DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl8 and Mmel1

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	738	Identity:	167/738 - (22%)
Similarity:	302/738 - (40%)	Gaps:	170/738 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ICLLLVPLVAASSNTRLLNGILSHVDKEANPCENYYNHACGQYNMRH--IDDT-----FFDIIQM 61
            ||.....::||:.       ||.::|:...||:|:|.:|||.: :||  |.:|     .|||
  Rat    84 ICTTPSCVIAAAR-------ILQNMDQSKKPCDNFYQYACGGW-LRHHVIPETNSRYSVFDI--- 137

  Fly    62 LDHQVNQNLVKLMDELE--MSSQLPDFNVS---SVDGKVLRYYLSCRG----APRNMDSLSQYLK 117
                       |.||||  :...|.|.:|.   :|: |....|.||..    ..|:.:.|...|.
  Rat   138 -----------LRDELEVILKGVLEDSSVQHRPAVE-KAKTLYRSCMNQSVIEKRDSEPLLNVLD 190

  Fly   118 VISPGEGLTWPQFIPD-----GSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMV 177
            :|.     .||..:..     |..|..|     :.||.|:......|..:|.:.::.:|:|.:::
  Rat   191 MIG-----GWPVAMDKWNETMGPKWELE-----RQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVI 245

  Fly   178 ELNTPTFG---------EES-QLPNSFIEIL-SVLYIIK----VPSSEIITLARKMRTLEL---L 224
            .::.||.|         |:| ::..::::.: ||..:::    :|....:......:.|.|   |
  Rat   246 YIDQPTLGMPSREYYFKEDSHRVREAYLQFMTSVATMLRRDLNLPGETDLVQEEMAQVLHLETHL 310

  Fly   225 LKTMI-----NPIDTLNNRYISIRDFQME---TGHNWQRFFEILIGS---SAAPELQVLVRNFRY 278
            ....:     :.:..|.:| :.:.:.|..   .|.||..|.:.::.|   ...|..:|:|....|
  Rat   311 ANATVPQEKRHDVTALYHR-MGLEELQERFGLKGFNWTLFIQNVLSSVQVELLPNEEVVVYGIPY 374

  Fly   279 FTALKELMDKQDARLVASYIMTRFAI-------------------FLLDETMGGRESTECVSQVR 324
            ...|:|::|...|:.:.:|::.|..:                   .|...||......||||.|.
  Rat   375 LENLEEIIDVFPAQTLQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTMEEVRWRECVSYVN 439

  Fly   325 RNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQ-NHLELTALQMKFFVRKAEA 388
            .||..|...||.:|.|...:.|.    :.::.||:|..|:..:|: |.::..:      .:||:.
  Rat   440 SNMESAVGSLYIKRAFSKDSKSI----VSELIEKIRSVFVDNLDELNWMDEES------KKKAQE 494

  Fly   389 IEINV---VNLPK---TDDLRHFIGQY-----YQDLQFPTGELDYH---QEHLKVLQFRTQKML- 438
            ..:|:   :..|.   .|:.||...:|     .:||.|..|..:..   |..||.|:.:..:.|
  Rat   495 KALNIREQIGYPDYILEDNNRHLDEEYSSLTFSEDLYFENGLQNLKNNAQRSLKKLREKVDQNLW 559

  Fly   439 ----AQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGIT 499
                |..:..:|..:|::.:  .|..|.|  |||..:......:..:|.::.|.:...|...|..
  Rat   560 IIGAAVVNAFYSPNRNLIVF--PAGILQP--PFFSKDQPQALNFGGIGMVIGHEITHGFDDNGRN 620

  Fly   500 IGSDGND----QSFRSHRFEEAVSCL----------SRNSENID------ESMGDIAGLELAYFT 544
            ...:||.    .:|.:..|.:...|:          ..:::|::      |::.|..|:..||..
  Rat   621 FDKNGNMLDWWSNFSARHFRQQSQCMIYQYSNFSWELADNQNVNGFSTLGENIADNGGVRQAYKA 685

  Fly   545 YAK-MAK--NRNRLDFTHLPPEQIFFLNVGQFFCGN--SDMLVQ-YKED-----QVRLQRAIEGF 598
            |.: :|:  ...||...:|...|:||:|..|.:||:  .:..:| .|.|     :.|:..:::..
  Rat   686 YLQWLAEGGRDQRLPGLNLTYAQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNL 750

  Fly   599 EPFDKAFGCYRNKPKH--EKCRL 619
            ..|.:||.|.|..|.|  .:||:
  Rat   751 PGFSEAFHCPRGSPMHPMNRCRI 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	158/707 (22%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	158/706 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910