DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nepl8 and MME

DIOPT Version :9

Sequence 1:NP_609795.2 Gene:Nepl8 / 34983 FlyBaseID:FBgn0032585 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_000893.2 Gene:MME / 4311 HGNCID:7154 Length:750 Species:Homo sapiens


Alignment Length:767 Identity:180/767 - (23%)
Similarity:299/767 - (38%) Gaps:207/767 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IICLLLVPLVA--------ASSNTRLLNGILSHVDKEANPCENYYNHACGQYNMRH-IDDTF--- 55
            ||.:.::.|.|        :|...:....::.::|....||.:::.:|||.:..|: |.:|.   
Human    40 IIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRY 104

  Fly    56 --FDIIQMLDHQVNQNLVKLMDELEMSSQLPDF-------NVSSVDGKVLRYYLSCRGAPRNMDS 111
              |||              |.||||:  .|.|.       ::.:|. |....|.||..... :||
Human   105 GNFDI--------------LRDELEV--VLKDVLQEPKTEDIVAVQ-KAKALYRSCINESA-IDS 151

  Fly   112 LSQYLKVISPGEGLTWPQFIPDGSSWP--QENFK------WL--KALAHLH-RYGLTNVFFNLEV 165
            ..        ||.|.  :.:||...||  .||::      |.  ||:|.|: :|| ..|..||.|
Human   152 RG--------GEPLL--KLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYG-KKVLINLFV 205

  Fly   166 VSNPRNASEYMVELNTPTFGEESQLPN---------------SFIE-ILSVLYII----KVPSSE 210
            .::.:|:..:::.::.|..|    ||:               :::: ::||..:|    ::|..|
Human   206 GTDDKNSVNHVIHIDQPRLG----LPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDE 266

  Fly   211 IITLARKMRTLELLLKTMIN----PID-----TLNNRYISIR---DFQMETG---HNWQRFF-EI 259
             ..||.:|..:..|.|.:.|    |.|     .|.|:....:   :|.:|..   .:|..|. ||
Human   267 -NQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEI 330

  Fly   260 L--IGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLD-------------- 308
            :  :..|...|..|:|....|.|.||.::.|..||.:.:.:..||.:.|:.              
Human   331 MSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFR 395

  Fly   309 ETMGGRES-----TECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVD 368
            :.:.|..|     ..|.:.|..||..|...||.|..|...  |.:::|  |:..::|..|:..:|
Human   396 KALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGE--SKHVVE--DLIAQIREVFIQTLD 456

  Fly   369 QNHLELT---ALQMKFFVRKAEAIEINVVNLPKTDDL---RHFIGQYYQDLQFPTGELDYHQEHL 427
                :||   |...|....||.||: ..:..|  ||:   .:.:...|.:|.:.  |.:|.:..:
Human   457 ----DLTWMDAETKKRAEEKALAIK-ERIGYP--DDIVSNDNKLNNEYLELNYK--EDEYFENII 512

  Fly   428 KVLQFRTQKML----------------AQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESEDVF 476
            :.|:|...|.|                |..:..:|..:|.:.:  .|..|.|  |||..:..:..
Human   513 QNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVF--PAGILQP--PFFSAQQSNSL 573

  Fly   477 KYSLMGYIMAHHLISAFATEGITIGSDGN------DQSFRSHRFEEAVSCLSRNSEN-------- 527
            .|..:|.::.|.:...|...|.....||:      .||  :..|:|...|:.....|        
Human   574 NYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQS--ASNFKEQSQCMVYQYGNFSWDLAGG 636

  Fly   528 --------IDESMGDIAGLELAYFTYAKMAKNRNR------LDFTHLPPEQIFFLNVGQFFCG-- 576
                    :.|::.|..||..||..|....|....      ||..|   :|:||||..|.:||  
Human   637 QHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNH---KQLFFLNFAQVWCGTY 698

  Fly   577 ------NSDMLVQYKEDQVRLQRAIEGFEPFDKAFGCYRN---KPKHEKCRL 619
                  ||.....:.....|:...::....|.:||.|.:|   .|: :|||:
Human   699 RPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPE-KKCRV 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nepl8NP_609795.2 GluZincin 32..618 CDD:301352 172/727 (24%)
MMENP_000893.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Stop-transfer sequence. /evidence=ECO:0000255 16..23
M13 79..748 CDD:189000 172/725 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3590
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11733
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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