Protein Alignment Nepl8 and Mmel1

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_038811.2
• Gene: Mmel1 / 27390
• MGIID: 1351603
• Length: 766
• Species: Mus musculus
• Alignment Length: 747
• Identity: 168/747 - (22%)
• Similarity: 303/747 - (40%)
• Gaps: 187/747 - (25%)

  Fly     4 ICLLLVPLVAASSNTRLLNGILSHVDKEANPCENYYNHACGQYNMRH--IDDT-----FFDIIQM 61
            ||.....::||:.       ||.::|:..|||||:|.:|||.: :||  |.:|     .|||
Mouse    75 ICTTPSCVIAAAR-------ILENMDQSRNPCENFYQYACGGW-LRHHVIPETNSRYSVFDI--- 128

  Fly    62 LDHQVNQNLVKLMDELE--MSSQLPDFNVS---SVDGKVLRYYLSCRG----APRNMDSLSQYLK 117
                       |.||||  :...|.|....   :|: |....|.||..    ..|:.:.|...||
Mouse   129 -----------LRDELEVILKGVLEDSTSQHRPAVE-KAKTLYRSCMNQSVIEKRDSEPLLSVLK 181

  Fly   118 VISPGEGLTWPQFIPDGSSWPQE-NFKW--LKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVEL 179
            ::.     .||..:   ..|.:. ..||  .:.||.|:......|..:|.:.::.:|:|.:::.:
Mouse   182 MVG-----GWPVAM---DKWNETMGLKWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYI 238

  Fly   180 NTPTFGEES-----------QLPNSFIEILSVLYIIKVPSSEIITLARKMRTLE----------- 222
            :.||.|..|           ::..:::|.:          :.:.|:.||.:.|.
Mouse   239 DQPTLGMPSREYYFQEDNNHKVRKAYLEFM----------TSVATMLRKDQNLSKESAMVREEMA 293

  Fly   223 --LLLKTMI----------NPIDTLNNRYISIRDFQME---TGHNWQRFFEILIGS---SAAPEL 269
              |.|:|.:          :.:..|.:| :.:.:.|..   .|.||..|.:.::.|   ...|:.
Mouse   294 EVLELETHLANATVPQEKRHDVTALYHR-MDLMELQERFGLKGFNWTLFIQNVLSSVEVELFPDE 357

  Fly   270 QVLVRNFRYFTALKELMDKQDARLVASYIMTRFAI-------------------FLLDETMGGRE 315
            :|:|....|...|::::|...||.:.:|::.|..:                   .|...|:....
Mouse   358 EVVVYGIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVR 422

  Fly   316 STECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQ-NHLELTALQM 379
            ..||||.|..||..|...||.:|.|...:.|.    ::::.||:|..|:..:|: |.::..:
Mouse   423 WRECVSYVNSNMESAVGSLYIKRAFSKDSKST----VRELIEKIRSVFVDNLDELNWMDEES--- 480

  Fly   380 KFFVRKAEAIEINV---VNLPK---TDDLRHFIGQY-----YQDLQFPTGELDYH---QEHLKVL 430
               .:||:...:|:   :..|.   .|:.:|...:|     |:||.|..|..:..   |..||.|
Mouse   481 ---KKKAQEKAMNIREQIGYPDYILEDNNKHLDEEYSSLTFYEDLYFENGLQNLKNNAQRSLKKL 542

  Fly   431 QFRTQKML-----AQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLI 490
            :.:..:.|     |..:..:|..:|.:.:  .|..|.|  |||..:......:..:|.::.|.:.
Mouse   543 REKVDQNLWIIGAAVVNAFYSPNRNQIVF--PAGILQP--PFFSKDQPQSLNFGGIGMVIGHEIT 603

  Fly   491 SAFATEGITIGSDGND----QSFRSHRFEEAVSCL----------SRNSENID------ESMGDI 535
            ..|...|.....:||.    .:|.:..|::...|:          ..:::|::      |::.|.
Mouse   604 HGFDDNGRNFDKNGNMLDWWSNFSARHFQQQSQCMIYQYGNFSWELADNQNVNGFSTLGENIADN 668

  Fly   536 AGLELAYFTYAKMAKN---RNRLDFTHLPPEQIFFLNVGQFFCGN--SDMLVQ-YKED-----QV 589
            .|:..||..|.:...:   ..||...:|...|:||:|..|.:||:  .:..|| .|.|     :.
Mouse   669 GGVRQAYKAYLRWLADGGKDQRLPGLNLTYAQLFFINYAQVWCGSYRPEFAVQSIKTDVHSPLKY 733

  Fly   590 RLQRAIEGFEPFDKAFGCYRNKPKH--EKCRL 619
            |:..:::....|.:||.|.|..|.|  ::||:
Mouse   734 RVLGSLQNLPGFSEAFHCPRGSPMHPMKRCRI 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	159/716 (22%)
Mmel1	NP_038811.2	M13	97..764	CDD:341056	159/715 (22%)