Protein Alignment Nepl8 and Nep2

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001246914.1
• Gene: Nep2 / 40588
• FlyBaseID: FBgn0027570
• Length: 774
• Species: Drosophila melanogaster
• Alignment Length: 777
• Identity: 149/777 - (19%)
• Similarity: 271/777 - (34%)
• Gaps: 247/777 - (31%)

  Fly     4 ICLLLVPLVAASSNTRLLNGILSHVDKEANPCENYYNHACGQY-NMRHIDD------TFFDIIQM 61
            :||....:..||:       :|..:..|..||:|:|..|||.| ...:|.|      ||..|...
  Fly    83 VCLTQECIHTAST-------VLRKMKPEVEPCDNFYEFACGTYLEEENIPDDKVSISTFSVISDK 140

  Fly    62 LDHQVNQNLVKLMDELEMSS-QLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGL 125
            |..|:...:.....|.|... :||:....:...|.|                   ::.:.| |.:
  Fly   141 LQEQLKDIITAERPETEPKHFRLPNLLYKACMNKTL-------------------IETLGP-EPI 185

  Fly   126 T--------WPQFIPDGSSW-PQENFKWLKALAHLHRYGLT-NVFFNLEVVSNPRNASEYMVELN 180
            |        ||  :..|.|| ..:::.|.:.:......|.: :...:..:..:.:|:::.:::|:
  Fly   186 TRVAERLGGWP--LIKGDSWNADDSWTWQEQVKKFRTAGFSMDYIIDFSIGVDLQNSTKRLIDLD 248

  Fly   181 TPTFG-EESQLPNSFIE-ILSVLYIIKVPSSEIITLARKMRTLELLLK-----TMIN---PIDTL 235
            ..:.. ....|...|.| :::..|...|..:.:....|.:...||||.     .:.|   |.:..
  Fly   249 QSSLALSREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTELLLSLEFEMALANISWPNEKR 313

  Fly   236 NNR---YISIRDFQMETGH---NWQRFFEILI--GSSAAPELQVLVRNFRYFTALKELMDKQDAR 292
            .|.   |......|::..:   .|..:...|:  |.:.|.:..:.:....:|..|.:|:.|...|
  Fly   314 RNSSELYNLRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKR 378

  Fly   293 LVASYIMTR---FAIFLLDE-----------TMGGRES-----TECVSQVRRNMN---------- 328
            ::|:|:..|   |::..|.|           .:.||:.     .|||.....:|:
  Fly   379 VIANYMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSL 443

  Fly   329 -LAANMLY-KERFFEDSTFSANIL----EIKDIF------------------------------- 356
             ::...|| .:.|.:||  .||.|    ||:::|
  Fly   444 GISVGSLYVGKHFHKDS--KANALEMVNEIRNVFNDILDEVNWMDAKTKKEAKLKLHSMATHIGY 506

  Fly   357 -------EKLRHQFL-LQVDQNHLELTALQMKFFVRKAEAIEINVVNLP--KTDDLRH----FIG 407
                   |||...:. |.:|.:....:.|.|..|   ......|.:.||  |||.:||    .:.
  Fly   507 PDEMLDNEKLAAYYAKLDIDPDKYFESFLGMNIF---GTDYSFNKLRLPVNKTDWVRHARPAIVN 568

  Fly   408 QYYQDL----QFPTGELDYHQEHLKVLQFRTQKMLAQSSKGHSEEQNILTYRSQAAPLPPPQPFF 468
            .:|..|    |||.|          :||            ||                     ||
  Fly   569 AFYSSLENSIQFPAG----------ILQ------------GH---------------------FF 590

  Fly   469 QLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGNDQSF------------------RSHRFE 515
            ..:......:..:||::.|.:...|..:|......||.:.:                  :...:.
  Fly   591 NAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDWWHPDTQKAYLAKAKCIIEQYGNYT 655

  Fly   516 EAVSCLSRNSENID-ESMGDIAGLELAYFTYAKMAKNRN------RLDFTHLPPEQIFFLNVGQF 573
            |..:.|:.|..|.. |::.|..|::.:|..|.:.|:...      .||:|   |||:|::..||.
  Fly   656 ERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEKHGPEAKLPGLDYT---PEQMFWVAAGQT 717

  Fly   574 FCGNSDMLVQYKEDQVRLQ--------------RAIEGFEPFDKAFGCYRNKPKH--EKCRL 619
            :|      .:|:::.::::              .::...:.|.|.|.|....|.:  :||.:
  Fly   718 WC------AKYRKESLKMRITTGVHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEV 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	142/746 (19%)
Nep2	NP_001246914.1	M13	104..772	CDD:189000	142/746 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910