Protein Alignment Nepl8 and nep-21

DIOPT Version :10

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001360525.1
• Gene: nep-21 / 179925
• WormBaseID: WBGene00011794
• Length: 864
• Species: Caenorhabditis elegans
• Alignment Length: 740
• Identity: 147/740 - (19%)
• Similarity: 258/740 - (34%)
• Gaps: 195/740 - (26%)

  Fly    19 RLLNGILSHVDKEANPCENYYNHACGQYN----------MRHIDDTFFDIIQMLDHQVNQNLVKL 73
            ||...:..:::.:.||||::|..|||.|.          :||   |..|:...|:.||...|
 Worm   180 RLAGFLAENLNSKINPCEDFYEFACGNYGLNKNLPANKPLRH---TISDVQSRLNKQVKSML--- 238

  Fly    74 MDELEMSSQLP-DFNVSSVDGKVLRYYLSCRGAPRNMDSLSQYLKVISPGEGLTWPQFIPDGSSW 137
                    |.| ..|....|.....||..|........:..:.::.|:...| .||..  :|..|
 Worm   239 --------QSPISANEKPWDKVAKGYYQKCLDEEELESTGVEAMRDIAKRIG-GWPTL--EGDKW 292

  Fly   138 PQENFKWLKALA-HLHRYGLTNVFFNLEVVSNPRNASEYMVELNTPTFGEESQLP---------- 191
            .:.:..|.:.:| .|:..|:..|...:.|..:|.|:|..::||:.|.:|..|:.|
 Worm   293 QEWSHSWEEQIALVLNLTGVNAVILEMAVTHDPSNSSRSVIELDQPKWGAGSRYPYLSGANDPML 357

  Fly   192 NSFIEILSVLYIIKVPSSEIITLARKMRTLELLLKTMINPIDTLNNRYISIRDFQMETGHN---- 252
            .::..::. :..:.:.:...|........:|..||.:....|.:..|       ..|.|:|
 Worm   358 RNYTTLMK-MTAVALGADPAIAEKEMNEAMEFELKLVNFSADDMVRR-------DPERGNNRFEL 414

  Fly   253 WQ---------------RFFEILIGSSAAPELQVLVRNFRYFTALKELMDKQDARLVASYIMTR- 301
            ||               ..|:.|:..|  |...|:||...||..::.::.....|::|:||..|
 Worm   415 WQLKSVFPFINFEKYLKTVFKELVALS--PNHTVIVREIDYFVGIQHVLQSTPKRVLANYISWRL 477

  Fly   302 -----------FAIFLLDETMGGRES--------------------TECVSQVRRNMNLAANMLY 335
                       |:.||   ....||.                    .:||:.....|::....|:
 Worm   478 VQGGPTGDYFSFSPFL---PPSAREPFYQFKANQTGMFNSPPPDRWEDCVTLSVIMMDMPVGRLF 539

  Fly   336 KERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHL-----ELTALQMKFFVRKAEAIEI---- 391
            .|.|||.......:.|:...   |:::|:.|:   |:     |:|..:.   :.||..||.
 Worm   540 VENFFEKERAMKKMTELTSY---LKNEFIKQL---HVLDWMDEITRRRA---ISKANMIEYKSGF 595

  Fly   392 --------------NVVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKML---- 438
                          .::..|:         :|...|......:.:.:|.|::.|...:.|.
 Worm   596 PMVLFNDTWMEKNWGMIIKPR---------EYLLHLTIRVKLVRFTEELLRLDQPLDRSMWFQSP 651

  Fly   439 AQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESEDVFKYSLMGYIMAHHLISAFATEGITIGSD 503
            ||....::...|.:.:.:.....    ||..|...:...|.::|.::.|.:..||..:|......
 Worm   652 AQVDAYYAPNNNEMIFPAGIMQF----PFLTLGVPNYITYGMVGAVIGHEVSHAFDDQGGQYDEM 712

  Fly   504 GNDQSF----RSHRFEEAVSCLSRNSENI---------------DESMGDIAGLELAYFTYAKMA 549
            ||...:    ...:|.|...|..|..||:               .|::.|..|::.|:..|....
 Worm   713 GNLNDWWDAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWK 777

  Fly   550 KNRNRLD------FTHLPPEQIFFLNVGQFFCGNSDMLVQYKE------------DQVRLQRAIE 596
            .|...:.      |.:...:|:|||.....:|.    ||:.|.            .:.|....::
 Worm   778 SNTTGISEPALPGFQNFTSQQMFFLAYANNWCS----LVRPKHYIQIILTDVHAPSKYRAMIPLQ 838

  Fly   597 GFEPFDKAFGCYRNKPKH--EKCRL 619
            ....|.|||.|....|.:  .||::
 Worm   839 NRPEFAKAFQCPIGSPMNPERKCQV 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:472708	144/724 (20%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	144/724 (20%)