DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl8 and Phex

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_035207.1	Gene:	Phex / 18675	MGIID:	107489	Length:	749	Species:	Mus musculus

Alignment Length:	724	Identity:	146/724 - (20%)
Similarity:	270/724 - (37%)	Gaps:	169/724 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ILSHVDKEANPCENYYNHACGQY---NMRHIDDTFFDIIQMLDHQVNQNLVKLMD---------- 75
            |:|.|:...:||||::..||..:   |....|...:.:...|.|.|:..|..|::
Mouse    66 IMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTE 130

  Fly    76 -----ELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGLTWP----QFI 131
                 ::..||.:.:..:...|.|.|.:.|  |.:|                  ..||    ...
Mouse   131 AVQKAKILYSSCMNEKAIEKADAKPLLHIL--RHSP------------------FRWPVLEANIG 175

  Fly   132 PDGSSWPQENFKWLKALAHLHRYGLTNVFFNLEVVSNPRNASEYMVELNTPTFG---EESQLPNS 193
            |:| .|.:..|..|:.||........:||..|.|..:.:.::|::::|:..|..   .|..|.|:
Mouse   176 PEG-VWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNT 239

  Fly   194 FIEILS---VLYIIKVPSSEII-------------TLARKMRTLELLLKTMINPIDTLNNRYISI 242
             .|..|   .||...|.::.::             .|..:::..|:::.......:.:.|: ::|
Mouse   240 -TEAKSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNK-MNI 302

  Fly   243 RDFQ-METGHNWQRFFEILIGSSAAPELQ-------VLVRNFRYFTALKELMDKQDARLVASYIM 299
            .:.. |....:|..:.:.:|.:...|.|:       |:||..:||..|..::..:..:.:|:|::
Mouse   303 SELSAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVVRVPQYFKDLFRILGAERKKTIANYLV 367

  Fly   300 TR-------------------FAIFLLDETMGGRESTECVSQVRRNMNLAANMLYKERFFEDSTF 345
            .|                   |:..:...|....:..:||:.:...:......::....|::.
Mouse   368 WRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQED-- 430

  Fly   346 SANILEIKDIFEKLRHQFLLQVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYY 410
            ...::|  ::.|.:|..|:..:::.:..:.|...:....||.|: :..|..|:......::.:..
Mouse   431 KKEMME--ELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAV-LAKVGYPEFIMNDTYVNEDL 492

  Fly   411 QDLQFPTGELDYHQEHLKVLQFRTQKMLAQS---------------------SKGHSEEQNILTY 454
            :.::|  .|.||..   .|||  |:|.||||                     :..:|...|.:
Mouse   493 KAIKF--SESDYFG---NVLQ--TRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQI-- 548

  Fly   455 RSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGNDQSFRS----HRFE 515
            |..|..|..|. |:..|......|..:|.|:.|.....|...|.....:||...:.|    .:|:
Mouse   549 RFPAGELQKPF-FWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVESEEKFK 612

  Fly   516 EAVSCLSRNSEN---------------IDESMGDIAGLELAYFTYAKMAKNRNR---------LD 556
            |...|:.....|               :.|::.|..||..|:..|.|...:|.:         :.
Mouse   613 EKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPLLPGIT 677

  Fly   557 FTHLPPEQIFFLNVGQFFCGN--------SDMLVQYKEDQVRLQRAIEGFEPFDKAFGCYRNKPK 613
            ||:   .|:|||:.....|.:        ...:..:...|.|:..||..||.|.|||.|.||...
Mouse   678 FTN---NQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPRNSTM 739

  Fly   614 H---EKCRL 619
            :   :.|||
Mouse   740 NRGADSCRL 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	140/713 (20%)
Phex	NP_035207.1	PepO	67..741	CDD:226118	142/714 (20%)
Phex	NP_035207.1	M13	74..747	CDD:189000	140/713 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910