DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl8 and Nepl21

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	168/744 - (22%)
Similarity:	295/744 - (39%)	Gaps:	180/744 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ICL---LLVPLVAAS--------SNTRLLNGIL---------SHVDKEANPCENYYNHACGQYNM 48
            ||:   :|..:|||:        .:|..:..:|         |.:|::|:||.::|..:||.|
  Fly    15 ICIAGHVLSAMVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNY-- 77

  Fly    49 RHIDDTF------FDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPR 107
            :.|:...      ..:.:.|...:|:.::|:::....|...|:      |.||..:|.||.....
  Fly    78 KRINSALSMQVVTTGVFETLTKGLNRKILKMLNTPHDSHDTPE------DIKVKHFYESCLQIKE 136

  Fly   108 NMDSLSQYLKVISPGEGLTWPQFIPDGSSWPQENFKWLKALAHL-HRYGLTNVF---FNLEVVSN 168
            ...:.|:.||.:....| |.|  :.:||||.:::|.||...|.: :|||:|.:|   .|.::.||
  Fly   137 LNSTYSEKLKRLIAEFG-TMP--LLEGSSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASN 198

  Fly   169 PRNASEYMVELNTPTFGEESQLPNSFIEILSVLY---------------------IIKVPSSEII 212
            .||    .:.|....|..|::  :.:::..:.:|                     :.|..:.|:|
  Fly   199 TRN----RIYLGQQDFPLEAR--SMYVDDATAVYRQKYRNNIQRILQRYLGVKMDLAKKTAKELI 257

  Fly   213 T--------LARKMRTLELLLKTMINPIDTLNNRYISIRDFQMETGHNWQRFFEILIGSSAAPEL 269
            .        |..:...|::...|.:..:|.:..||....|.        .|...:.:|...:.
  Fly   258 DFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLDI--------DRLLFVSMGERISD-- 312

  Fly   270 QVLVRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLDETMGG---RESTECVSQVR----RNM 327
            |:...|.||...|.|::.:...|.||:||..|. |:...||...   ::...||...:    :|:
  Fly   313 QIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRL-IWEFVETPSDSPEKQMKACVDLTKKYFAKNL 376

  Fly   328 NLAANMLYKERFFEDSTFSANIL--EIKDIF-EKLRHQFLLQVDQNHLELTALQMKFFVRKAEAI 389
            :   ||.|:....|.|:...:.:  ::|..| |.||....|    |.:|.....:.....:|..:
  Fly   377 D---NMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPAL----NWIERPTRNLAMAKLQAMTL 434

  Fly   390 EIN------------VVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKMLAQSS 442
            |:|            .:|| ::||       |.::::: |..|...|  ::.:..:..|.....|
  Fly   435 EVNNYADDNFTEEFAELNL-QSDD-------YVENVRY-TSLLGAKQ--MREMLHKPAKPFEAGS 488

  Fly   443 KGHSEEQNILTYRSQAAPLPPPQPFFQLESEDVFKYSLM----GYIMAHHLISAFATEGITIGSD 503
            :......|||...:...|:...|||:..  .||:..::|    ..::.|.||..|...|......
  Fly   489 QLSYTPANILIENTIKVPVALLQPFYIW--SDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEK 551

  Fly   504 GNDQSF----RSHRFEEAVSCLSR-----------------NSENIDESMGDIAGLELAYFTYAK 547
            ||.:.:    .|..|.:...|.::                 .||||    .|..|:.|||..|.|
  Fly   552 GNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENI----ADNGGMRLAYTAYRK 612

  Fly   548 MAKNRNRL-----DFTH--LP-----PEQIFFLNVGQFFCGNSDMLV--------QYKEDQVRLQ 592
            ..:|:..|     |.|.  ||     .:|:||::..|.:|.::...|        |:...:.|:.
  Fly   613 WYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVI 677

  Fly   593 RAIEGFEPFDKAFGCYRNKPKH--EKCRL 619
            .::..||.|.|.|.|......:  |||.|
  Fly   678 GSLSNFEEFSKEFNCPAGSAMNPSEKCIL 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	156/693 (23%)
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	160/702 (23%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	155/692 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940