Protein Alignment Nepl8 and nep-25

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_495164.2
• Gene: nep-25 / 191543
• WormBaseID: WBGene00022874
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 690
• Identity: 118/690 - (17%)
• Similarity: 201/690 - (29%)
• Gaps: 317/690 - (45%)

  Fly    24 ILSHVDKEANPCENYYNHAC--------------------GQYNMRHID-DTF-----FDIIQML 62
            |..|.|...:||.::|.|.|                    .:|..:|.. |.|     |.|.:.|
 Worm    32 IKKHADFSVDPCVDFYAHVCPWKVERYFMEDLSKLKAGMVAKYRKKHPKFDKFKGEDAFAIAEAL 96

  Fly    63 DHQVNQNLVKLMDELEMSS-QLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGLT 126
            .   ..|:.:|..|.:.|. :|..|.:|:.|.:.:          .|:|      :|:.||
 Worm    97 K---QLNIEQLKSECKPSKPRLSSFFISAQDNRTI----------ENVD------EVLFPG---- 138

  Fly   127 WPQFIPDGSSWPQENFKW-------LKALAHLHRYGLTNVFFNLEVVSNPRN---ASEYMVELNT 181
                        .||:..       :|.:..:..|..|.     .|:.:..|   .|:.:.:|:.
 Worm   139 ------------FENYPCEEKAAIIIKEVGEIEDYTTTR-----SVLVSAVNGFITSKLVEKLDV 186

  Fly   182 PTFGEESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTLELLLKTMINPIDTLNNRYISIRDFQ 246
                :..:|.|.|..::| ..|||.|      .|:..:.:|..::.:.|         |:.|.|.
 Worm   187 ----KARKLFNKFKSVIS-KEIIKTP------WAKNYKAIEQYVEALSN---------ITFRTFA 231

  Fly   247 METGHNWQRFFEILIGSSAAPELQVLVRNFRYFTALKELMDKQD-------ARLVASYIMTRFAI 304
                       ::.|....:.||        |.:..|:...|.|       |.||...:.||.|.
 Worm   232 -----------DVRITVKKSMEL--------YESTEKDCRKKLDVAFSQPTAELVCKGVATRKAE 277

  Fly   305 FLLDETMGGRESTECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEK---------LR 360
            .||||.:                        ::.|.:|   .|.||  ||:::.         :.
 Worm   278 ELLDEPI------------------------EDIFPQD---QAGIL--KDVWQMFNSFDNSVYIG 313

  Fly   361 HQFLLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQE 425
            ::|||                              |..||        |:.||
 Worm   314 NEFLL------------------------------LLNTD--------YFSDL------------ 328

  Fly   426 HLKVLQFRTQKMLAQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLI 490
                                                                |..:|:.|.|.::
 Worm   329 ----------------------------------------------------YGSIGFSMIHEIM 341

  Fly   491 SAFATEGITIGSDGN------------------DQSFRS----------HRFEEAVSCLSRNSEN 527
            .       |:..|.|                  ||:.::          |..:.|.:    .:..
 Worm   342 H-------TLVFDDNDLDKPLSKLWTKNADCVKDQALKTCETFPTVTEMHNMKPACN----TTVT 395

  Fly   528 IDESMGDIAGLELAYFTYAKMAKNRNRL-DFTHLPPEQIFFLNVGQFFCGNSDML------VQYK 585
            .:|...|:|...:|:..|......:..: ::..|..:|:||.....|||....|.      :.:.
 Worm   396 FEEDAADLAAYRIAWRIYENSYARKTVVPNYEALDKKQLFFYGAAVFFCNQDGMSRVPFQNLAHS 460

  Fly   586 EDQVRLQRAIEGFEPFDKAFGC------YRNKPKHEKCRL 619
            .:..|:...:...:.|..||.|      ..|:.||  |.|
 Worm   461 NNYQRVNSLMSQMKQFSDAFKCKPTDKMITNRAKH--CEL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	113/679 (17%)
nep-25	NP_495164.2	Peptidase_M13	308..496	CDD:279739	41/302 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000