Protein Alignment Nepl8 and PHEX

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 147/735 - (20%)
• Similarity: 270/735 - (36%)
• Gaps: 191/735 - (25%)

  Fly    24 ILSHVDKEANPCENYYNHACGQY---NMRHIDDTFFDIIQMLDHQVNQNLVKLMD---------- 75
            |||.|:...:||:|::..||..:   |....|...:.:...|.|.|:..|.:|::
Human    66 ILSKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTE 130

  Fly    76 -----ELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGLTWP----QFI 131
                 ::..||.:.:..:...|.|.|.:.|  |.:|                  ..||    ...
Human   131 AIQKAKILYSSCMNEKAIEKADAKPLLHIL--RHSP------------------FRWPVLESNIG 175

  Fly   132 PDGSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVELNTPTFG---EESQLPNS 193
            |:| .|.:..|..|:.||........:||..|.|..:.:.::|::::|:..|..   .|..|.||
Human   176 PEG-VWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNS 239

  Fly   194 FIEILS---VLYIIKVPSSEII-------------TLARKMRTLELLLKTMINPIDTLNNRYISI 242
             .|..|   .||...|.::.::             .|..:::..|:::.......:.:.|: ::|
Human   240 -TEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNK-MNI 302

  Fly   243 RDFQ-METGHNWQRFFEILIGSSAAPELQ-------VLVRNFRYFTALKELMDKQDARLVASYIM 299
            .:.. |....:|..:.:.:|.:...|.|:       |:||..:||..|..::..:..:.:|:|::
Human   303 SELSAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLV 367

  Fly   300 TR-------------------FAIFLLDETMGGRESTECVSQVRRNMNLAANMLYKERFFEDSTF 345
            .|                   |:..:...|....:..:||:.:...:......::.:.:|::.
Human   368 WRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQED-- 430

  Fly   346 SANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYY 410
            ...::|  ::.|.:|..|:..:::.:..:.|...:....||.|: :..|..|:      ||..
Human   431 KKEMME--ELVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAV-LAKVGYPE------FIMN-- 484

  Fly   411 QDLQFPTGELDYH-QEHLKVLQF----------RTQKMLAQS---------------------SK 443
                      |.| .|.||.::|          :|:|.||||                     :.
Human   485 ----------DTHVNEDLKAIKFSEADYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNA 539

  Fly   444 GHSEEQNILTYRSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGNDQS 508
            .:|...|.:  |..|..|..|. |:..|......|..:|.|:.|.....|...|.....:||...
Human   540 FYSASTNQI--RFPAGELQKPF-FWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDP 601

  Fly   509 FRS----HRFEEAVSCLSRNSEN---------------IDESMGDIAGLELAYFTYAKMAKNRNR 554
            :.|    .:|:|...|:.....|               :.|::.|..||..|:..|.|...:|.:
Human   602 WWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQ 666

  Fly   555 ---------LDFTHLPPEQIFFLNVGQFFCGN--------SDMLVQYKEDQVRLQRAIEGFEPFD 602
                     :.||:   .|:|||:.....|.:        ...:..:...|.|:..||..||.|.
Human   667 GLEEPLLPGITFTN---NQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQ 728

  Fly   603 KAFGCYRNKPKH---EKCRL 619
            |||.|..|...:   :.|||
Human   729 KAFNCPPNSTMNRGMDSCRL 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	140/724 (19%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	140/724 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910