Protein Alignment Nepl8 and Nepl3

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_608904.1
• Gene: Nepl3 / 326172
• FlyBaseID: FBgn0031678
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 660
• Identity: 152/660 - (23%)
• Similarity: 285/660 - (43%)
• Gaps: 110/660 - (16%)

  Fly     2 WIICLLLVPLVAASSNTRLLNGILSHVDKEANPCENYYNHACGQYNMR-HIDDTFFDIIQMLDHQ 65
            |::.||...:.:|:.|..::..:|..:|::..||.|:||.:  |.|:: |...|..|..|:|...
  Fly    12 WLLLLLCSTVCSANPNLEIMKRMLDDMDEKVEPCHNFYNSS--QKNLKWHAFATVSDQFQLLFDG 74

  Fly    66 VNQNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGLTWPQF 130
            :...:               |...|.:.|:.|.|..|....|  .||.:|.:::.|||.|.||..
  Fly    75 IENEV---------------FEKHSFEEKLQRLYKICSTMER--PSLLRYFELVKPGEDLNWPFL 122

  Fly   131 IPDGSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVELNTPTFGEESQLPNSFI 195
            .|.|..||:|.|:|::|||.|.|||..::.|.:.:..:|.:.|...:.:....:       :|..
  Fly   123 TPRGGKWPKEKFQWMEALARLRRYGFNDIMFGMSIRQDPNSDSGQPIVVFEKKY-------DSLF 180

  Fly   196 EILSVLYIIKVPSSEIITLARKMRTLELLLKTMIN--------PIDTLNNRYISIRDFQMETGHN 252
            ..:..|..|.:|..    ||:::..|:..::.|..        ..|....:.||:...:: .|.:
  Fly   181 RFIESLQNIGLPPK----LAKEIAPLDNAIQEMYKSDMKFEHYARDAAPVKRISLGQLEI-YGVS 240

  Fly   253 WQRFFEILIGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLDETMGGREST 317
            ..::.||:.|...:|:..|.|.|..|...|:.||....:::||:|:..||:.:::...|  :...
  Fly   241 LTKYLEIVFGRPFSPDFVVHVENLYYLRGLQNLMTAVPSQVVANYLTARFSFYIMFTFM--KHGD 303

  Fly   318 ECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFF 382
            .||:.:|::|..|:|:|::||........:...:...||:.:|.|..:::::|.|:|...::...
  Fly   304 SCVTTMRQSMEFASNLLFEERILGRKKLRSYQNQAGKIFDAIRQQLNIRLERNVLKLPPAEISLL 368

  Fly   383 VRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKMLAQSSKGHSE 447
            .:|...:.:::.|||.....|.|:.:||::|:|...| :....|||||:.||:..|:...:.:.:
  Fly   369 QKKLNGLSLSIGNLPGKAGHRRFVTRYYKELEFADDE-ELATAHLKVLEHRTRAELSLLDQPNFK 432

  Fly   448 EQNIL-------------TYRSQAAPLPPPQPF-----FQLESEDVFKYSLMG------------ 482
            ::..:             .|......:.....|     |..:|.|:||.:.:|
  Fly   433 DRRYMLHSYPISNFFFETAYEENGNTIYVAYDFLADASFDPDSHDIFKVTPLGIRFGLEMLKSFD 497

  Fly   483 -YIMAHH---LISAFATEGITIGSDGNDQSFRSHRFEEAVSCLSRNS--ENIDESMGDIAGLELA 541
             :...||   ::..|....||...|            |.||..::::  ...|:.:..:..:..|
  Fly   498 LFNCKHHKVNMLQLFDDNQITTAGD------------ECVSAWTQDNLLSQRDQYLVVLHLVHEA 550

  Fly   542 YFTYAKMAKNRNRLDFTHLPPEQIFFLNVGQFFCGNSDMLVQYKEDQVRLQRAIEGFEP------ 600
            ||........| :.:||.:...::||...||...|.:   :.:..|      .:||..|
  Fly   551 YFAEGSKFSQR-QPNFTTMSLRELFFFRFGQSSFGQT---LYFGSD------FVEGGSPINSLTR 605

  Fly   601 ---FDKAFGC 607
               |.:.|.|
  Fly   606 LPVFVRTFNC 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	145/630 (23%)
Nepl3	NP_608904.1	GluZincin	42..>434	CDD:472708	109/425 (26%)