Protein Alignment Nepl8 and nep-22

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_509528.1
• Gene: nep-22 / 181144
• WormBaseID: WBGene00020788
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 785
• Identity: 137/785 - (17%)
• Similarity: 267/785 - (34%)
• Gaps: 238/785 - (30%)

  Fly    16 SNTRLLNGILSHVDKEANPCENYYNHAC-----------------GQYNMRHIDDTFFDIIQMLD 63
            |.|:..|.:|:.:|...:||:::|...|                 |.|:...:|
 Worm    67 SYTQAANYLLNGLDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVD----------- 120

  Fly    64 HQVNQNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCR---GAPRNMDSLSQYLKVISPGEGL 125
              |...:|..:.:::::|.    ..|..:......:.:|:   .:|.:..:: .|.::.|...|:
 Worm   121 --VYSEIVAALSKIDVTST----TTSKTERITKAAFETCKNNLASPADKTAV-VYAEITSLFGGV 178

  Fly   126 TWPQFIPDGSSWPQENFKWLKA--LAHLHRYG-LTNVFFNLEVVSNPRNA--------------- 172
              |.|   |.........|:.|  :...|..| ||....:.:...:.:||
 Worm   179 --PFF---GEPLKTNVDYWMVAGQIEQKHAVGTLTYTIASSDYKDHTKNALYTGPPGLSLARDFY 238

  Fly   173 --SEYMVELNTPTFGEESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTLELLLKTMINPIDTL 235
              .:|:.|:| ....:.:.|..:|......    .|.:..::..|:::...|:.:.....|.|.|
 Worm   239 VKPQYIAEVN-QRVSDVNDLLTAFANAAKK----NVGADALLAAAQEVVNFEVQIAMASWPDDLL 298

  Fly   236 NNRYISIRDFQMETGH------NWQRFFEILIGSSAAPELQ----VLVRNFRYFTALKELMD--K 288
            .|.......:.:.:..      ||:.:...|....|:...|    ::|....||..|..:.|  .
 Worm   299 RNYQQQYNPYNIASATTAYRAINWKSYLGQLFHGVASDADQANYNIVVTEPSYFAWLNSVFDGKT 363

  Fly   289 QDARLVASYIMTRFAIFLLDET-----------------------------MGGRE--------- 315
            .::.:||:|::   |..|.||:                             :|.||
 Worm   364 SNSTVVANYMI---AQLLADESDFINPATAKVSSDTNYIHYALRNGRGIKKIGKREYRMADLDGI 425

  Fly   316 STECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQ-NHLELTALQM 379
            |..|:..:...|......:|.:...|.:...|   ::||....:.:.|...:|. |.::
 Worm   426 SEGCMDLLTAYMPYGTGYVYVKSKSERNKVQA---DVKDQTTLIINNFQGMIDSLNWMD------ 481

  Fly   380 KFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELD-------YHQEHLKVLQFRTQK- 436
            .|...:|.         .|:|.|....|  :.:..|  |:.:       |:|::..::...|:.
 Worm   482 TFSKNRAH---------NKSDSLVKNFG--WPEAMF--GDFNDFTTVDAYNQDYASIIDLYTKDK 533

  Fly   437 -----MLAQSSKG-----------------------------HSEEQNILTYRSQAAPLPPPQPF 467
                 :.|...||                             :..|:|.:|: ..||..|   |:
 Worm   534 NDIYGIFAVLKKGMEVREFFRIMGEPADRTNFLQSPAMVNAWYQPERNSITF-PYAAWNP---PY 594

  Fly   468 FQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGN------------DQSFRSHRFEEA--- 517
            :.|.....:.::..|....|.|...:..||:..|.:|.            |.:..|...:.|
 Worm   595 YNLNYPQAYNFAGQGGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCV 659

  Fly   518 -----VSCLSRNSENI---------DESMGDIAGLELAYFTYAK-MAKNRNRLDFTHLP------ 561
                 ..|....:.||         .|::.|:.|.:.||.:|.: :|..|..::...||
 Worm   660 VTQFSTQCCPEKTGNIHCANGATTQGENIADLGGQQAAYRSYRQYVATTRKGVEEDRLPGLENYT 724

  Fly   562 PEQIFFLNVGQFFC---GNSDMLVQ-----YKEDQVRLQRAIEGFEPFDKAFGCYRNKPKHE--- 615
            |.|||::..|..:|   .:::::.|     :...|.|..:.::....|.|.|||.|..|.:.
 Worm   725 PNQIFWITYGYSWCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEPS 789

  Fly   616 -KCRL 619
             :|::
 Worm   790 GRCKV 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	131/766 (17%)
nep-22	NP_509528.1	M13	83..793	CDD:341056	131/766 (17%)