DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl8 and nep-22

DIOPT Version :9

Sequence 1:	NP_609795.2	Gene:	Nepl8 / 34983	FlyBaseID:	FBgn0032585	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_509528.1	Gene:	nep-22 / 181144	WormBaseID:	WBGene00020788	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	785	Identity:	137/785 - (17%)
Similarity:	267/785 - (34%)	Gaps:	238/785 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SNTRLLNGILSHVDKEANPCENYYNHAC-----------------GQYNMRHIDDTFFDIIQMLD 63
            |.|:..|.:|:.:|...:||:::|...|                 |.|:...:|
Worm    67 SYTQAANYLLNGLDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVD----------- 120

  Fly    64 HQVNQNLVKLMDELEMSSQLPDFNVSSVDGKVLRYYLSCR---GAPRNMDSLSQYLKVISPGEGL 125
              |...:|..:.:::::|.    ..|..:......:.:|:   .:|.:..:: .|.::.|...|:
Worm   121 --VYSEIVAALSKIDVTST----TTSKTERITKAAFETCKNNLASPADKTAV-VYAEITSLFGGV 178

  Fly   126 TWPQFIPDGSSWPQENFKWLKA--LAHLHRYG-LTNVFFNLEVVSNPRNA--------------- 172
              |.|   |.........|:.|  :...|..| ||....:.:...:.:||
Worm   179 --PFF---GEPLKTNVDYWMVAGQIEQKHAVGTLTYTIASSDYKDHTKNALYTGPPGLSLARDFY 238

  Fly   173 --SEYMVELNTPTFGEESQLPNSFIEILSVLYIIKVPSSEIITLARKMRTLELLLKTMINPIDTL 235
              .:|:.|:| ....:.:.|..:|......    .|.:..::..|:::...|:.:.....|.|.|
Worm   239 VKPQYIAEVN-QRVSDVNDLLTAFANAAKK----NVGADALLAAAQEVVNFEVQIAMASWPDDLL 298

  Fly   236 NNRYISIRDFQMETGH------NWQRFFEILIGSSAAPELQ----VLVRNFRYFTALKELMD--K 288
            .|.......:.:.:..      ||:.:...|....|:...|    ::|....||..|..:.|  .
Worm   299 RNYQQQYNPYNIASATTAYRAINWKSYLGQLFHGVASDADQANYNIVVTEPSYFAWLNSVFDGKT 363

  Fly   289 QDARLVASYIMTRFAIFLLDET-----------------------------MGGRE--------- 315
            .::.:||:|::   |..|.||:                             :|.||
Worm   364 SNSTVVANYMI---AQLLADESDFINPATAKVSSDTNYIHYALRNGRGIKKIGKREYRMADLDGI 425

  Fly   316 STECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQ-NHLELTALQM 379
            |..|:..:...|......:|.:...|.:...|   ::||....:.:.|...:|. |.::
Worm   426 SEGCMDLLTAYMPYGTGYVYVKSKSERNKVQA---DVKDQTTLIINNFQGMIDSLNWMD------ 481

  Fly   380 KFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELD-------YHQEHLKVLQFRTQK- 436
            .|...:|.         .|:|.|....|  :.:..|  |:.:       |:|::..::...|:.
Worm   482 TFSKNRAH---------NKSDSLVKNFG--WPEAMF--GDFNDFTTVDAYNQDYASIIDLYTKDK 533

  Fly   437 -----MLAQSSKG-----------------------------HSEEQNILTYRSQAAPLPPPQPF 467
                 :.|...||                             :..|:|.:|: ..||..|   |:
Worm   534 NDIYGIFAVLKKGMEVREFFRIMGEPADRTNFLQSPAMVNAWYQPERNSITF-PYAAWNP---PY 594

  Fly   468 FQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSDGN------------DQSFRSHRFEEA--- 517
            :.|.....:.::..|....|.|...:..||:..|.:|.            |.:..|...:.|
Worm   595 YNLNYPQAYNFAGQGGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCV 659

  Fly   518 -----VSCLSRNSENI---------DESMGDIAGLELAYFTYAK-MAKNRNRLDFTHLP------ 561
                 ..|....:.||         .|::.|:.|.:.||.:|.: :|..|..::...||
Worm   660 VTQFSTQCCPEKTGNIHCANGATTQGENIADLGGQQAAYRSYRQYVATTRKGVEEDRLPGLENYT 724

  Fly   562 PEQIFFLNVGQFFC---GNSDMLVQ-----YKEDQVRLQRAIEGFEPFDKAFGCYRNKPKHE--- 615
            |.|||::..|..:|   .:::::.|     :...|.|..:.::....|.|.|||.|..|.:.
Worm   725 PNQIFWITYGYSWCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEPS 789

  Fly   616 -KCRL 619
             :|::
Worm   790 GRCKV 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	131/766 (17%)
nep-22	NP_509528.1	PepO	76..795	CDD:226118	134/776 (17%)
nep-22	NP_509528.1	M13	83..793	CDD:189000	131/766 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910