DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl8 and Ece2

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	154/728 - (21%)
Similarity:	267/728 - (36%)	Gaps:	207/728 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RLLNGILSHVDKEANPCENYYNHACGQYNMRH---IDDTFFDIIQMLDHQVNQNLVKLMDELEMS 80
            |:...||..:|:..:||:::|..:||.:..|:   ...:.::....|..| ||.::|.:  ||.|
  Rat   248 RVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPSGRSRWNTFNSLWDQ-NQAILKHL--LENS 309

  Fly    81 SQLPDFNVSS-VDGKVLRYYLSC--------RGAPRNMDSLSQYLKVISPGEGLTWPQFIPDGSS 136
            :    ||.|| .:.|...:||||        .||....|.:.:.     .|..:|.|
  Rat   310 T----FNSSSEAERKTRSFYLSCLHLERIEKLGAKPLQDLIDKI-----GGWNITGP-------- 357

  Fly   137 WPQENF-KWLKALAHLHRYGLTNVFFNLEVVSNPRNAS--------------------------- 173
            |.::|| :.|||:|..:|   ...||.:.|.::.::::
  Rat   358 WDEDNFMEVLKAVAGTYR---AAPFFTVYVGADSKSSNSNIIQVDQSGLFLPSRDYYLNRTANEK 419

  Fly   174 ------EYMVELNTPTFGEESQLPNSFIEILSV---LYIIKVPS---------------SEIITL 214
                  :|||||.....|:.:.......::|.:   |..|.||.               ||:.||
  Rat   420 VLAAYLDYMVELGMLLGGQPTSTRAQMQQVLELEIQLATITVPQDQRRDEEKIYHKMSISELQTL 484

  Fly   215 ARKMRTLELLLKTMINPIDTLNNRYISIRDFQMETGHNWQRFFEILIGSSAAPELQVLVRNFRYF 279
            |..|..|| .|..:::|::                           :|.|.    .|:|....|.
  Rat   485 APSMDWLE-FLSFLLSPLE---------------------------LGDSE----PVVVYGTEYL 517

  Fly   280 TALKELMDKQDARLVASYIM------------TRFAIF---LLDETMGGRES-----TECVSQVR 324
            ..:.||:::.:..::.:|::            .||...   ||:...|.::|     ..|:|...
  Rat   518 QQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTD 582

  Fly   325 RNMNLAANMLYKERFFEDST---FSANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKA 386
            ..:..|...|:.:..|:..:   ....|.||:..||:.... |:.:|    |.|.|..|   .||
  Rat   583 DALGFALGSLFVKATFDRQSKEIAEGMISEIRAAFEETLEN-LVWMD----EKTRLAAK---EKA 639

  Fly   387 EAIEINVVNLP-------KTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKMLAQSSKG 444
            :|| .:::..|       :.||:       |..  :...|..:.|..|.:..|..:.|..|..|.
  Rat   640 DAI-YDMIGFPDFILEPRELDDV-------YDG--YEVSEDSFFQNMLNLYNFSAKVMADQLRKP 694

  Fly   445 HSEEQNILTYRSQAAPLPPPQ------------PFFQLESEDVFKYSLMGYIMAHHLISAFATEG 497
            .|.:|..:|.::..|...|.:            ||:.........:..:|.:|.|.|..||..:|
  Rat   695 PSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQG 759

  Fly   498 ITIGSDGNDQ---------SFRSHR--FEEAVSCLSRNSENID------ESMGDIAGLELAYFTY 545
            .....:||.:         :|::|.  .||..:....|.|.::      |::.|..||:.||..|
  Rat   760 REYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAAYNAY 824

  Fly   546 AKMAKNRNR---LDFTHLPPEQIFFLNVGQFFC------GNSDMLV--QYKEDQVRLQRAIEGFE 599
            ....:....   |....|...|:||:...|.:|      .:.:.||  .:...:.|:...:....
  Rat   825 KAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSR 889

  Fly   600 PFDKAFGCYRNKP 612
            .|.:.|||....|
  Rat   890 DFLRHFGCPVGSP 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	150/715 (21%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	153/726 (21%)
		M13	261..910	CDD:189000	150/715 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910