Protein Alignment Nepl8 and nep-18

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 744
• Identity: 150/744 - (20%)
• Similarity: 271/744 - (36%)
• Gaps: 224/744 - (30%)

  Fly    23 GILSHVDKEAN----PCENYYNHACGQYNMRHIDDTFFDIIQ--MLDHQV--------------N 67
            |:|:.:....|    |||:::.|.||:|:...:||..:..:|  .|.:||              |
 Worm    34 GVLAMIKNYQNASVDPCEDFFEHTCGRYSEHVMDDNSWGYVQYKQLLYQVFAIARKTNKFNSKPN 98

  Fly    68 QNL----VKLMDELEMSSQL------------------PDFNVSSVD-GKVLRYYLSCRGAPRNM 109
            :.|    ...:|..||....                  |::|....| ..:|..|||........
 Worm    99 EQLRIFTKSCLDRKEMDEDTFQDLRNDIEERGGFPMIDPNWNEEKFDLSDMLAKYLSINRNRMGF 163

  Fly   110 DSLSQYLKV----------ISPGEGLTWPQFIPDGSSWPQENFKWLKALAHLHRYGLTNVFFNLE 164
            .|:..|..:          :|||     |.::          :.|...:: :::   .:|.|.|.
 Worm   164 LSVEPYAAIEGNKSVNRLYVSPG-----PHWV----------YNWAMGIS-IYK---DSVAFMLR 209

  Fly   165 VVSNPRNASEYMVELNTPTFGEESQLPNSFIEILSVLYIIKVPSSEIITLA------------RK 217
            .:....|.     |||...:.:|      |.|::.:       .:...|||            .|
 Worm   210 RLLKLENR-----ELNETIYDKE------FAELVQL-------EANFSTLADYRNLALDNDNMSK 256

  Fly   218 MRTLELLLKTMINPIDTLNNRYISIRDFQMETGHNWQRFFEILI--GSSAAPELQVLVR------ 274
            .|.|..|:| ||..||                   |.:..:.|.  |:|...|.::|.|
 Worm   257 SRNLTDLVK-MIPEID-------------------WIKILKALARHGTSEEDEEKLLERVTVHGA 301

  Fly   275 NFRYFTALKELMDKQDARL--------VASYIMTR----FAIFLLDETMGGR--------ESTEC 319
            ...:|...:||     ||:        :|:|::.|    .|::..|:....:        :.:.|
 Worm   302 GEYFFGENREL-----ARIATETPKSALANYLVVRQLIDVALYFYDKDQPRQNKFYNHVDQQSFC 361

  Fly   320 VSQVRR-----NMNLAANMLYKERFFEDSTFS-ANILEIKDIFEKLRHQF-LLQVDQNHLELTAL 377
            .:||..     :||:         |.|.|.|. .|:..|:::|.|::.:: .:..:..:|||..
 Worm   362 ATQVASFFPMPSMNV---------FIESSQFKIENLKVIEEMFVKIKAEYEQIFTENEYLELEI- 416

  Fly   378 QMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKMLAQSS 442
             .:|.:||..||: ....|.:..:.:..:.:.|:.|.|...:..: |.::|:.:..:::::....
 Worm   417 -REFLIRKLNAID-GKFGLDQYTEGKPLLEKMYETLNFLDTDSPW-QVYMKMWRHWSEQLVEHIV 478

  Fly   443 KGHS---EEQNILTYRSQAAPLPPPQ-----------PFFQLESEDVFKYSLMGYIMAHHLISAF 493
              |.   :..|:..:.:.||..|.|.           |:...:......|..:||::.|.:..||
 Worm   479 --HDTPLDPVNLKMFGTHAAYQPYPNHFYINLPYLTYPWMDADFPANTNYGYLGYVIGHEIGHAF 541

  Fly   494 ATEGITIGSDGNDQSF-------RSHRFEEAVSCL-----SRNSENID----------ESMGDIA 536
            ......:...|..|.:       .:..:|....||     :......|          |..||..
 Worm   542 DHFHRKLDESGRQQQYWFTETNSSNTEYELREKCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHM 606

  Fly   537 GLELAYFTYAKMAK-NRNRLDFTHLPPEQIFFLNVGQFFCG-------NSDMLV-QYKEDQVRLQ 592
            |:..|:..:.|:.| :|.||....:..||:||.|.....|.       ..:||. |:..::.|:.
 Worm   607 GIRTAFRVFEKVKKEDRFRLPGLEMSEEQLFFYNYAFRQCDVYNPNKLPRNMLARQHPTNRYRVN 671

  Fly   593 RAIEGFEPFDKAFGCYRNKPKHE--KCRL 619
            ..|:....|.:||.|.:|.|.:.  ||:|
 Worm   672 GVIQNIPEFAEAFNCPKNSPMNPEMKCKL 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	146/732 (20%)
nep-18	NP_494297.1	M13	47..699	CDD:341056	145/728 (20%)