Protein Alignment Nepl8 and Kel

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_115929.3
• Gene: Kel / 23925
• MGIID: 1346053
• Length: 713
• Species: Mus musculus
• Alignment Length: 759
• Identity: 150/759 - (19%)
• Similarity: 260/759 - (34%)
• Gaps: 215/759 - (28%)

  Fly     2 WI-ICLLLVPLVAASSN-------------------TRLLNGILSHVDKEANPCENYYNHACGQY 46
            |: :.:||..|:..||.                   ..||:..|:..::...||.::::.||.:.
Mouse    28 WVLLAVLLCGLLLGSSMLWFYIFRNCGPCPCETPVCMELLDHYLASGNRSVAPCTDFFSFACEKA 92

  Fly    47 NMRHIDDTFFDIIQMLDHQVNQNLVKLMDELEMSSQLP-DFNVSSVDGKVLRYYLSCRGAPRNMD 110
            |  ...|:|    |.|..:....|.:|:       :.| .:::.|.:.|..::|.||      ||
Mouse    93 N--GTSDSF----QALTEENKSRLWRLL-------EAPGSWHLGSGEEKAFQFYNSC------MD 138

  Fly   111 SLSQYLKVISPGEGLTWP--QFIPDGSSWP----------QENFKWLKALAHLHRYGLTNVFFNL 163
            :.:    :.:.|.|   |  |.|.:...|.          .:|.:.|     :.:|| ...||..
Mouse   139 TDA----IEASGSG---PLIQIIEELGGWNITGNWTSLDFNQNLRLL-----MSQYG-HFPFFRA 190

  Fly   164 EVVSNPRNASEYMVELNTPTFG---EESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTLELLL 225
            .:..:|......:::::.|.|.   ::.|....:.:||          .|.:|...::.||
Mouse   191 YLRPHPAPPHTPIIQIDQPEFDILLQQEQEQKVYAQIL----------REYVTYLNRLGTL---- 241

  Fly   226 KTMINPIDTLNNRYISI----RDFQMETGHNWQRFFEILIGSSAAPELQ---------------- 270
             ...||.:...:...||    |.||.......|:..:.|.......|||
Mouse   242 -LGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDELQEMAPAIDWLSCLQAIF 305

  Fly   271 ----------VLVRNFRYFTALKELMDK---QDARLVASYIM------------TRFAIF---LL 307
                      ::|.:..|...:.:|:::   .....:.||::            |:|...   |:
Mouse   306 TPMSLNSSQTLVVHDLDYLRNMSQLVEEGLLNHRESIQSYMILGLVDTLSPALDTKFQEARRELI 370

  Fly   308 DETMGGRES---------TECVSQVRRNMNLAANMLYKERFFEDSTFSANI---LEIKD------ 354
            .|....:|.         .:||.|...........|:....|..|..||.:   .||||
Mouse   371 QELRKLKERPPLPAYPRWMKCVEQTGAFFEPTLAALFVREAFGPSIQSAAMELFAEIKDAVIIRL 435

  Fly   355 -----IFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQ 414
                 |.|:.:.:.|.::.|..:|:.|                    ||.........|.|.|:|
Mouse   436 KKLSWISEETQKEALNKLAQLQVEMGA--------------------PKRAVKPDIATQEYNDIQ 480

  Fly   415 FPTGELDYHQEHLKVLQFRTQKMLAQSSKGHSEEQN---ILTYRS--------QAAPLPPPQPFF 468
            .....|......::.|:.|..:...|....|..:::   :..|.|        .|..|.|  |||
Mouse   481 LGPSFLQSFLSCVRSLRARNVQSFLQPFPYHRWQKSPWEVNAYYSISDHMVVFPAGLLQP--PFF 543

  Fly   469 QLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGNDQSFRSHRFEEAVSCLSRN--------- 524
            .........:...|.||||.|:..|....:..|....|    :|..:||:.||.|:
Mouse   544 HPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCPACD----THVLQEALLCLERHYAAFPLPSI 604

  Fly   525 -----SENIDESMGDIAGLELAYFTYAK-MAKNRNRLDFTH--LPPEQIFFLNVGQFFC---GNS 578
                 |..:.|:..||.|:.:|:..|:| :.::...|...:  |.|.|:||.:..|..|   .:.
Mouse   605 SSFNGSHTLLENAADIGGVAIAFQAYSKRIVEHTGELTLPNLDLSPYQLFFRSYAQVMCRGLSSQ 669

  Fly   579 DMLVQYKEDQVRLQRAIEGFEPFDKAFGCYRN---KPKHEKCRL 619
            |....:....:|:...:.....|.|.|.|.|.   .|. .:|:|
Mouse   670 DPQDPHSPPSLRVHGPLSNTPDFAKHFHCPRGTLLNPS-ARCKL 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	139/706 (20%)
Kel	NP_115929.3	M13	78..711	CDD:341056	139/706 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840