DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl8 and phex

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001307259.1	Gene:	phex / 386969	ZFINID:	ZDB-GENE-030103-2	Length:	745	Species:	Danio rerio

Alignment Length:	761	Identity:	173/761 - (22%)
Similarity:	299/761 - (39%)	Gaps:	192/761 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ICL-LLVPLVAAS---SNTRLLNG---------ILSHVDKEANPCENYYNHACGQY---NMRHID 52
            :|: ||:.::..|   ||..|..|         |||.:|:..:||:::|.:|||.:   |....|
Zfish    31 VCIALLIAVITVSQKASNEDLCLGPHCVEAAGSILSKMDQSVDPCDDFYQYACGGWLRENPIPED 95

  Fly    53 DTFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSSV-DGKVLRYYLSCRG-APRNMDSLSQY 115
            .:.:.|...|...|:..|.:|:::...|.     ::.:| ..|||  |.||.. :...::..:..
Zfish    96 SSSYGIYPWLRQNVDLKLKELLEQPVRSG-----DIEAVKKAKVL--YASCMNESALEIEDANPL 153

  Fly   116 LKVISPGEGLTWP---QFIPDGSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMV 177
            ||.:...| ..||   ..:...|.|.:..|..|:.||.:......:|...|.|..:.:|:::|::
Zfish   154 LKNLKQKE-FRWPVLGDALGSSSRWVESQFNLLETLAQIRSQHSKSVLIRLFVAPDDKNSNQYII 217

  Fly   178 ELNTPTFG-----------EESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTL--ELLLKTMI 229
            :|:..:..           .|:|:....:..|.|...:.:.:||....|:....|  |:.|..::
Zfish   218 KLDQASLSLSSREDYITNTTEAQMYREALLRLMVDVSVMLGASEQAAEAQMKSVLDFEMKLAQIV 282

  Fly   230 NPI-----DTLNNRYI------SIRDFQMETGHNWQRFFEILIGSSAAPEL------QVLVRNFR 277
            .|.     :.:.|:|.      ::.||      ||..|...:|.:...|:|      ||:||..:
Zfish   283 IPYENRTSENMYNKYSLSKLQRTVPDF------NWLGFVRAVIDTELYPDLKISSSEQVIVRAPQ 341

  Fly   278 YFTALKELMDKQDARLVASYIM------------TRFAIFLLD---ETMGGREST----ECVSQV 323
            ||..|.:|::..|.|.||:|::            .||....||   .|.|....|    :||:.|
Zfish   342 YFKDLFKLINATDTRTVANYVIWRSVFSRITTLSRRFLYRYLDFARVTTGTTSLTPRWDKCVNYV 406

  Fly   324 RRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEA 388
            ...:..||..|:.::.|::.  ..:::|  ::...:|..|:..:::.:..:.....:..:.||.|
Zfish   407 ENTLIYAAGRLFVDKHFQED--KKHMME--ELINGIRWAFIDILEKENEWMDEETKRKAIDKAHA 467

  Fly   389 IEINVVNLPKTDDLRHFIGQYYQDLQFPTGELD--YHQEHLKVLQF----------RTQKMLAQS 441
            :      |||       :|       :|...|:  |..|.:|.|.|          :|.|.:|||
Zfish   468 V------LPK-------VG-------YPDFILNDTYINEDIKRLAFTMTDYFGNVMQTLKFIAQS 512

  Fly   442 SKG---------------------HSEEQNILTYRSQAAPLPPPQPFFQLESEDVFKYSLMGYIM 485
            ..|                     :|...|.:  |..|..|..|. |:.|.......|..:|.|:
Zfish   513 DIGWLRKTVPRTEWFTNPTTVNAFYSSSTNQI--RFPAGELQKPF-FWGLNYPRSLSYGAIGVIV 574

  Fly   486 AHHLISAFATEGITIGSDGN-DQSFRS---HRFEEAVSCL---------------SRNSENIDES 531
            .|.|...|...|.....||| ||.:.:   :||.|...|:               .:....:.|:
Zfish   575 GHELTHGFDNNGRKYDKDGNLDQWWSNSSINRFTEKTQCMIDQYNSYYWKEAGLNVKGKRTLAEN 639

  Fly   532 MGDIAGLELAYFTYAK-MAKNRNRLDFTHLP-----PEQIFFLNVGQFFCGNSDMLVQYK----E 586
            :.|..|:..::..|.: :.|.|..::...||     ..|:|||:.....|.      .|:    .
Zfish   640 IADNGGIRESFRAYRRWVEKERGGVEEPLLPGVGLTHNQLFFLSYAHVRCN------AYRPEAAR 698

  Fly   587 DQV----------RLQRAIEGFEPFDKAFGCYRNKPKH---EKCRL 619
            ||:          |:..|:..||.|.|||.|......:   |.||:
Zfish   699 DQIQSGAHSPPKYRVIGAMSNFEEFRKAFNCPETSIMNRGAESCRV 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	159/717 (22%)
phex	NP_001307259.1	PepO	61..744	CDD:226118	164/729 (22%)
phex	NP_001307259.1	M13	72..743	CDD:189000	159/717 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910