Protein Alignment Nepl8 and Ece1

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_006239337.1
• Gene: Ece1 / 94204
• RGDID: 620293
• Length: 769
• Species: Rattus norvegicus
• Alignment Length: 731
• Identity: 153/731 - (20%)
• Similarity: 275/731 - (37%)
• Gaps: 179/731 - (24%)

  Fly    10 PLVAASSNTRLLNGILSHVDKEANPCENYYNHACGQY-NMRHIDD------TFFDIIQMLDHQVN 67
            |:....:...:.:.||:.:|...:||::::::|||.: ....:.|      ||.:   :.:|  |
  Rat    96 PVCLTEACVSVTSSILNSMDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSN---LWEH--N 155

  Fly    68 QNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPR----NMDSLSQYLKVISPGEGLTWP 128
            |.::|.:  ||.|:.    :.|..:.|...||.:|....|    ....|.:.::.:. |..:|.|
  Rat   156 QAIIKHL--LENSTA----SASEAEKKAQVYYRACMNETRIEELRAKPLMELIEKLG-GWNITGP 213

  Fly   129 QFIPDGSSWPQENFK-WLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVELNTPTFGEESQLPN 192
                    |.::||: .|:.:...:|   |:.||::.|.::.:|::..:::::....|    ||:
  Rat   214 --------WAKDNFQDTLQVVTAHYR---TSPFFSVYVSADSKNSNSNVIQVDQSGLG----LPS 263

  Fly   193 SFIEILSVLYIIKVPSSEIIT-LARKMRTLELLLKTMINPIDTLNNRYISIRDFQMETGH----- 251
                  ...|:.|..:.:::| ....|..|..||..  ...|::..:...|.||:....:
  Rat   264 ------RDYYLNKTENEKVLTGYLNYMVQLGKLLGG--GDEDSIRPQMQQILDFETALANITIPQ 320

  Fly   252 NWQRFFEILIGSSAAPELQ--------------------------VLVRNFRYFTALKELMDKQD 290
            ..:|..|::.....|.|||                          ::|.:..|...:..|::..|
  Rat   321 EKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYLRQVSTLINSTD 385

  Fly   291 ARLVASYIM---TRFAIFLLD-----------ETMGGREST------ECVSQVRRNMNLAAN-ML 334
            ..|:.:|:|   .|.....||           |.|.|.:.|      .|||....|:..|.. |.
  Rat   386 KCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMF 450

  Fly   335 YKERFFEDSTFSAN--ILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINVVNLP 397
            .|..|.|||...|:  |||||..||:              .|:.|:......:..|.|
  Rat   451 VKATFAEDSKNIASEIILEIKKAFEE--------------SLSTLKWMDEDTRRSAKE------- 494

  Fly   398 KTDDLRHFIGQYYQDLQFPTGELD------------YHQEHLKVLQFRTQKMLAQSSKGHSEEQN 450
            |.|.:.:.||  |.:......|||            |.:..::...|..:....|..|..:.:|.
  Rat   495 KADAIYNMIG--YPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQW 557

  Fly   451 ILTYRSQAAPLPPPQ------------PFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSD 503
            .:|.....|...|.:            ||:...|.:...:..:|.::.|.|..||..:|.....|
  Rat   558 SMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKD 622

  Fly   504 GNDQSFRSH----RFEEAVSCL-------SRNSENID------ESMGDIAGLELAYFTYAKMAKN 551
            ||.:.:..:    .|::...|:       |.|.|.::      |::.|..||:.||..|....|.
  Rat   623 GNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKK 687

  Fly   552 RNR---LDFTHLPPEQIFFLNVGQFFC------GNSDMLV--QYKEDQVRLQRAIEGFEPFDKAF 605
            ...   |....|...|:|||...|.:|      .:.:.|:  .:...:.|:..::...:.|.:.|
  Rat   688 NGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHF 752

  Fly   606 GCYRNKPKH--EKCRL 619
            .|....|.:  .||.:
  Rat   753 RCPLGSPMNPRHKCEV 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	148/706 (21%)
Ece1	XP_006239337.1	M13	118..767	CDD:341056	148/706 (21%)