DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl8 and mmel1

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_017213856.1	Gene:	mmel1 / 560703	ZFINID:	ZDB-GENE-101112-2	Length:	765	Species:	Danio rerio

Alignment Length:	734	Identity:	164/734 - (22%)
Similarity:	283/734 - (38%)	Gaps:	194/734 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ILSHVDKEANPCENYYNHACGQYNMRHI---DDTFFDIIQMLDHQVNQNLVKLMDELEMSSQLPD 85
            :|.::|...:||:|:|.:|||.:..||:   ..:...:..:|..::.   :.|...|||.::  |
Zfish    87 LLQNMDPSVDPCQNFYQYACGGWIERHVIPETSSLHSVFNILRDELE---IVLKGVLEMENK--D 146

  Fly    86 FNVSSVDGKVLRYYLSCRG----APRNMDSLSQYLKVISPGEGLTWP--QFIPDGSS---WPQEN 141
            ...:....|.|  |.||..    ..|:...|.:.:..|.     .||  ..:.:|:|   |..|:
Zfish   147 DREAFKKAKTL--YSSCMNEILIEQRDSQPLLRLIDSIG-----DWPVASEVWNGTSEQTWSLED 204

  Fly   142 FKWLKALAHLH-RYGLTNVFFNLEVVSNPRNASEYMVELNTPTFGEES-----------QLPNSF 194
                 .||.|: ||....| ..:.|..:.|::|.|::.::.|..|..|           ::..::
Zfish   205 -----TLAVLNGRYNKKAV-LEMFVWPDDRDSSRYIIHVDQPALGMPSRDYYLSDGNYKKVREAY 263

  Fly   195 IEILSVLYIIKVPSSEIITLAR-----------KMRTLE-----LLLKTMI----------NPID 233
            :|.:             :::||           :.|.||     |.|:|.|          |.|.
Zfish   264 LEFM-------------VSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAEERNDIT 315

  Fly   234 TLNNRYISIRDFQME---TGHNWQRFFEILIGS---SAAPELQVLVRNFRYFTALKELMDKQDAR 292
            .|.|: :::|:.|..   .|.||.|:.:.::.|   |...:..:::....|...|.|::.|...|
Zfish   316 VLYNK-MTLREAQQTFNLNGFNWTRYIQGIMSSVSISVQSDEPIVIYCSPYLEKLSEVLSKHSHR 379

  Fly   293 LVASY-----IMTRFAIF--------------LLDETMGGRESTECVSQVRRNMNLAANMLYKER 338
            .:.:|     ||.|.:..              |...|:......:||..|:.||..|...||..
Zfish   380 TLQNYLVWMLIMDRVSSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNMENAVGALYVR- 443

  Fly   339 FFEDSTFSANILE-IKDIFEKLRHQFLLQVDQNHLELTALQMKFFVR-KAEAIEINVVNLPK--T 399
                .|||.|... :.::.:|::..::..:::  |.....|.|...| ||.||. ..:..|.  .
Zfish   444 ----ETFSGNSKRMVGELIKKIQEAYVETLEE--LSWMDEQSKVKAREKAMAIS-EQIGYPDHIL 501

  Fly   400 DDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKMLAQSSKGH------------------- 445
            ::....:.|.|..|.|  .|.:|.:..|       :.:.|.:.|||
Zfish   502 EEENKKLDQEYAHLNF--SEENYFENIL-------ENLAASAQKGHKKLREPVDPDMWIIGAAVV 557

  Fly   446 ----SEEQNILTYRSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGND 506
                |..:|.:.:  .|..|.|  |||..:......:..:|.::.|.:...|...|.....|||.
Zfish   558 NAFYSHNRNQIVF--PAGILQP--PFFSEKQLQALNFGGIGMVIGHEITHGFDDHGRNFDKDGNM 618

  Fly   507 ----QSFRSHRFEEAVSCLSR----------NSENID------ESMGDIAGLELAYFTYAKMAKN 551
                .::.:.|||:...|:..          ..:|:.      |::.|..|:..||..|.|..:.
Zfish   619 YNWWSNYSAERFEDQSKCMVEQYGRFSWKLAGGQNVSGITTLGENIADNGGVRQAYKAYVKWVER 683

  Fly   552 RNR------LDFTHLPPEQIFFLNVGQFFCG--NSDMLVQ-YKED-----QVRLQRAIEGFEPFD 602
            ...      ||..|   :|:||||..|.:||  ..:..:| .|.|     :.|:..:::.||.|.
Zfish   684 EGEEPRLPGLDMNH---KQLFFLNFAQVWCGACRPEYAIQTIKTDPHSPLEYRVLGSLQNFEAFS 745

  Fly   603 KAFGCYRNKPKH--EKCRL 619
            :||.|.|..|.:  ||||:
Zfish   746 EAFHCARGAPMNPEEKCRV 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	160/723 (22%)
mmel1	XP_017213856.1	PepO	88..765	CDD:226118	164/733 (22%)
mmel1	XP_017213856.1	M13	95..763	CDD:189000	160/723 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010