Protein Alignment Nepl8 and ECE1

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 765
• Identity: 161/765 - (21%)
• Similarity: 275/765 - (35%)
• Gaps: 215/765 - (28%)

  Fly     3 IICLLLVPLVAASS------NTR------------LLNGILSHVDKEANPCENYYNHACGQY-NM 48
            ::.||...|||..:      .||            :.:.|||.:|...:||.:::::|||.: ..
Human    80 LVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA 144

  Fly    49 RHIDD------TFFDIIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPR 107
            ..:.|      ||.:   :.:|  ||.::|.:  ||.|:.    :||..:.|...||.:|....|
Human   145 NPVPDGHSRWGTFSN---LWEH--NQAIIKHL--LENSTA----SVSEAERKAQVYYRACMNETR 198

  Fly   108 ----NMDSLSQYLKVISPGEGLTWPQFIPDGSSWPQENFK-WLKALAHLHRYGLTNVFFNLEVVS 167
                ....|.:.::.:. |..:|.|        |.::||: .|:.:...:|   |:.||::.|.:
Human   199 IEELRAKPLMELIERLG-GWNITGP--------WAKDNFQDTLQVVTAHYR---TSPFFSVYVSA 251

  Fly   168 NPRNAS---------------------------------EYMVELNTPTFG--EESQLP--NSFI 195
            :.:|::                                 .|||:|.....|  ||:..|  ...:
Human   252 DSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQIL 316

  Fly   196 EILSVLYIIKVPSSEIITLARKMRTLELLLKTMINPIDTLNNRYISIRDFQMET---GHNWQRFF 257
            :..:.|..|.:|.       .|.|..||:              |..:...:::|   ..||..|.
Human   317 DFETALANITIPQ-------EKRRDEELI--------------YHKVTAAELQTLAPAINWLPFL 360

  Fly   258 EILIGSSAAPELQ-VLVRNFRYFTALKELMDKQDARLVASYI---MTRFAIFLLD---------- 308
            ..:.......|.: ::|.:..|...:..|::..|..|:.:|:   :.|.....||
Human   361 NTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKF 425

  Fly   309 -ETMGGREST------ECVSQVRRNMNLAAN-MLYKERFFEDSTFSAN--ILEIKDIFEKLRHQF 363
             |.|.|.:.|      .|||....|:..|.. |..|..|.|||...|.  |||||..||:
Human   426 MEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEE----- 485

  Fly   364 LLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELD------- 421
                     .|:.|:......:..|.|       |.|.:.:.||  |.:......|||
Human   486 ---------SLSTLKWMDEETRKSAKE-------KADAIYNMIG--YPNFIMDPKELDKVFNDYT 532

  Fly   422 -----YHQEHLKVLQFRTQKMLAQSSKGHSEEQNILTYRSQAAPLPPPQ------------PFFQ 469
                 |.:..::...|..:....|..|..:.:|..:|.....|...|.:            ||:.
Human   533 AVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYT 597

  Fly   470 LESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGNDQSFRSH----RFEEAVSCL-------SR 523
            ..|.....:..:|.::.|.|..||..:|.....|||.:.:..:    .|:....|:       |.
Human   598 RSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSV 662

  Fly   524 NSENID------ESMGDIAGLELAYFTYAKMAKN---RNRLDFTHLPPEQIFFLNVGQFFC---- 575
            |.|.::      |::.|..||:.||..|....|.   .:.|....|...|:|||...|.:|
Human   663 NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRT 727

  Fly   576 --GNSDMLV--QYKEDQVRLQRAIEGFEPFDKAFGCYRNKPKH--EKCRL 619
              .:.:.|:  .:...:.|:..::...:.|.:.|.|....|.:  .||.:
Human   728 PESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEV 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	149/715 (21%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	149/715 (21%)