DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl8 and Kel

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001178540.1	Gene:	Kel / 297025	RGDID:	1565470	Length:	713	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	149/728 - (20%)
Similarity:	249/728 - (34%)	Gaps:	215/728 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ICLLLVPLVAASSNTRLLNGILSHVDKEANPCENYYNHACGQYNMRHIDDTFFDIIQMLDHQVNQ 68
            :|:.||....||.|            :.|.||.::::.||.:.|  ...::|    |.|..:...
  Rat    62 VCMELVNHYLASGN------------RSAAPCTDFFSFACEKAN--GTSNSF----QALAEENKS 108

  Fly    69 NLVKLMDELEMSSQLP-DFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGLTWP--QF 130
            .|.||:       :.| .:::.|.:.|..::|.||      ||:.:    :.:.|.|   |  |.
  Rat   109 RLWKLL-------EAPGSWHLESGEEKAFQFYNSC------MDTDA----IEASGTG---PLVQI 153

  Fly   131 IPDGSSWP----------QENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVELNTPTFG 185
            |.:...|.          .:|.:.|     :.:|| ...||...:..:|......:::::.|.|.
  Rat   154 IKELGGWNISGNWTFFDFNQNLRLL-----MSQYG-HFPFFRAYLHPHPAPPHTPIIQIDQPEFD 212

  Fly   186 ---EESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTLELLLKTMINPIDTLNNRYISI----R 243
               ::.|....:.:||          .|.:|...::.||     ...||.:...:...||    |
  Rat   213 ILLQQDQEQKVYAQIL----------REYVTYLNRLGTL-----LGSNPQEAQQHASWSIVFTSR 262

  Fly   244 DFQ-------------------------METGHNWQRFFE-ILIGSSAAPELQVLVRNFRYFTAL 282
            .||                         |....:|....: |....|.:|...:.|.:..|...:
  Rat   263 LFQFLRPQQQQQAQDKLFHVVTIDALQEMAPAIDWLSCLQAIFTPMSLSPSQTLQVHDLDYLRNM 327

  Fly   283 KELMDKQDARLVASYIMTRFAIFLLDETMGGRESTECVSQVRRNMNLAANMLYKER--------- 338
            .:|:  ::..|..|.|:..:.|..|.:|:....:|: ..:.||.:......| |||
  Rat   328 SQLV--EEGLLNHSEIIQSYMILGLVDTLSPALATK-FQEARRELTQKLRKL-KERPPLPAYPRW 388

  Fly   339 ---------FFEDS--------TFSANI--------LEIKD-----------IFEKLRHQFLLQV 367
                     |||.:        .|..:|        .||||           |.|:.|.:.|.::
  Rat   389 MKCVEQTGSFFEPTLAALFVHEAFGPSIRSAAMELFAEIKDAVIVRLKKLSWISEETRKEALNKL 453

  Fly   368 DQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQF 432
            .|..:|:.|                    ||.........|.|.|:|.....|......::.||.
  Rat   454 TQLQVEMGA--------------------PKRALKTEMAKQEYSDIQLGPSFLQSFLSCVRSLQG 498

  Fly   433 RTQKMLAQSSKGHSEEQ---NILTYRS--------QAAPLPPPQPFFQLESEDVFKYSLMGYIMA 486
            |..:...|....|..::   ::..|.|        .|..|.|  |||.........:..:|.|||
  Rat   499 RKVRSFLQPFPYHRWQKSPWSVSAYYSVPDHVVVFPAGLLQP--PFFHPGYPRAVNFGAVGSIMA 561

  Fly   487 HHLISAFATEGITIGSDGNDQSFRSHRFEEAVSCLS--------------RNSENIDESMGDIAG 537
            |.|:..|....:..|....|    :...:||:.||.              ..|..:.|:..||.|
  Rat   562 HKLLHIFFQFLLPGGCPACD----TRALQEALLCLEHRYAAFPLPSMSSFNGSHTLLENAADIGG 622

  Fly   538 LELAYFTYAKMAKNRN---RLDFTHLPPEQIFFLNVGQFFCGNSDMLVQYKED-----QVRLQRA 594
            :.:|:..|.|....|.   .|....|.|.|:||.:..|..|  .:::.|..:|     ::|:...
  Rat   623 VAIAFQAYRKRITERTGELTLPNQELSPYQLFFRSYAQVMC--RELISQDPQDTHSPPRLRVHGP 685

  Fly   595 IEGFEPFDKAFGC 607
            :.....|.|.|.|
  Rat   686 LSNSPDFAKHFLC 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	143/700 (20%)
Kel	NP_001178540.1	PepO	75..713	CDD:226118	144/715 (20%)
Kel	NP_001178540.1	M13	78..711	CDD:189000	143/700 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344474
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840