Protein Alignment Nepl8 and frma

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_572226.2
• Gene: frma / 31464
• FlyBaseID: FBgn0029769
• Length: 611
• Species: Drosophila melanogaster
• Alignment Length: 670
• Identity: 156/670 - (23%)
• Similarity: 268/670 - (40%)
• Gaps: 139/670 - (20%)

  Fly    20 LLNGIL-----SHVDKEANPCENYYNHACGQYNMRHIDDTFFDIIQMLDHQVNQNLVKLMDELEM 79
            |:.|:|     ||  .:|:||:|:|..|||.::..|..|::...:..||:...:.|..|:|. |.
  Fly    10 LIVGLLVVQVKSH--PQADPCQNFYKVACGNWSASHATDSYESFMDRLDYNYQEKLADLLDN-ER 71

  Fly    80 SSQLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGLTWPQFIPDGSSWPQENFKW 144
            ....|.|.     .::..:|.:|| .|.:.|.:.:.|:.:...|.:...:.
  Fly    72 EDDEPHFL-----QQLRNFYTACR-KPLSQDQVLRILEHLIVMENIQNEEL-------------- 116

  Fly   145 LKALAHLHRYGLTNVFFNLEVVSNPRNASEYMV---------ELNTPTFGEESQLPNSFIEILSV 200
                    ..||| ..|.|:|:.:..:::.|.:         ..:..|...|......|.::.:.
  Fly   117 --------SVGLT-AAFRLQVLIDLNDSNTYDIWKQLMSHRKHWDPNTTNREPLTREMFDKLWAS 172

  Fly   201 LYIIKVPSSEIITLARKMRTLELLLKTMINPIDTLNNRYISIR--DFQMETGHNWQRFFEILIGS 263
            |..|..|..|...  |::..||..:.:..:..|..::..:..|  .|.|....|....:|.|  |
  Fly   173 LPKIPFPFKEYYW--RELSELEEKIMSYGSEDDGFDSGDLVTRIPPFWMMPWPNGNITYENL--S 233

  Fly   264 SAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLDETMGGRESTE--------CV 320
            ..|..|.:....|                 :.:||..|  :.|:.|.:    |||        |.
  Fly   234 QMAHWLDIKANEF-----------------ILTYIYMR--LKLVAEGV----STESWHIDRDQCA 275

  Fly   321 SQVRRNMNLAANMLYKE---RFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFF 382
            .|.|:.::..|..|.::   |..|:..       ::|||.:|:.:|..::..|....|.....|.
  Fly   276 EQSRQILSHPAAWLVEKNHPRLKEEPV-------LQDIFAELKQRFGQKLLANRNNFTRSTQHFL 333

  Fly   383 VRKAEAIEINVVNLPKTDDLRHF---IGQYYQDLQFPTGE--------LDYHQEHLKVLQ----- 431
            :.|.:.:.:.:..||:....:..   |.::|:|:.....:        |::.:.|.|..|
  Fly   334 LGKLKRMRLRLSILPRNSSAQSMVRRIERHYRDVHMNASDYFGNLHIGLNHSRSHKKYAQLWAIV 398

  Fly   432 FRTQKMLAQSSKGHSEEQNILTYRSQAAP---------------LPPPQPFFQLESEDVFKYSLM 481
            |..|.:.::.||.......:..|.:.|:.               |.|  ||:......:..||.:
  Fly   399 FGRQLIPSRISKSDLYPTQVRGYGTYASAFYIVKQNMLIVPLSLLEP--PFYTHGQPSILTYSAL 461

  Fly   482 GYIMAHHLISAFATEGIT-----IGSDGNDQSF-RSHRFEEAVSCLSRN-SENIDESMGDIAGLE 539
            |:|:.|.|...|.:||:|     :||...|:.. |:.||::.:.||.|. .....|...|.:|||
  Fly   462 GFILGHELSHGFDSEGMTFSSHGVGSSAVDRELDRNPRFQQELGCLRRRFGRKRYEKFADASGLE 526

  Fly   540 LAYFTY---AKMAKNRNRLDFTHLPPEQIFFLNVGQFFCGNSDMLV--QYKEDQVRLQRAIEGFE 599
            |||..|   |:....|||.....:..:|.||.|..||||.:.::|.  .:..|:.|:..|:..||
  Fly   527 LAYSAYFDTAQTDHKRNRSAEELVTQKQQFFHNFAQFFCSDKELLQAHDHGSDRKRVNDAVAHFE 591

  Fly   600 PFDKAFGCYRNKPKHEKCRL 619
            ||.:||.| ...|:..:|||
  Fly   592 PFREAFSC-GPSPRRRQCRL 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	148/650 (23%)
frma	NP_572226.2	GluZincin	25..601	CDD:472708	147/642 (23%)