Protein Alignment Nepl8 and Mme

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_036740.1
• Gene: Mme / 24590
• RGDID: 3098
• Length: 750
• Species: Rattus norvegicus
• Alignment Length: 770
• Identity: 173/770 - (22%)
• Similarity: 296/770 - (38%)
• Gaps: 213/770 - (27%)

  Fly     3 IICLLLVPLVA--------ASSNTRLLNGILSHVDKEANPCENYYNHACGQYNMRH-IDDTF--- 55
            ||.:.::.|.|        :|...:....::.::|..|.||.:::.:|||.:..|: |.:|.
  Rat    40 IIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRY 104

  Fly    56 --FDIIQMLDHQVNQNLVKLMDELEMSSQLPDF-------NVSSVDGKVLRYYLSC--------R 103
              |||              |.||||:.  |.|.       ::.:|. |....|.||        |
  Rat   105 SNFDI--------------LRDELEVI--LKDVLQEPKTEDIVAVQ-KAKTLYRSCINESAIDSR 152

  Fly   104 GAPRNMDSLSQYLKVISPGEGLTWPQFIPD-----GSSWPQENFKWLKALAHLH-RYGLTNVFFN 162
            |        .|.|..:.| :...||....:     |:||..|     |::|.|: :|| ..|..|
  Rat   153 G--------GQPLLTLLP-DIYGWPVASQNWEQTYGTSWTAE-----KSIAQLNSKYG-KKVLIN 202

  Fly   163 LEVVSNPRNASEYMVELNTPTFGEESQLPN---------------SFIE-ILSVLYII----KVP 207
            ..|.::.:|::::::..:.|..|    ||:               :::: ::||..:|    ::|
  Rat   203 FFVGTDDKNSTQHIIHFDQPRLG----LPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLP 263

  Fly   208 SSEIITLARKMRTLELLLKTMIN----PID-----TLNNRYISIR---DFQMETG---HNWQRFF 257
            ..| ..|:.:|..:..|.|.:.|    |.|     .|.|:....:   :|.:|..   .:|..|.
  Rat   264 IDE-NQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFT 327

  Fly   258 -EIL--IGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLD----------- 308
             ||:  :..:...|.:|:|....|.|.||.::.|...|.:.:.:..||.:.|:.
  Rat   328 NEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRN 392

  Fly   309 ---ETMGGRES-----TECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLL 365
               :.:.|..|     ..|.:.|..||..|...||.|..|...  |.:::|  |:..::|..|:.
  Rat   393 AFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGE--SKHVVE--DLIAQIREVFIQ 453

  Fly   366 QVDQNHLELT---ALQMKFFVRKAEAIEINVVNLPKTDDL---RHFIGQYYQDLQFPTGELDYHQ 424
            .:|    :||   |...|....||.||: ..:..|  ||:   .:.:...|.:|.:.  |.:|.:
  Rat   454 TLD----DLTWMDAETKKKAEEKALAIK-ERIGYP--DDIISNENKLNNEYLELNYK--EEEYFE 509

  Fly   425 EHLKVLQFRTQKML----------------AQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESE 473
            ..::.|:|...|.|                |..:..:|..:|.:.:  .|..|.|  |||.....
  Rat   510 NIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVF--PAGILQP--PFFSARQS 570

  Fly   474 DVFKYSLMGYIMAHHLISAFATEGITIGSDGN------DQSFRSHRFEEAVSCLSRNSEN----- 527
            :...|..:|.::.|.:...|...|.....||:      .||  ::.|::...|:.....|
  Rat   571 NSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQS--ANNFKDQSQCMVYQYGNFTWDL 633

  Fly   528 -----------IDESMGDIAGLELAYFTYAKMAKNRNR------LDFTHLPPEQIFFLNVGQFFC 575
                       :.|::.|..|:..||..|....|....      ||..|   :|:||||..|.:|
  Rat   634 AGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNH---KQLFFLNFAQVWC 695

  Fly   576 G--------NSDMLVQYKEDQVRLQRAIEGFEPFDKAFGCYRN---KPKHEKCRL 619
            |        ||.....:.....|:...::....|..||.|.:|   .|: .|||:
  Rat   696 GTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPE-RKCRV 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	165/730 (23%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	164/728 (23%)