DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl8 and MMEL1

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	727	Identity:	158/727 - (21%)
Similarity:	288/727 - (39%)	Gaps:	180/727 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ILSHVDKEANPCENYYNHACGQYNMRH-IDDT-----FFDIIQMLDHQVNQNLVKLMDELEMSSQ 82
            ||.::|....||:::|..|||.:..|| |.:|     .||:              |.||||:..:
Human   101 ILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDV--------------LRDELEVILK 151

  Fly    83 LPDFNVSSVD----GKVLRYYLSCRG----APRNMDSLSQYLKVISPGEGLTWPQFIPDGSSWPQ 139
            ....|.::.|    .|....|.||..    ..|....|...|:|:               ..||.
Human   152 AVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVV---------------GGWPV 201

  Fly   140 ENFKWLKALA---HLHR-YGLTNVFFNLEVV------SNPRNASEYMVELNTPTFGEES------ 188
            ...:|.:.:.   .|.| ..|.|..||..|:      ::.:|:|.:::.::.||.|..|
Human   202 AMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFN 266

  Fly   189 -----QLPNSFIE-ILSVLYIIK----VPSSEIITLARKMRTLEL---LLKTMI-----NPIDTL 235
                 ::..:::: ::||..:::    :|....:.....::.|||   |.|..:     :.:..|
Human   267 GGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIAL 331

  Fly   236 NNRYISIRDFQME---TGHNWQRFFEILIGS---SAAPELQVLVRNFRYFTALKELMDKQDARLV 294
            .:| :.:.:.|.:   .|.||..|.:.::.|   ...|:.:|:|....|...|:.::|...||.:
Human   332 YHR-MGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTI 395

  Fly   295 ASYIMTRFAIFLL--------DETMGGRES-----------TECVSQVRRNMNLAANMLY-KERF 339
            .:|::.|..:..:        |..:..|::           .|||..|..||..|...|| :|.|
Human   396 QNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAF 460

  Fly   340 FEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINV---VNLPK--T 399
            ..||...     ::::.:|:|..|:..:|:  |.....:.|   :||:...:::   :..|.  .
Human   461 PGDSKSM-----VRELIDKVRTVFVETLDE--LGWMDEESK---KKAQEKAMSIREQIGHPDYIL 515

  Fly   400 DDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKML----------------AQSSKGHSEE 448
            :::...:.:.|.:|.|  .|..|.:..|:.|:...|:.|                |..:..:|..
Human   516 EEMNRRLDEEYSNLNF--SEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPN 578

  Fly   449 QNILTYRSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGND----QSF 509
            :|.:.:  .|..|.|  |||..|......:..:|.::.|.:...|...|.....:||.    .:|
Human   579 RNQIVF--PAGILQP--PFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNF 639

  Fly   510 RSHRFEEAVSCL----------SRNSENID------ESMGDIAGLELAYFTYAKMAKNRNR---- 554
            .:..|.|...|:          ..:.:|::      |::.|..|:..||..|.|......:
Human   640 STQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQL 704

  Fly   555 --LDFTHLPPEQIFFLNVGQFFCGN--SDMLVQ-YKED-----QVRLQRAIEGFEPFDKAFGCYR 609
              ||.||   ||:||:|..|.:||:  .:..:| .|.|     :.|:..:::....|...|.|.|
Human   705 PGLDLTH---EQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCAR 766

  Fly   610 NKPKH--EKCRL 619
            ..|.|  |:||:
Human   767 GTPMHPKERCRV 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	153/716 (21%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	157/726 (22%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	153/714 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910