Protein Alignment Nepl8 and MMEL1

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 727
• Identity: 158/727 - (21%)
• Similarity: 288/727 - (39%)
• Gaps: 180/727 - (24%)

  Fly    24 ILSHVDKEANPCENYYNHACGQYNMRH-IDDT-----FFDIIQMLDHQVNQNLVKLMDELEMSSQ 82
            ||.::|....||:::|..|||.:..|| |.:|     .||:              |.||||:..:
Human   101 ILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDV--------------LRDELEVILK 151

  Fly    83 LPDFNVSSVD----GKVLRYYLSCRG----APRNMDSLSQYLKVISPGEGLTWPQFIPDGSSWPQ 139
            ....|.::.|    .|....|.||..    ..|....|...|:|:               ..||.
Human   152 AVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVV---------------GGWPV 201

  Fly   140 ENFKWLKALA---HLHR-YGLTNVFFNLEVV------SNPRNASEYMVELNTPTFGEES------ 188
            ...:|.:.:.   .|.| ..|.|..||..|:      ::.:|:|.:::.::.||.|..|
Human   202 AMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFN 266

  Fly   189 -----QLPNSFIE-ILSVLYIIK----VPSSEIITLARKMRTLEL---LLKTMI-----NPIDTL 235
                 ::..:::: ::||..:::    :|....:.....::.|||   |.|..:     :.:..|
Human   267 GGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIAL 331

  Fly   236 NNRYISIRDFQME---TGHNWQRFFEILIGS---SAAPELQVLVRNFRYFTALKELMDKQDARLV 294
            .:| :.:.:.|.:   .|.||..|.:.::.|   ...|:.:|:|....|...|:.::|...||.:
Human   332 YHR-MGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTI 395

  Fly   295 ASYIMTRFAIFLL--------DETMGGRES-----------TECVSQVRRNMNLAANMLY-KERF 339
            .:|::.|..:..:        |..:..|::           .|||..|..||..|...|| :|.|
Human   396 QNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAF 460

  Fly   340 FEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINV---VNLPK--T 399
            ..||...     ::::.:|:|..|:..:|:  |.....:.|   :||:...:::   :..|.  .
Human   461 PGDSKSM-----VRELIDKVRTVFVETLDE--LGWMDEESK---KKAQEKAMSIREQIGHPDYIL 515

  Fly   400 DDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKML----------------AQSSKGHSEE 448
            :::...:.:.|.:|.|  .|..|.:..|:.|:...|:.|                |..:..:|..
Human   516 EEMNRRLDEEYSNLNF--SEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPN 578

  Fly   449 QNILTYRSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGND----QSF 509
            :|.:.:  .|..|.|  |||..|......:..:|.::.|.:...|...|.....:||.    .:|
Human   579 RNQIVF--PAGILQP--PFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNF 639

  Fly   510 RSHRFEEAVSCL----------SRNSENID------ESMGDIAGLELAYFTYAKMAKNRNR---- 554
            .:..|.|...|:          ..:.:|::      |::.|..|:..||..|.|......:
Human   640 STQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQL 704

  Fly   555 --LDFTHLPPEQIFFLNVGQFFCGN--SDMLVQ-YKED-----QVRLQRAIEGFEPFDKAFGCYR 609
              ||.||   ||:||:|..|.:||:  .:..:| .|.|     :.|:..:::....|...|.|.|
Human   705 PGLDLTH---EQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCAR 766

  Fly   610 NKPKH--EKCRL 619
            ..|.|  |:||:
Human   767 GTPMHPKERCRV 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	153/716 (21%)
MMEL1	NP_258428.2	M13	111..777	CDD:341056	153/714 (21%)