DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nepl8 and ECE1

DIOPT Version :9

Sequence 1:NP_609795.2 Gene:Nepl8 / 34983 FlyBaseID:FBgn0032585 Length:619 Species:Drosophila melanogaster
Sequence 2:XP_011539174.1 Gene:ECE1 / 1889 HGNCID:3146 Length:778 Species:Homo sapiens


Alignment Length:765 Identity:161/765 - (21%)
Similarity:275/765 - (35%) Gaps:215/765 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 IICLLLVPLVAASS------NTR------------LLNGILSHVDKEANPCENYYNHACGQY-NM 48
            ::.||...|||..:      .||            :.:.|||.:|...:||.:::::|||.: ..
Human    80 LVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA 144

  Fly    49 RHIDD------TFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPR 107
            ..:.|      ||.:   :.:|  ||.::|.:  ||.|:.    :||..:.|...||.:|....|
Human   145 NPVPDGHSRWGTFSN---LWEH--NQAIIKHL--LENSTA----SVSEAERKAQVYYRACMNETR 198

  Fly   108 ----NMDSLSQYLKVISPGEGLTWPQFIPDGSSWPQENFK-WLKALAHLHRYGLTNVFFNLEVVS 167
                ....|.:.::.:. |..:|.|        |.::||: .|:.:...:|   |:.||::.|.:
Human   199 IEELRAKPLMELIERLG-GWNITGP--------WAKDNFQDTLQVVTAHYR---TSPFFSVYVSA 251

  Fly   168 NPRNAS---------------------------------EYMVELNTPTFG--EESQLP--NSFI 195
            :.:|::                                 .|||:|.....|  ||:..|  ...:
Human   252 DSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQIL 316

  Fly   196 EILSVLYIIKVPSSEIITLARKMRTLELLLKTMINPIDTLNNRYISIRDFQMET---GHNWQRFF 257
            :..:.|..|.:|.       .|.|..||:              |..:...:::|   ..||..|.
Human   317 DFETALANITIPQ-------EKRRDEELI--------------YHKVTAAELQTLAPAINWLPFL 360

  Fly   258 EILIGSSAAPELQ-VLVRNFRYFTALKELMDKQDARLVASYI---MTRFAIFLLD---------- 308
            ..:.......|.: ::|.:..|...:..|::..|..|:.:|:   :.|.....||          
Human   361 NTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKF 425

  Fly   309 -ETMGGREST------ECVSQVRRNMNLAAN-MLYKERFFEDSTFSAN--ILEIKDIFEKLRHQF 363
             |.|.|.:.|      .|||....|:..|.. |..|..|.|||...|.  |||||..||:     
Human   426 MEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEE----- 485

  Fly   364 LLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELD------- 421
                     .|:.|:......:..|.|       |.|.:.:.||  |.:......|||       
Human   486 ---------SLSTLKWMDEETRKSAKE-------KADAIYNMIG--YPNFIMDPKELDKVFNDYT 532

  Fly   422 -----YHQEHLKVLQFRTQKMLAQSSKGHSEEQNILTYRSQAAPLPPPQ------------PFFQ 469
                 |.:..::...|..:....|..|..:.:|..:|.....|...|.:            ||:.
Human   533 AVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYT 597

  Fly   470 LESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGNDQSFRSH----RFEEAVSCL-------SR 523
            ..|.....:..:|.::.|.|..||..:|.....|||.:.:..:    .|:....|:       |.
Human   598 RSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSV 662

  Fly   524 NSENID------ESMGDIAGLELAYFTYAKMAKN---RNRLDFTHLPPEQIFFLNVGQFFC---- 575
            |.|.::      |::.|..||:.||..|....|.   .:.|....|...|:|||...|.:|    
Human   663 NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRT 727

  Fly   576 --GNSDMLV--QYKEDQVRLQRAIEGFEPFDKAFGCYRNKPKH--EKCRL 619
              .:.:.|:  .:...:.|:..::...:.|.:.|.|....|.:  .||.:
Human   728 PESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEV 777

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nepl8NP_609795.2 GluZincin 32..618 CDD:301352 149/715 (21%)
ECE1XP_011539174.1 PepO 114..769 CDD:226118 151/721 (21%)
M13 127..776 CDD:189000 149/715 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3590
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11733
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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