Protein Alignment Nepl8 and Phex

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_037136.2
• Gene: Phex / 25512
• RGDID: 3323
• Length: 749
• Species: Rattus norvegicus
• Alignment Length: 724
• Identity: 145/724 - (20%)
• Similarity: 269/724 - (37%)
• Gaps: 169/724 - (23%)

  Fly    24 ILSHVDKEANPCENYYNHACGQY---NMRHIDDTFFDIIQMLDHQVNQNLVKLMD---------- 75
            |:|.|:...:||||::..||..:   |....|...:.:...|.|.|:..|..|::
  Rat    66 IMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTE 130

  Fly    76 -----ELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGLTWP----QFI 131
                 ::..||.:.:..:...|.|.|.:.|  |.:|                  ..||    ...
  Rat   131 AVQKAKILYSSCMNEKAIEKADAKPLLHIL--RHSP------------------FRWPVLEANIG 175

  Fly   132 PDGSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVELNTPTFG---EESQLPNS 193
            |:| .|.:..|..|:.||........:||..|.|..:.:.::|::::|:..|..   .|..|.|:
  Rat   176 PEG-VWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNT 239

  Fly   194 FIEILS---VLYIIKVPSSEII-------------TLARKMRTLELLLKTMINPIDTLNNRYISI 242
             .|..|   .||...|.::.::             .|..:::..|:::.......:.:.|: ::|
  Rat   240 -TEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNK-MNI 302

  Fly   243 RDFQ-METGHNWQRFFEILIGSSAAPELQ-------VLVRNFRYFTALKELMDKQDARLVASYIM 299
            .:.. |....:|..:.:.:|.:...|.|:       |:||..:||..|..::..:..:.:|:|::
  Rat   303 SELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANYLV 367

  Fly   300 TR-------------------FAIFLLDETMGGRESTECVSQVRRNMNLAANMLYKERFFEDSTF 345
            .|                   |:..:...|....:..:||:.:...:......::....|::.
  Rat   368 WRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQED-- 430

  Fly   346 SANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYY 410
            ...::|  ::.|.:|..|:..:::.:..:.|...:....||.|: :..|..|:......::.:..
  Rat   431 KKEMME--ELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAV-LAKVGYPEFIMNDTYVNEDL 492

  Fly   411 QDLQFPTGELDYHQEHLKVLQFRTQKMLAQS---------------------SKGHSEEQNILTY 454
            :.::|  .|.||..   .|||  |:|.||||                     :..:|...|.:
  Rat   493 KAIKF--SESDYFG---NVLQ--TRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQI-- 548

  Fly   455 RSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGNDQSFRS----HRFE 515
            |..|..|..|. |:..|......|..:|.|:.|.....|...|.....:||...:.|    .:|:
  Rat   549 RFPAGELQKPF-FWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVDSEEKFK 612

  Fly   516 EAVSCLSRNSEN---------------IDESMGDIAGLELAYFTYAKMAKNRNR---------LD 556
            |...|:.....|               :.|::.|..||..|:..|.|...:|.:         :.
  Rat   613 EKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLLPGIT 677

  Fly   557 FTHLPPEQIFFLNVGQFFCGN--------SDMLVQYKEDQVRLQRAIEGFEPFDKAFGCYRNKPK 613
            ||:   .|:|||:.....|.:        ...:..:...|.|:..||..||.|.|||.|..|...
  Rat   678 FTN---NQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPANSTM 739

  Fly   614 H---EKCRL 619
            :   :.|||
  Rat   740 NRGADSCRL 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	139/713 (19%)
Phex	NP_037136.2	M13	74..740	CDD:341056	139/706 (20%)