DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl8 and Nepl20

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	760	Identity:	168/760 - (22%)
Similarity:	291/760 - (38%)	Gaps:	209/760 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWIIC-LLLVPLVAASSNTRLLN----------------GILSHVDKEANPCENYYNHACGQY-- 46
            :||.. :|.|.::||.::..:||                .|.|.::::.:||:::|..:||.|
  Fly     8 IWIASHVLSVLVLAAPTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKR 72

  Fly    47 -----NMRHIDDTFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCRGAP 106
                 |||.:....|   :.|...:|:.::|:::....|...|:      |.:|..:|.||....
  Fly    73 INSALNMRVLTTGVF---ETLTKGLNRKILKMLNTPHDSHDTPE------DIQVKHFYESCLQIK 128

  Fly   107 RNMDSLSQYLKVISPGEGLTWPQFIPDGSSWPQENFKWLKALAHL-HRYGLTNVFFNLEVVSNPR 170
            ....:.|:.||.:....| |.|  :.:||||.:::|.||...|.: ||||:.:: ..:.|.::..
  Fly   129 ELNSTYSEKLKRLIAEFG-TMP--LLEGSSWQEDDFDWLNTTARMAHRYGIMSI-IGVGVATDFA 189

  Fly   171 NASEYMVELNTPTFGEESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTLELLLKTMI------ 229
            |..:.::.:|...|                              ..|.|::.:..:|.|
  Fly   190 NNQKNIIYINQQEF------------------------------PLKTRSMYMDNETAIYRQNYQ 224

  Fly   230 NPIDTLNNRYISIRD------------FQMETGH---------NWQRFFEIL----IGSSAAPEL 269
            |.|..:..:|:.::|            |:::..|         |.:...|:|    :....||.|
  Fly   225 NNIQLILEKYLGVKDELARKAAKEMFEFEVDLAHGLVDNNKHLNLRDLIELLTVAELRERYAPTL 289

  Fly   270 ----------------QVLVRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLDETMGGRES-T 317
                            :|...|.||...|.|::::.....||:|:..|.....:.:..|..|. |
  Fly   290 DTDQLIFVSMGEKISDKVYEYNRRYQQNLVEVIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPT 354

  Fly   318 E-CVSQVR----RNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLELTAL 377
            | ||...:    :|::   ||:|:....|.|:     .||..::.:|:..|    .:..|...||
  Fly   355 EACVDFTKTYFAKNLD---NMIYRRYKNEKSS-----REIDSMWHQLKSTF----KETLLSSPAL 407

  Fly   378 Q------MKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQK 436
            .      ....:.|.||:.:.|.|..|.:....|     .||.....:...:...:::||.:..:
  Fly   408 DWIEPSTRSLAIAKLEAMTLEVNNYVKENFTEEF-----ADLNLQNTDCVENLRQVQMLQAKQMR 467

  Fly   437 MLAQSSKGHSEEQNILTY--------RSQAAPLPPPQPFFQLESEDVFKYSLM----GYIMAHHL 489
            .|........|...:|:|        .|...|:...|||:..  .||:..::|    .|::.|.|
  Fly   468 QLYHQPAKPLEAGELLSYTPSNILLENSIKVPVALLQPFYIW--SDVYPNAVMFGTLAYLIGHEL 530

  Fly   490 ISAFATEGITIGSDGNDQSF----RSHRFEEAVSCLSR-----------------NSENIDESMG 533
            |..|...|......||.:.:    .|..|.:...|.::                 .||||    .
  Fly   531 IHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENI----A 591

  Fly   534 DIAGLELAYFTYAKMAKNRNRL-----DFTH--LP-----PEQIFFLNVGQFFCGNSDMLVQYKE 586
            |..|:.|||..|.|..:|:..|     |.|.  ||     .:|:||::..|.:|  :|:..:.|.
  Fly   592 DNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWC--NDVHPKVKA 654

  Fly   587 DQV----------RLQRAIEGFEPFDKAFGCYRNKPKH--EKCRL 619
            .||          |:...:..||.|.|.|.|:.....:  |||.|
  Fly   655 LQVSTDDHMPGKFRVIGTLSNFEEFSKEFNCHAGSAMNPIEKCIL 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	156/709 (22%)
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	155/708 (22%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	155/708 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454891
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840