Protein Alignment Nepl8 and ECE2

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001093590.1
• Gene: ECE2 / 9718
• HGNCID: 13275
• Length: 811
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 162/739 - (21%)
• Similarity: 291/739 - (39%)
• Gaps: 182/739 - (24%)

  Fly     3 IICLLLVPLVA--------ASSNT-------RLLNGILSHVDKEANPCENYYNHACGQYNMRH-I 51
            :..|||..|||        .|.:|       |:...||..:|:..:|||::|..:||.:..|: :
Human   116 LAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPL 180

  Fly    52 DD------TFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSS-VDGKVLRYYLSCRGAPRNM 109
            .|      ||..:...     ||.::|.:  ||.::    ||.|| .:.|..|:||||....|..
Human   181 PDGRSRWNTFNSLWDQ-----NQAILKHL--LENTT----FNSSSEAEQKTQRFYLSCLQVERIE 234

  Fly   110 DSLSQYLKVISP---GEGLTWPQFIPDGSSWPQENF-KWLKALAHLHRYGLTNVFFNLEVVSNPR 170
            :..:|.|:.:..   |..:|.|        |.|:|| :.|||:|..:|   ...||.:.:.::.:
Human   235 ELGAQPLRDLIEKIGGWNITGP--------WDQDNFMEVLKAVAGTYR---ATPFFTVYISADSK 288

  Fly   171 NASEYMVELNTPTFGEESQLPNSFIEILSVLYIIKVPSSEIITL--------------------- 214
            :::..::::      ::|.|   |:.... .|:.:..:.:::|.
Human   289 SSNSNVIQV------DQSGL---FLPSRD-YYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTRE 343

  Fly   215 -ARKMRTLELLLKTMINPIDTLNN-----RYISIRDFQ-METGHNWQRFFEILIG----SSAAPE 268
             .:::..||:.|..:..|.|...:     ..:||.:.| :....:|..|...|:.    |.:.|
Human   344 QMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEP- 407

  Fly   269 LQVLVRNFRYFTALKELMDKQDARLVASYIM------------TRFAIF---LLDETMGGRES-- 316
              |:|....|...:.||:::.:..::.:|::            .||...   ||:...|.::|
Human   408 --VVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCV 470

  Fly   317 ---TECVSQVRRNMNLAANMLYKERFFEDST---FSANILEIKDIFEKLRHQFLLQVDQNHLELT 375
               ..|:|.....:..|...|:.:..|:..:   ....|.||:..||:...| |:.:|    |.|
Human   471 PRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQ-LVWMD----EKT 530

  Fly   376 ALQMKFFVRKAEAIEINVVNLP-------KTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFR 433
            ....|   .||:|| .:::..|       :.||:       |..  :...|..:.|..|.:..|.
Human   531 RQAAK---EKADAI-YDMIGFPDFILEPKELDDV-------YDG--YEISEDSFFQNMLNLYNFS 582

  Fly   434 TQKMLAQSSKGHSEEQNILTYRSQAAPLPPPQ------------PFFQLESEDVFKYSLMGYIMA 486
            .:.|..|..|..|.:|..:|.::..|...|.:            ||:.........:..:|.:|.
Human   583 AKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMG 647

  Fly   487 HHLISAFATEGITIGSDGNDQ---------SFRSHR--FEEAVSCLSRNSENID------ESMGD 534
            |.|..||..:|.....:||.:         :||:|.  .||..:....|.|.::      |::.|
Human   648 HELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIAD 712

  Fly   535 IAGLELAYFTY-AKMAKN--RNRLDFTHLPPEQIFFLNVGQFFC------GNSDMLV--QYKEDQ 588
            ..||:.||..| |.:.|:  ..:|....|...|:||:...|.:|      .:.:.||  .:...:
Human   713 NGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPAR 777

  Fly   589 VRLQRAIEGFEPFDKAFGCYRNKP 612
            .|:...:.....|.:.|||....|
Human   778 FRVLGTLSNSRDFLRHFGCPVGSP 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	150/695 (22%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..64
		M13	160..809	CDD:341056	150/695 (22%)