Protein Alignment Nepl8 and nep-23

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_503004.2
• Gene: nep-23 / 178472
• WormBaseID: WBGene00013785
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 702
• Identity: 136/702 - (19%)
• Similarity: 250/702 - (35%)
• Gaps: 178/702 - (25%)

  Fly    20 LLNGILSHVDKEANPCENYYNHACGQYNMRHIDDTFFDIIQMLDHQVNQNLVKLMDELEMSSQLP 84
            |.:.:.::.|..|:||:|:|...||:.:...:....     ...|.:.:||::  :.:......|
 Worm    84 LAHQLHNYHDPSADPCDNFYQSVCGKQHEHSLKSGL-----AKKHLILRNLIR--ETITNRKVTP 141

  Fly    85 DFNVSSVDGKVLRYYLSC---RGAPRNMDSLSQYLK-----VISPGEGLTWPQFIPDGS-SWPQE 140
               .|..:.::.:::..|   :.|..:.|...|.|:     |.|.|   :||.    || :|.:.
 Worm   142 ---TSKSENEMRKFHGICSKYQRANSSSDIAQQALRDIFRDVQSIG---SWPA----GSRNWNES 196

  Fly   141 NFKWLKALAHL-----HRYGLTNVFFNLE---VVSNPRNASEYMVELNTPTFGEESQLPNSFIEI 197
            :|...:.|.:|     ..:||..:.|...   ::|...:...|            |:|..:.:.|
 Worm   197 DFNLNEMLNNLVKLGQRNFGLFQISFKYRDQLLISAEEHRRNY------------SKLEPTILNI 249

  Fly   198 LSVLYIIKVPSSEIITLARKMR---TLELLLKTMINPIDTLNNRYISIRDFQMETGHNWQRFFEI 259
            .....::    .:.|.|.:.:.   :||.|||.... :|.::....::.|..:.:..     |..
 Worm   250 FETNGLV----PDRIQLLKDLEGFASLEALLKNHYY-LDNMDKMKPAVLDDLVPSVD-----FMG 304

  Fly   260 LIGSSAAP---------ELQVLVRNFRYFT----ALKELMDKQDARLVASYIMTRFAIFLLD--- 308
            |:.:..:|         ||:..|.|...|.    .|:.::.....|.:|:|::..|....||
 Worm   305 LVKAMISPGKEHLMPKIELKTSVLNQTLFNDENMNLEAIILDTPKRTLANYLIFNFIDSSLDHLV 369

  Fly   309 -ETMGGRESTECVSQVRRNMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHL 372
             ||...:.:| |..:|...:..|:..::...:.:.        |.:|:..:|       .::..:
 Worm   370 FETTSQKGNT-CEDKVITYLPRASLRVFIRNYVDK--------ENRDLITQL-------AEKTRI 418

  Fly   373 ELTALQMKFFVRKAEAIEINVVNLPKTDDLRHFIGQYYQDLQFPTGELDYHQEHLKVLQFRTQKM 437
            .|..|.......|||:.::   .|.|.:.:...||  |.|...|.|.||...::|.:....|...
 Worm   419 ALHTLVQNSTWLKAESKQL---ALDKINAMGKMIG--YPDFFEPPGTLDGMFKNLNLDSSDTYYT 478

  Fly   438 LAQSSKGHSEEQNILTYRSQAAPLPP-------------------------PQPFFQLESEDVFK 477
            .....:.:..||. :.|.::..||.|                         ..|.|.....|...
 Worm   479 ALNKLERYFVEQK-MDYFAEETPLDPDLRVFEMNAYYYIPGNQLNFLAPFFDDPMFDSTYPDYVN 542

  Fly   478 YSLMGYIMAHHLISAFATEGITIGSDGNDQSFRSH---RFEEAVSCLSR---------------N 524
            .::.|.|:.|.:..||....|.....|.:...:..   .:|....||:.               .
 Worm   543 IAMSGNIIGHEMGHAFGPHAILRTVRGREVWMKPEELAEYESRAQCLANQYSEYDDPDFGRVFDG 607

  Fly   525 SENIDESMGDIAGLELAYFTYAKMAK-----NRNR-LDFTHLPPEQIFFLNVGQFFCGNSDMLVQ 583
            .:.|||.:.|..|.|:::    ||.|     |..| :.|.....:|::| .||        .|..
 Worm   608 GKVIDELVADNIGREVSW----KMFKSLDLTNATRIIGFEDYDIDQLYF-RVG--------ALTH 659

  Fly   584 YKEDQVR-LQRAIEGFEP---------------FDKAFGCYRNKPKH--EKC 617
            .....:| |:.:||...|               |.:||.|....|.:  :||
 Worm   660 CTPHAMRDLKGSIESSHPRKAFRVNGVYANLPEFARAFNCPTGSPMNPRKKC 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	134/690 (19%)
nep-23	NP_503004.2	M13	96..711	CDD:189000	132/688 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910