.....|...|:
Mouse   419 LQWHPDNFQNE--EEKKKAEKKFIDIAAAKEVLSDPEMRKKFDDGEDPLDAESQQGGGGNPFHRS 481

  Fly   491 ------FFQFNGGGRNNSSFNFEF 508
                  |..|:.||    .|.|:|
Mouse   482 WNSWQGFNPFSSGG----PFRFKF 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tpr2	NP_001260501.1	TPR_11	49..114	CDD:290150	16/63 (25%)
		TPR repeat	49..77	CDD:276809	7/26 (27%)
		TPR repeat	82..112	CDD:276809	7/29 (24%)
		TPR_11	201..262	CDD:290150	13/60 (22%)
		TPR repeat	201..225	CDD:276809	6/23 (26%)
		TPR_1	231..264	CDD:278916	6/32 (19%)
		TPR repeat	231..259	CDD:276809	3/27 (11%)
		TPR_11	278..345	CDD:290150	14/70 (20%)
		TPR repeat	310..344	CDD:276809	5/33 (15%)
		TPR_11	314..380	CDD:290150	16/66 (24%)
		TPR repeat	349..377	CDD:276809	11/27 (41%)
		DnaJ	401..>503	CDD:223560	43/108 (40%)
		DnaJ	402..469	CDD:278647	33/66 (50%)
Dnajc3	NP_032955.2	TPR_11	36..100	CDD:290150	16/61 (26%)
		TPR 1	37..70		8/31 (26%)
		TPR repeat	37..65	CDD:276809	7/26 (27%)
		TPR repeat	70..100	CDD:276809	7/29 (24%)
		TPR 2	72..104		7/31 (23%)
		TPR_11	73..136	CDD:290150	14/62 (23%)
		TPR 3	105..138		6/32 (19%)
		TPR repeat	105..133	CDD:276809	6/27 (22%)
		TPR_1	107..137	CDD:278916	6/29 (21%)
		TPR_11	153..217	CDD:290150	14/68 (21%)
		TPR 4	154..187		7/37 (19%)
		TPR repeat	157..182	CDD:276809	6/29 (21%)
		TPR_11	187..252	CDD:290150	13/64 (20%)
		TPR repeat	187..217	CDD:276809	7/29 (24%)
		TPR 5	188..221		9/32 (28%)
		TPR 6	222..255		6/32 (19%)
		TPR repeat	222..250	CDD:276809	3/27 (11%)
		TPR repeat	256..280	CDD:276809	4/23 (17%)
		TPR 7	268..301		9/32 (28%)
		TPR repeat	301..335	CDD:276809	6/37 (16%)
		TPR 8	306..339		5/36 (14%)
		TPR_19	318..382	CDD:291240	19/67 (28%)
		TPR 9	340..373		12/32 (38%)
		TPR_1	340..373	CDD:278916	12/32 (38%)
		TPR repeat	340..368	CDD:276809	11/27 (41%)
		TPR repeat	374..397	CDD:276809	8/22 (36%)
		Flexible linker. /evidence=ECO:0000250	375..393		6/17 (35%)
		DnaJ	392..>498	CDD:223560	43/111 (39%)
		DnaJ	394..459	CDD:278647	33/66 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..481		6/29 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53711
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R325
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950