Protein Alignment Nepl8 and ECEL1

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_004817.2
• Gene: ECEL1 / 9427
• HGNCID: 3147
• Length: 775
• Species: Homo sapiens
• Alignment Length: 732
• Identity: 148/732 - (20%)
• Similarity: 270/732 - (36%)
• Gaps: 209/732 - (28%)

  Fly    24 ILSHVDKEANPCENYYNHACGQYNMRHI---DDTFFDIIQMLDHQVNQNLVKLMDELEMSSQLPD 85
            :.:::|...:||:::|:.|||.:..||.   |...:..|..:..|..:.|.:|   |......|.
Human   112 LAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRL---LARPGGGPG 173

  Fly    86 FNVSSVDGKVLRYYLSC-------RGAPRNMDSLSQYLKVISPGEGLTWPQFIPDGSSWPQENFK 143
               .:...||..::.||       |..||.|      |:||....|  |.  :......|....:
Human   174 ---GAAQRKVRAFFRSCLDMREIERLGPRPM------LEVIEDCGG--WD--LGGAEERPGVAAR 225

  Fly   144 WLKALAHLHR--YGLTNVF-----FNLEVVSNPRNASEYMVELNTPTFGEESQLPNSFIEILSVL 201
            |     .|:|  |....|:     |:|.|..:.||:|.|::.::.    :...||.      ..|
Human   226 W-----DLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQ----DGLTLPE------RTL 275

  Fly   202 YIIKVPSSEIITLARKM---RTLELLLKTMI--------------------------NPIDTLNN 237
            |:.:...||.|..|.::   |.|.||....:                          ..:.::.|
Human   276 YLAQDEDSEKILAAYRVFMERVLSLLGADAVEQKAQEILQVEQQLANITVSEHDDLRRDVSSMYN 340

  Fly   238 RYISIRDFQMETGH-NWQRFFEILIGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTR 301
            : :::...|..|.| .|:...:.:.....:.|.:|::....|...:.:|:.....|::.:|::.|
Human   341 K-VTLGQLQKITPHLRWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWR 404

  Fly   302 FAIFL--------------LDETMGGRESTE-----CVSQVRRNMNLAANMLYKERFFEDSTFSA 347
            ..:.|              |.:.|.|.:..:     |:.|..|:..:|...|:....|.    :|
Human   405 VVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFS----AA 465

  Fly   348 NILEIKDIFEKLRH---QFLLQVDQNHLELTA-----LQMKF-------FVRKAEAIEINVVNLP 397
            :..:::.:.|.:::   |.|.::|....|..|     ||...       |:.|.:|::
Human   466 SKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFLLKPDAVD------- 523

  Fly   398 KTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKMLAQSSKGHSEEQNILTYRSQAAPLP 462
                         ::.:|...|..|.:..|..::|..|    .|.|...:|.:..|:      |.
Human   524 -------------KEYEFEVHEKTYFKNILNSIRFSIQ----LSVKKIRQEVDKSTW------LL 565

  Fly   463 PPQP----FFQLESEDVF------------------KYSLMGYIMAHHLISAFATEGITIGSDGN 505
            |||.    :...:::.||                  .|..:|.|:.|.|...:...|......||
Human   566 PPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGN 630

  Fly   506 ------DQSFRSHRFEEAVSCLSRNSEN-------------IDESMGDIAGLELAYFTYAKMAKN 551
                  :.|:  .||.....|:.|..:|             :.|::.|:.||:|||..|.|..:.
Human   631 LLHWWTEASY--SRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLKLAYHAYQKWVRE 693

  Fly   552 RN------RLDFTHLPPEQIFFLNVGQFFC---GNSDMLVQYKEDQ-----VRLQRAIEGFEPFD 602
            ..      ||.:||   :|:||:...|.:|   .:..:.:|...|:     .|:..::..||.|.
Human   694 HGPEHPLPRLKYTH---DQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFG 755

  Fly   603 KAFGCYRNKPKH--EKC 617
            :||.|.::.|.:  .||
Human   756 RAFHCPKDSPMNPAHKC 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	147/724 (20%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	147/724 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910