Protein Alignment Nepl8 and nep-8

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001309548.1
• Gene: nep-8 / 184631
• WormBaseID: WBGene00017553
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 677
• Identity: 136/677 - (20%)
• Similarity: 258/677 - (38%)
• Gaps: 163/677 - (24%)

  Fly    20 LLNGILSHVDKEANPCENYYNHACGQYNMRHIDDTFF---------DIIQMLDHQV------NQN 69
            |.:.:|::.|...:||.:::.|:||:::.:.:.::..         .|.:.| |::      ::|
 Worm    64 LSHELLNYQDPSVDPCVDFFQHSCGRFHEQSVSESRLQKKKHILRKQIREFL-HKIQNSTSKSEN 127

  Fly    70 LVKLM-DELEMSSQLPDFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGLTWPQFIPD 133
            |:||: |:.|.|.:..:.|           |...|.|   :..:...:|.|.     .||..
 Worm   128 LMKLVFDKCEASKKTSNDN-----------YKISRDA---IHDVFNDIKKIG-----AWPLL--- 170

  Fly   134 GSSWPQENFKWLKALAHLHRYGLTNV-FFNLEVVSNPRNASEYMVELNTPTFG------------ 185
            ..:|....|...:.|::|.:.|.||: .|.|:.    |..:|.......||.|
 Worm   171 DKNWDGSKFDLNEMLSNLVKLGATNLGLFQLDF----RILTEGKFVRIAPTLGSIVHNSTMISMI 231

  Fly   186 -----------EESQLPNSFIEILSV-LYIIKVPSSEIITLARK-MRTLEL--LLKTMINPIDTL 235
                       :..::...|.|..|: :.:.|..||..::::.. :|::..  |:..||:| ..:
 Worm   232 SEILEANGVQPDSEEISKEFEEYSSLQMKLAKYQSSGKLSISLPGVRSINFSSLITEMIHP-SRV 295

  Fly   236 NNRYISIRDFQMETGHNWQRFFEILIGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMT 300
            :..:..||....|  |  ..||:    |:....|..::.:    |:.|.|.:    .|:.:||.:
 Worm   296 SKIFGKIRVVTSE--H--PLFFK----SNETESLDTIIES----TSNKTLAN----FLIFNYIQS 344

  Fly   301 RFAIFLLDETMGGRESTECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLL 365
            .:.|      |.|.....|...|||....|:..::...|.:    ..|...:|.:.|:|:.. .|
 Worm   345 SYNI------MKGARRGNCEDDVRREFPRASLRVFMRNFVD----KGNRDGVKKLTEELKKN-TL 398

  Fly   366 QVDQNHLELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELD----YHQEH 426
            ::.|:...|.....:..::|.|||:: .:..|.     ||......|.:|...:||    |::..
 Worm   399 EMIQDTENLAPPVKESMLKKVEAIKV-TIGYPD-----HFDPPGTLDKEFENFDLDSTDSYYRIF 457

  Fly   427 LKVLQFRTQ---------------KMLAQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESEDVF 476
            .|:.:.|::               |.:.:.:..:...:|.||.   .||. ...|||.:...|..
 Worm   458 QKLNRLRSEQQMEFIAGETPISPIKEVLKVNANYKRSKNALTV---FAPF-LDDPFFDITYPDYV 518

  Fly   477 KYSLMGYIMAHHLISAFATEGITIGSDGNDQSFRSHRFEEAV------SCLSRNSEN-------- 527
            .....|:::||.:..:....|  :|.|.|.:.....|.|...      .||....:|
 Worm   519 NLFFSGFLIAHEIGHSVDANG--LGYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGK 581

  Fly   528 -------IDESMGDIAGLELAYFTYAKM--AKNRNRLDFTHLPPEQIFFLNVGQFFCGNSDMLVQ 583
                   |:|.:.|..|.|:.:..|.||  :|..:.:....:..:|::|......||
 Worm   582 KMNGTHSINEIIADWVGHEVTWRAYKKMDTSKMLSLIGLKDINMDQLYFRVQSLLFC-------- 638

  Fly   584 YKEDQVRLQRAIEGFEPFD--KAFGCY 608
            .:.|.:.|:..::...|.|  :..|.|
 Worm   639 RERDTISLEETLKDVYPTDNFRVNGAY 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	133/665 (20%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	131/662 (20%)