DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl8 and ece1

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	740	Identity:	154/740 - (20%)
Similarity:	275/740 - (37%)	Gaps:	192/740 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ICLLLVPLVAASSNTRLLNGILSHVDKEANPCENYYNHACGQYNMRHI----DDTFFDIIQMLDH 64
            :| |..|.|:.:|      .:|..:|:..:||:::||.|||.:..::.    ...:.....:.:|
Zfish    80 LC-LSEPCVSVAS------AVLGSLDRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEH 137

  Fly    65 QVNQNLVK-LMDELEMSSQLPDFNVSSVDGKVLRYYLSCR--------GAPRNMDSLSQYLKVIS 120
              |..::| |::...|.|      :|..:.|...||.:|.        ||....|.::|     :
Zfish   138 --NMAVMKNLLENTSMKS------LSRAEQKAQWYYQACMNESKIEELGAKPLQDLINQ-----T 189

  Fly   121 PGEGLTWPQFIPDGSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVELNTPTFG 185
            .|.||..|        |.::||:  :.|..:.....|:.||.:.|.::.::::..:::::....|
Zfish   190 GGWGLKGP--------WEKDNFQ--EVLRIVSANFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLG 244

  Fly   186 EESQLP---------------NSFIEILSVLYIIKVPSSEIITLARKMRTLELLLKTMINPIDTL 235
                ||               |:::..|..|.::         |.....|.:.:::.:|....||
Zfish   245 ----LPSREYYLNKTANEKYLNAYLNFLVELGVL---------LGGSQDTSQKMMEEIIEFETTL 296

  Fly   236 NN-------------RYISIRDFQMET---GHNWQRFFEILIGSSAAP-ELQ----VLVRNFRYF 279
            .|             .|..|:..::.|   ..:|..|    :.|..|| ||.    |:|....|.
Zfish   297 ANITVPQVERRDEEKIYYKIQAKELATLAPAIDWMPF----LSSVFAPVELNNSEPVVVYAKEYL 357

  Fly   280 TALKELMDKQDARLVASYI---MTRFAIFLLD-----------ETMGGREST------ECVSQVR 324
            ..:.||:...:..::.:|:   :.|..:.:||           |.|.|.:.:      .|||...
Zfish   358 QKVSELISNTNKSVLNNYMIMKVVRKMVSILDQKFQDAEQRFLEVMYGTKKSCMPRWKLCVSDTD 422

  Fly   325 RNMNLAANMLY-KERFFEDS-TFSANILEIKDIFEKLRHQFLLQVDQNHLELTALQ----MKFFV 383
            ..:..|...|: |..|.||| .|      ::|:..:::..|     ::.|:..:..    .|...
Zfish   423 SALGFALGALFVKATFSEDSKAF------VEDMVSEIKWAF-----EDSLKTVSWMDPETKKAAK 476

  Fly   384 RKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELD-----YHQEHLKVLQFRTQKMLAQSSK 443
            .||:|| .|:|..||      || ...::|.....:.|     |.|..:....|..:....|..|
Zfish   477 EKADAI-YNMVGYPK------FI-MNPKELDKVFNDFDVVSDLYFQNVMNYYNFSARVTADQLRK 533

  Fly   444 GHSEEQNILTYRSQAAPLPPPQ------------PFFQLESEDVFKYSLMGYIMAHHLISAFATE 496
            ..:.:|..:|..:..|...|.:            ||:.........:..:|.:|.|.|..||..:
Zfish   534 APNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHAFDDQ 598

  Fly   497 GITIGSDGN----DQSFRSHRFEEAVSCL-------SRNSE------NIDESMGDIAGLELAYFT 544
            |.....|||    .|:.....|:....|:       |.|:|      .:.|::.|..||..||..
Zfish   599 GRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEPLNGKHTLGENIADNGGLNAAYKA 663

  Fly   545 YAKMAKNRNRLDFTHLPP-----EQIFFLNVGQFFC-------GNSDMLVQ-YKEDQVRLQRAIE 596
            |....|...  :...||.     .|:||:...|.:|       .:..::.. :...:.|:...|.
Zfish   664 YVNWIKKNG--EEASLPALGMNNHQLFFVGFAQVWCSVRTPESSHEGVITDPHSPSRFRVIGTIS 726

  Fly   597 GFEPFDKAFGCYRNKPKH--EKCRL 619
            ....|.:.|||..:.|.:  .||.|
Zfish   727 NSHEFSEHFGCKADSPMNPKRKCEL 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	145/709 (20%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	149/719 (21%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	145/709 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010