Protein Alignment Nepl8 and nep-16

DIOPT Version :9

• Sequence 1: NP_609795.2
• Gene: Nepl8 / 34983
• FlyBaseID: FBgn0032585
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001023203.2
• Gene: nep-16 / 177541
• WormBaseID: WBGene00018472
• Length: 868
• Species: Caenorhabditis elegans
• Alignment Length: 714
• Identity: 140/714 - (19%)
• Similarity: 266/714 - (37%)
• Gaps: 211/714 - (29%)

  Fly     1 MWIICLLLVPLVAASS----NTR----LLNGILSHVDKEANPCENYYNHACGQYNMRHIDDTFFD 57
            :|:|.......:.|.|    |||    :...:.|.:|.|..||||:|.::|.:|:.:..|.....
 Worm   215 VWVITTDGFRTIGAKSTNVCNTRQCIDIAFRLSSCIDDEIEPCENFYRYSCQRYHSQTADKQMSF 279

  Fly    58 IIQMLDHQVNQNLVKLMDELEMSSQLPDFNVSSVDGKVLR-YYLSCRGAPRNMDSLSQYLKVISP 121
            :.|:.|..: :.:..|:...|.|..||.      ..::.| .|.:|..|.....:        :|
 Worm   280 LSQLKDESL-RRMHSLLSSEEDSRLLPK------SARLSRSLYSACMNAVLRSSN--------AP 329

  Fly   122 GEGLTWPQFIP------DGSSWPQENFKWLKALAHLH----RYGLTNVFFNLEVVSNPRNASEYM 176
            .:.||:.:..|      |..::..:::.|.:....|.    ||.|  :.::.:|  :|::.|:.:
 Worm   330 TDLLTFIRNFPCGPLLRDCQNFHADSYSWERHAGMLDWYAGRYNL--IVYDRDV--HPQDRSKII 390

  Fly   177 VELN----TPTFG--EESQL------PNSFIEILSVLY------------IIKVP---SSEIITL 214
            :::.    ||..|  |...:      |..|..:|.:..            :::.|   .|::..:
 Worm   391 LQIKPPDLTPIVGLIERDLIDLARPSPTEFEPLLQLSLRQNLLSAFARDSLLRDPRDVQSQLDEV 455

  Fly   215 ARKMRTLELLLKTMINPIDTLNNRYISI------------RDF---QMETGHNWQRFFEILIGSS 264
            ||.|  ::|.:....:...|.|..|::|            |:|   |:...:.|
 Worm   456 ARLM--VDLYISARQSASLTPNTTYMTIGEMFQALPQLYLREFLDAQLSNTYRW----------- 507

  Fly   265 AAPELQVL-VRNFRYFTALKELMDKQDARLVASYIMTRFAIFLLDETMGGRES---TECVSQVRR 325
              .|..:| ::::.||..|.::|.:...:.||:|::|.....|...:...|:.   .|||.|:
 Worm   508 --TETDMLSIQDYDYFARLSDIMAQTSRQAVANYLLTVTVWNLKQYSYSPRDQYGWRECVDQI-- 568

  Fly   326 NMNLAANMLYKERFFEDSTFSANILEIKDIFEKLRHQFLLQVDQNHLELTALQ-------MKFFV 383
                ::..:.::.:.:.::.:.::.:|::..:.|:..| |.|.::    |.||       :.|:|
 Worm   569 ----SSFEIGRKMYVDKASQTIDLPKIQEFLQNLKIDF-LSVHRS----TPLQYLSNINRLGFYV 624

  Fly   384 ---RKAEAIE-----INVVNLPKTDDLRHFIGQYYQDLQFPTG--ELDYHQEHL---------KV 429
               |:.:..|     ::.|:|.:||         |.|.....|  |.||....:         ..
 Worm   625 GFPRRLQNEELIWKPVSQVSLNETD---------YFDSMIRVGKAERDYTMSQIGTYLDNDDTTT 680

  Fly   430 LQFRTQKMLAQSSKGHSEEQNILTYRSQAAPLPPPQPFFQLESEDVFK---YSLMGYIMAHHLIS 491
            .......||..|:.|           :...||...:|...|..::|..   ||.:| |....:||
 Worm   681 FPISDPTMLYNSNVG-----------AIVIPLAFIEPPIYLPGDEVPMYGIYSSLG-ITTLQMIS 733

  Fly   492 AFATEGI--TIGSDGNDQSFRSHRFEEAVSCLSRNSENIDESMGDIAGLEL------AYFTYAKM 548
            ....:|:  |...:..|..||..     :....:.|.||:..:  :|.:||      |.::|||.
 Worm   734 KVFWQGLDKTSQLECLDNVFRGF-----LDANRQRSPNIEPEL--LATIELADAFKSALYSYAKW 791

  Fly   549 AKNRNRLDFTHLPPEQI------------FFLNVGQFFCGNSDMLVQYKEDQVRLQRAIEGFEP 600
            ..:.      |:..|:.            ..|.....||..                  ||.||
 Worm   792 QNDH------HIHHEKTLPAFDSTDSMRSLMLTFSTMFCSG------------------EGSEP 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl8	NP_609795.2	GluZincin	32..618	CDD:301352	130/675 (19%)
nep-16	NP_001023203.2	GluZincin	254..>725	CDD:387391	102/535 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010